When lung cancer and breast cancer relapse, they often metastasize in the brain. The tumors that arise in the brain develop novel characteristics, differences that oft en confer resistance to existing drug therapies and create opportunities for new detection and treatment approaches for Yale Cancer Center researchers.
- May 03, 2019
Katerina Politi, PhD and Don Nguyen, PhD, members of the Signal Transduction Research Program at Yale Cancer Center (YCC), have received a 5-year, nearly $4 million National Cancer Institute (NCI) grant to support Lung Cancer research.
- April 27, 2019
New technique by Yale Cancer Center scientists may improve detection and treatment of advanced brain cancer
In a new study, Yale Cancer Center scientists have demonstrated a powerful method to analyze how tumor cells are altered as they metastasize to the brain.
- February 28, 2017Source: Yale Daily News
In a recent study, Yale researchers discovered a mechanism co-opted by lung cancer cells in order to spread to the brain. Lung cancer is the No. 1 cause of cancer-related deaths, killing more people than breast, colon and prostate cancers worldwide, according to Don Nguyen, a professor of pathology at the Yale School of Medicine and a senior author of the study. The most frequentluy diagnosed form of lung cancer is lung adenocarcinoma, which originates in the lungs but is most dangerous after it has migrated to other parts of the body in a process known as metastasis. LUAD metastasis to the brain is often deadly and can leave survivors with heightened risk of relapse and a far lower quality of life, Nguyen said. Metastasis is one of cancer’s many “black boxes” Nguyen said, in that very little is known about the mechanisms that allow this process to take place.
- February 15, 2017
More people die of lung cancer each year than breast, colon, and prostate cancers combined. One particularly lethal form of the disease is lung adenocarcinoma or LUAD, which afflicts both smokers and non-smokers. In many patients diagnosed with LUAD, tumors cells have already spread to the brain, leading to decreased quality of life and low survival rates. A Yale Cancer Center research team conducted a study to determine how those tumor cells manage to grow outside the lungs.
- February 09, 2017
A Yale-led research team identified how insulin-producing cells that are typically destroyed in type 1 diabetes can change in order to survive immune attack. The finding may lead to strategies for recovering these cells in diabetic patients, said the researchers.
- April 22, 2016
Congratulations Dr. Don Nguyen, who was awarded a Department of Defense IDEA Award! The award provides 3 years of support for "conceptually innovative, high-risk/high-reward research.” With this award, Dr. Nguyen’s laboratory will explore how novel therapies can be used to prevent metastasis from lung cancer. Previously, Dr. Nguyen identified a gene regulator critical for breast cancer metastasis to the lung.
- April 28, 2014
William Cheung, postdoctoral associate in pathology, won a $100,000 award from Uniting Against Lung Cancer (UALC) to support his research into finding druggable pathways to treat and prevent cancer metastasis.
- February 27, 2014
Yale Cancer Center researchers have identified a regulator of gene expression that is responsible for the progression of breast cancer and its metastasis to the lung. The study appears online in Cell Reports.
- November 26, 2013
On November 25th Yale Cancer Center held their fifth annual Conclave at the New Haven Lawn Club.