Within tarantula venom, new hope for safe and novel painkillers found
Screening more than 100 spider toxins, Yale researchers identified a protein from the venom of the Peruvian green velvet tarantula that blunts activity in pain-transmitting neurons. The findings, reported in the March 3 issue of the journal Current Biology, show the new screening method used by the scientists has the potential to search millions of different spider toxins for safe pain-killing drugs and therapies.
Our recent TRPA1 toxineering paper, led by Junhong Gui, has been covered by the New York Times.
"Toxineering," a new method developed by investigators at the Kavli Institute for Neuroscience at Yale, may be used to screen millions of spider toxins for safe pain-killing drugs and therapies. With it, Michael Nitabach and his colleagues have identified a protein from the venom of the Peruvian green velvet tarantula that targets an ion channel linked to neuropathic pain.Source: The New York Times
Lighting a new path to understanding the 'language' of the brain
School of Medicine researchers have developed a new technique that allows them to non-invasively and simultaneously measure electrical activity in many neurons in a living organism, a prerequisite for understanding the complex language of the brain. The technique, described in the Aug. 8 issue of the journal Cell, involves inserting a fluorescent protein that varies in intensity in response to changes in electrical signals into neurons and recording the changing light with optical sensors.
$20M Federal Grant Renewed for Yale Tobacco Center of Regulatory Science
The National Institutes of Health (NIH) and the U.S. Food and Drug Administration (FDA) have renewed a $20 million grant for the Yale Tobacco Center of Regulatory Science (TCORS). The Yale center is led by co-directors Suchitra Krishnan-Sarin, PhD, Albert E. Kent Professor of Psychiatry; and Stephanie O’Malley, PhD, Elizabeth Mears and House Jameson Professor of Psychiatry.
What Is Psilocybin Therapy? A Detailed Scientific Guide to This Psychedelic Approach for Mental Health
Christopher Pittenger, MD, PhD, Elizabeth Mears and House Jameson Professor of Psychiatry, spoke to Everyday Health about clinical treatments involving psilocybin therapy.Source: Everyday Health
D'Souza, Gelernter Awarded Grant to Study Genetic Risk Factors in Cannabis Use Disorder
Deepak Cyril D’Souza, MD, and Joel Gelernter, MD, will study the biology of a person’s response to tetrahydrocannabinol (THC), the active constituent of cannabis. They will identify genetic risk factors to cannabis use disorder and study how cannabis risk variants influence THC response in a laboratory setting.
In Study of Veterans, Positive Personality Traits Moderate Persistent High Alcohol Consumption
Peter Na, MD, MPH, assistant professor of psychiatry, and Robert Pietrzak, PhD, MPH, professor of psychiatry and of public health, led a research team that examined the psychosocial moderators of high alcohol consumption determined by polygenic risk in military veterans.Source: Psychological Medicine
A Single Dose of Psilocybin Boosts Neuroplasticity and Reduces Depression Symptoms
Patrick Skosnik, PhD, associate professor of psychiatry, and Deepak D'Souza, MD, Albert E Kent Professor of Psychiatry, are first and senior authors, respectively, of a paper in Journal of Psychopharmacology that provides evidence that psilocybin induces lasting changes in neuroplasticity and that these changes are linked to improvements in depression symptoms.Source: PsyPost
Huckins to Receive 2023 International Society of Psychiatric Genetics Theodore Reich Early Career Award
Laura Huckins, PhD, associate professor of psychiatry, has been awarded the 2023 International Society of Psychiatric Genetics (ISPG) Theodore Reich Early Career Award. Huckins was selected for the award based on her published work describing the genetic underpinnings of eating disorders and PTSD as well as for her service to the psychiatric genetics community.
Investigators Launch Study Aimed at Accelerating Understanding of Bipolar Disorder
A multidisciplinary team of researchers based at Yale will launch a series of studies aimed at accelerating understanding of bipolar disorder and generating new and more effective treatments. Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience and Professor of Psychiatry, and in the Child Study Center and of Radiology and Biomedical Imaging, will lead the research team.
Girgenti Paper Explores 'iHerd,' A Hierarchical Graph Representation Learning Method
Matthew Girgenti, PhD, assistant professor of psychiatry, is co-author of a paper in PLOS Computational Biology that explores a hierarchical graph representation learning method called iHerd.Source: PLOS Computational Biology
Ramaswamy Praises the 'Nuclear Family,' but Single Parents Say His Comments Hurt
Carmen Black, MD, assistant professor of psychiatry, and a single parent, spoke to USA Today for a story about comments presidential candidate Vivek Ramaswamy made regarding his upbringing in a two-parent household.Source: USA Today
Distribution of CARES Act Provider Relief Funding to Psychiatric Care Organizations
John Havlik, a Yale School of Medicine student, and Jack Tsai, PhD, associate professor adjunct of psychiatry, are first and senior authors, respectively, of a paper in Psychiatric Services that tracked distribution of Coronavirus Aid, Relief, and Economic Security (CARES) Act funding among psychiatrists.Source: Psychiatric Services
Picciotto to Direct Interdepartmental Neuroscience Program
Marina Picciotto, PhD, Charles B. G. Murphy Professor of Psychiatry and Professor in the Child Study Center, of Neuroscience and of Pharmacology, has been appointed director of the Interdepartmental Neuroscience Program, the largest doctoral program in the biological and biomedical sciences at Yale.