Clinical Research Projects

This project is aimed to investigate reproductive outcomes including ovarian function, hormonal recovery, oocyte collection, embryo generation, pregnancy and livebirth rates in patients (children and reproductive aged women up to 51 years of age) who underwent fertility preservation treatments (i.e. oocyte, embryo freezing, ovarian tissue freezing and transplantation). The research plan is to analyze the demographics and indications for fertility preservation treatments, review the techniques provided to different patient subgroups in order to identify discrepancies or trends among them, and to study the reproductive outcomes achieved. Main outcomes measures were pregnancy and live birth rates.

The primary aim of this project is to both retrospectively and prospectively analyze the outcomes of ovarian tissue cryopreservation and transplantation. In addition, a small tissue sample will be utilized for laboratory research investigating the molecular aspects of chemotherapy-induced ovarian aging (R01 grant - 21-004650).

This prospective longitudinal study is aimed to determine if the ovarian reserve declines more significantly in response to gonadotoxic chemotherapy or with age in women carrying ATM-Pathway mutations such as BRCA1, BRCA2, ATM, BARD1, CHEK2, NBN, PALB2, RAD51C, RAD51D, TP53 and others. compared to those without the mutations.