1999
Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment
Elsworth J, Taylor J, Sladek J, Collier T, Redmond D, Roth R. Striatal dopaminergic correlates of stable parkinsonism and degree of recovery in old-world primates one year after MPTP treatment. Neuroscience 1999, 95: 399-408. PMID: 10658619, DOI: 10.1016/s0306-4522(99)00437-6.Peer-Reviewed Original ResearchConceptsHomovanillic acid/dopamine ratioMPTP treatmentStriatal dopamine levelsDopamine levelsDopamine lossDopamine depletionDopamine ratioStriatal subregionsNucleus accumbensCaudate nucleusDopamine concentrationsOne-yearSeverity categoriesDopamine neuron integrityVentromedial caudate nucleusStriatal dopamine lossHomovanillic acid concentrationsStriatal dopaminergic functionMarked increaseNormal motor performancePaucity of dataMetabolic activityNon-human primatesParkinsonian disabilityTetrahydropyridine (MPTP) modelSpontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys
Taylor J, Elsworth J, Lawrence M, Sladek J, Roth R, Redmond D. Spontaneous Blink Rates Correlate with Dopamine Levels in the Caudate Nucleus of MPTP-Treated Monkeys. Experimental Neurology 1999, 158: 214-220. PMID: 10448434, DOI: 10.1006/exnr.1999.7093.Peer-Reviewed Original ResearchConceptsCaudate nucleusConcentration of DAEye blink rateBlink rateDA ratioDopaminergic regulationD1 agonist dihydrexidineDA D2 receptorsDopaminergic neurotoxin MPTPSeverity of parkinsonismSpontaneous eye blink rateSpecific brain regionsAntiparkinsonian effectsDA depletionD2 agonistDopamine D1Dopamine levelsNeurotoxin MPTPD2 receptorsMPTPNormal animalsRostral portionSubcortical regionsBrain regionsVentromedial region
1998
Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts From Multiple Donors Do Not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. DOI: 10.1016/s0963-6897(98)00007-4.Peer-Reviewed Original ResearchConceptsDopamine neuronsDouble graftsAdult African green monkeysVentral mesencephalic dopamine neuronsMultiple donorsGrafts of tissueMore dopamine neuronsSymptoms of parkinsonismMesencephalic dopamine neuronsDopamine cell survivalHuman clinical trialsAfrican green monkeysIntrastriatal graftsPositive neuronsTotal numberClinical trialsDopamine levelsCaudate nucleusRecipient animalsGraftGrafted tissueNeuronsGreen monkeysNonhuman primatesDorsoventral extentIntrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Intrastriatal Grafts from Multiple Donors do not Result in a Proportional Increase in Survival of Dopamine Neurons in Nonhuman Primates. Cell Transplantation 1998, 7: 87-96. PMID: 9588591, DOI: 10.1177/096368979800700204.Peer-Reviewed Original ResearchConceptsDopamine neuronsDouble graftsAdult African green monkeysVentral mesencephalic dopamine neuronsMultiple donorsGrafts of tissueMore dopamine neuronsSymptoms of parkinsonismMesencephalic dopamine neuronsDopamine cell survivalHuman clinical trialsAfrican green monkeysIntrastriatal graftsPositive neuronsTotal numberClinical trialsDopamine levelsCaudate nucleusRecipient animalsGraftGrafted tissueNeuronsGreen monkeysNonhuman primatesDorsoventral extent
1996
Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys
Elsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.Peer-Reviewed Original ResearchConceptsFetal ventral mesencephalonVentral mesencephalonCaudate nucleusGraft siteDopamine neuronsDopamine concentrationsBehavioral recoveryTyrosine hydroxylase-positive neuronsHomovanillic acid/dopamine ratioFetal dopamine neuronsGrafted dopamine neuronsIntrastriatal transplantsParkinsonian primatesGrafted neuronsIntrastriatal transplantationGestational ageTransplant proceduresDopamine ratioDopamine productionSignificant elevationNucleus accumbensDopamine systemSham graftsGraftBrain regionsRestoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of dopamine transporter density in the striatum of fetal ventral mesencephalon-grafted, but not sham-grafted, MPTP-treated parkinsonian monkeys. Cell Transplantation 1996, 5: 315-325. DOI: 10.1016/0963-6897(95)02034-9.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatumRestoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys
Elsworth J, Brittan M, Taylor J, Sladek J, Al-Tikriti M, Zea-Ponce Y, Innis R, Redmond D, Roth R. Restoration of Dopamine Transporter Density in the Striatum of Fetal Ventral Mesencephalon-Grafted, but not Sham-Grafted, Mptp-Treated Parkinsonian Monkeys. Cell Transplantation 1996, 5: 315-325. PMID: 8689042, DOI: 10.1177/096368979600500220.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineDopamineDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationHomovanillic AcidIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMesencephalonNeostriatumNerve Tissue ProteinsParkinson Disease, SecondaryProtein BindingPutamenConceptsFetal dopamine neuronsDopamine transporter densityDopamine neuronsParkinsonian monkeysBehavioral recoveryTransporter densityCaudate nucleusNeural graftingDopamine systemImplantation procedureDopamine concentrationsFull behavioral recoveryPutamen of MPTPStriatal dopamine deficiencyStriatal dopamine concentrationsDopamine-depleted striatumStriatum of MPTPDopamine depletionVentral mesencephalonDopamine deficiencyMotor abnormalitiesDopaminergic innervationUseful treatmentStriatal nucleiAdult striatum
1994
Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems
Collier T, Elsworth J, Taylor J, Sladek J, Roth R, Redmond D. Peripheral nerve-dopamine neuron co-grafts in mptp-treated monkeys: Augmentation of tyrosine hydroxylase-positive fiber staining and dopamine content in host systems. Neuroscience 1994, 61: 875-889. PMID: 7838385, DOI: 10.1016/0306-4522(94)90410-3.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusNon-human primatesLateral ventricleSeptal areaDopamine systemEmbryonic ventral mesencephalic tissueTyrosine hydroxylase-positive fibersHomovanillic acid/dopamine ratioDopamine neuron graftsDopamine-depleted monkeysEmbryonic ventral mesencephalonGrafted dopamine neuronsVentral mesencephalic tissueLateral septal areaLevels of dopamineMesencephalic dopamine neuronsMetabolite homovanillic acidBrain dopamine systemsMPTP-treated monkeysDirection of normalizationAfrican green monkeysInjury-induced regenerationMesencephalic tissueSaphenous nerveNovel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function
Elsworth J, Al-Tikriti M, Sladek J, Taylor J, Innis R, Redmond D, Roth R. Novel Radioligands for the Dopamine Transporter Demonstrate the Presence of Intrastriatal Nigral Grafts in the MPTP-Treated Monkey: Correlation with Improved Behavioral Function. Experimental Neurology 1994, 126: 299-304. PMID: 7925828, DOI: 10.1006/exnr.1994.1068.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsAutoradiographyBrain Tissue TransplantationCarrier ProteinsChlorocebus aethiopsCocaineCorpus StriatumDopamine Plasma Membrane Transport ProteinsFetal Tissue TransplantationIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsParkinson Disease, SecondaryRadioligand AssaySerotonin Plasma Membrane Transport ProteinsSubstantia NigraTransplantation, HeterotopicTransplantation, HomologousConceptsCaudate nucleusFetal ventral mesencephalic cellsIntrastriatal nigral graftsVentral mesencephalic cellsAdult MPTPNigral graftsSerotonergic fibersTransplantation procedureMesencephalic cellsNovel radioligandNeurochemical identityDopamine transporterTransporter sitesSerotonin transporterBehavioral functionsMPTPCocaine analogMonkeysCocaine derivativePreliminary studyHigh affinityDopaminergicGraft
1993
Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates
Sladek J, Elsworth J, Roth R, Evans L, Collier T, Cooper S, Taylor J, Redmond D. Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates. Experimental Neurology 1993, 122: 16-27. PMID: 8101820, DOI: 10.1006/exnr.1993.1103.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusMesencephalic dopamine cell groupsTyrosine hydroxylase-positive neuronsTissue dopamine levelsUnfixed brain slicesDopamine cell groupsCell survivalDopamine cell survivalDopamine cell numberDays of gestationEarly gestation tissuesTime of implantationAfrican green monkeysVideo-based imagingGraft survivalMesencephalic tissueDonor graftsGestational ageNeural graftsNeurological disabilityDopaminergic neuronsGraft sizeDopamine contentSingle graft
1991
Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls
Taylor J, Elsworth J, Roth R, Sladek J, Collier T, Redmond D. Grafting of fetal substantia nigra to striatum reverses behavioral deficits induced by MPTP in primates: a comparison with other types of grafts as controls. Experimental Brain Research 1991, 85: 335-348. PMID: 1893983, DOI: 10.1007/bf00229411.Peer-Reviewed Original ResearchConceptsCaudate nucleusBehavioral deficitsHealthy behaviorsFetal substantia nigra cellsFetal substantia nigraIdiopathic Parkinson's diseasePoverty of movementType of graftDays/weekSubstantia nigra cellsTime of sacrificePre-treatment levelsSN cellsSpecific behavioral effectsMPTP treatmentMPTP toxicityParkinsonian signsSubstantia nigraControl subjectsInitiation of movementBrain sitesLimb tremorParkinson's diseaseControl animalsMPTP
1990
Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys
Taylor J, Elsworth J, Roth R, Collier T, Sladek J, Redmond D. Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. Progress In Brain Research 1990, 82: 543-559. PMID: 2290957, DOI: 10.1016/s0079-6123(08)62645-x.Peer-Reviewed Original ResearchConceptsCSF HVA levelsHVA levelsBehavioral recoveryCaudate nucleusSN graftsDopamine neuronsDopamine productionHVA/dopamine ratioCentral dopamine productionFetal substantia nigraStriatum of subjectsSubstantia nigra transplantsRelease of dopamineImproved parkinsonismHost striatumHost brainFetal graftsMPTP administrationParkinsonian signsTH immunohistochemistrySubstantia nigraDopamine ratioSmall graftsBehavioral deficitsGraft
1989
Symptomatic and asymptomatic 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated primates: Biochemical changes in striatal regions
Elsworth J, Deutch A, Redmond D, Taylor J, Sladek J, Roth R. Symptomatic and asymptomatic 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated primates: Biochemical changes in striatal regions. Neuroscience 1989, 33: 323-331. PMID: 2622529, DOI: 10.1016/0306-4522(89)90212-1.Peer-Reviewed Original ResearchConceptsHomovanillic acid concentrationsParkinson's diseaseStriatal regionsHomovanillic acid/dopamine ratioGross motor abnormalitiesDepletion of dopamineHomovanillic acid levelsLoss of dopamineIdiopathic Parkinson's diseaseCaudate nucleus dopamineAsymptomatic monkeysTetrahydropyridine (MPTP) treatmentAsymptomatic groupSymptomatic groupDopamine lossTetrahydropyridine (MPTP) toxicityMotor abnormalitiesDopamine ratioCaudate nucleusSignificant negative correlationVentromedial regionStriatum