Featured Publications
MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling
Huang G, Thompson SL, Taylor JR. MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling. Alcohol Clinical And Experimental Research 2021, 45: 732-742. PMID: 33587295, PMCID: PMC8076072, DOI: 10.1111/acer.14576.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinge DrinkingDose-Response Relationship, DrugDrug Evaluation, PreclinicalExcitatory Amino Acid AntagonistsFemaleHomer Scaffolding ProteinsMaleMAP Kinase Signaling SystemMice, Inbred C57BLMitogen-Activated Protein Kinase 1Nucleus AccumbensPyridinesReceptor, Metabotropic Glutamate 5Septal NucleiSex CharacteristicsConceptsEffects of MPEPFemale C57BL/6 miceAlcohol intakeAlcohol consumptionNegative allosteric modulatorsLocomotor activityC57BL/6 miceFemale miceMale miceHomer2 expressionBinge drinkingMetabotropic glutamate receptor 5MGlu5 negative allosteric modulatorsSex differencesBinge alcohol consumptionGlutamate receptor 5Dose-response effectExcessive alcohol useERK2 expressionDose-response relationshipPotential sex differencesERK2 signalingBed nucleusNucleus accumbensStria terminalis
2022
Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents
Sequeira M, Taylor J, Gourley S. Utility and Implementation of Oral Corticosteroid Exposure in Behavioral Neuroscience Research with Rodents. Neuromethods 2022, 190: 223-231. DOI: 10.1007/978-1-0716-2748-8_12.Peer-Reviewed Original ResearchChronic antidepressant treatmentChronic CORT exposureDepression-like phenomenaHelplessness-like behaviorOral corticosteroid exposureDepressive-like stateNeurobiology of depressionChronic mild stressCohort of animalsMultiple biological factorsCorticosteroid exposureAntidepressant actionAntidepressant treatmentAdrenal hormonesC57BL/6 miceCORT exposureResilient miceNaïve rodentsMild stressExposure resultsMiceExposure procedureCorticosteroneExposure periodDepression