Within tarantula venom, new hope for safe and novel painkillers found
Screening more than 100 spider toxins, Yale researchers identified a protein from the venom of the Peruvian green velvet tarantula that blunts activity in pain-transmitting neurons. The findings, reported in the March 3 issue of the journal Current Biology, show the new screening method used by the scientists has the potential to search millions of different spider toxins for safe pain-killing drugs and therapies.
Lighting a new path to understanding the 'language' of the brain
School of Medicine researchers have developed a new technique that allows them to non-invasively and simultaneously measure electrical activity in many neurons in a living organism, a prerequisite for understanding the complex language of the brain. The technique, described in the Aug. 8 issue of the journal Cell, involves inserting a fluorescent protein that varies in intensity in response to changes in electrical signals into neurons and recording the changing light with optical sensors.
Neural Patterns Differentiate Traumatic From Sad Autobiographical Memories in PTSD
Investigators from Yale and Mount Sinai schools of medicine studied the neural activity of 28 people diagnosed with post-traumatic stress disorder (PTSD). They found that autobiographical memories for sad and neutral memories are processed differently in the brain than for traumatic memories. The findings were published in Nature Neuroscience. The co-senior author is Ilan Harpaz-Rotem, PhD, professor of psychiatry and of psychology at Yale School of Medicine.
Thalidomide Use In Gastrointestinal Bleeding
Angiodysplasia, a type of benign vascular lesion made up of dilated blood vessels, is a common source of gastrointestinal bleeding from the small intestine. A recent editorial from Yale Internal Medicine’s Loren Laine, MD, professor of medicine and chief of digestive diseases, in the New England Journal of Medicine highlights novel findings from a recent multicenter, double-blind, randomized clinical trial evaluating thalidomide in the treatment of angiodysplasia-related bleeding.
The Effect of 10 Versus 20 Minutes of Mindfulness Meditation on State Mindfulness and Affect
Hedy Kober, PhD, associate professor of psychiatry and of psychology, is senior author of a paper in Scientific Reports that found a single session of mindfulness meditation improves state mindfulness regardless of whether sessions are 10 or 20 minutes long.Source: Scientific Reports
Implicit Bias From Providers Inhibits HCV Treatment
A new study reveals significant insights into the challenges that can occur for hepatitis C virus (HCV) micro-elimination efforts in people with HIV (PWH). Due to the opioid epidemic, the prevalence of co-infection with HIV and HCV has been increasing. If left untreated, HCV infection can lead to liver damage, cancer, and death. Although HIV requires lifelong therapy, HCV can be cured with a few months of oral medications.
Alcohol Research Conference Fosters Collaboration Across Specialties
Now in its second year, the Yale Conference for Alcohol Research and Education (YCARE) was held on September 30, 2023. Offering a comprehensive agenda of talks, panel discussions, and poster presentations, the all-day event brought together Yale's researchers, clinicians, and other stakeholders under the banner of alcohol research. Bubu Banini, MD, PhD, assistant professor of medicine (digestive diseases), Yale School of Medicine (YSM), spearheaded the conference, along with co-directors David Fiellin, MD, professor of medicine (general medicine) and emergency medicine, YSM, and public health, Yale School of Public Health; Graeme Mason, PhD, professor of radiology and biomedical imaging and of psychiatry, YSM; and Sherry McKee, PhD, professor of psychiatry, YSM.
Electronic Nicotine Delivery Systems and E-Liquid Modifications to Vape Cannabis Depicted in Online Videos
Rachel Ouellette, PhD; Sophia Selino, BA; and Grace Kong, PhD, are co-authors of a paper in JAMA Network Open that analyzed YouTube videos for use, modification, and marketing of electronic nicotine delivery systems to vape cannabis.Source: JAMA Network Open
Yale Study Finds Genetic Links Between Some Health Conditions and PTSD
A new study led by Yale Department of Psychiatry researchers and published in JAMA Psychiatry has identified numerous physical health conditions, particularly diseases of the cardiovascular and respiratory systems, that have genetic links to post-traumatic stress disorder (PTSD). Gita Pathak, PhD, and Renato Polimanti, PhD, are first and senior authors, respectively.
Yale Contributions Shape ASN Kidney Week 2023
In the world of nephrology, there's one event that stands out above the rest, drawing thousands of professionals from around the globe—the American Society of Nephrology's Kidney Week. This annual event features a rich array of sessions, speakers, and insights into the ever-evolving field of kidney care. This year, Kidney Week takes place in Philadelphia, Pa., with over 12,000 planned attendees.
Screening for Intimate Partner Violence Experience and Use in the Veterans Health Administration
A first-of-its-kind study by Yale School of Medicine researchers revealed high amounts of intimate partner violence involvement among adult patients seeking mental health services at veterans’ health care facilities in the United States.
Using Interactive Animated Flipped-classroom Modules to Better Teach Dementia Care
A new medical education study demonstrates how a modular, flipped-classroom curriculum using character animations can better train nursing students to deliver effective care to patients with dementia and other cognitive disorders.
Improved Measurement of Glomeruli in Kidney Scarring
A new research study explores patterns in kidney structures to better understand focal segmental glomerulosclerosis, a condition where scar tissue develops in parts of the kidney. These findings offer insights into more accurate measurement of kidney structures like the glomeruli, which could ultimately lead to improved diagnosis and prognosis for patients with focal segmental glomerulosclerosis.
Preventing Worsening Asthma in Inner-city Patients
A new perspective published in the Annals of Allergy, Asthma, and Immunology sheds light on strategies to prevent asthma exacerbations in inner-city patients. Previous research has demonstrated that living in an inner-city is an independent risk factor for Emergency Department visits and hospitalizations from asthma.
Immune Sensing of Allergens Promotes Avoidance Behavior
A new study published in Nature demonstrates how the immune system plays a role in the development of behaviors to avoid food allergens. Previous research has suggested that the immune system may be involved in behavioral modification beyond simply protecting the body from infectious diseases.
Genome-wide Association Studies and Cross-population Meta-analyses Investigating Short and Long Sleep Duration
Joel Gelernter, MD, Foundations Fund Professor of Psychiatry and Professor of Genetics and of Neuroscience, is senior author of a paper in Nature Communications that presents genome-wide association studies of short and long sleep duration in adults.Source: Nature Communications
A Single Dose of Psilocybin Boosts Neuroplasticity and Reduces Depression Symptoms
Patrick Skosnik, PhD, associate professor of psychiatry, and Deepak D'Souza, MD, Albert E Kent Professor of Psychiatry, are first and senior authors, respectively, of a paper in Journal of Psychopharmacology that provides evidence that psilocybin induces lasting changes in neuroplasticity and that these changes are linked to improvements in depression symptoms.Source: PsyPost
Investigators Launch Study Aimed at Accelerating Understanding of Bipolar Disorder
A multidisciplinary team of researchers based at Yale will launch a series of studies aimed at accelerating understanding of bipolar disorder and generating new and more effective treatments. Hilary Blumberg, MD, John and Hope Furth Professor of Psychiatric Neuroscience and Professor of Psychiatry, and in the Child Study Center and of Radiology and Biomedical Imaging, will lead the research team.