Nils Petersen, MD, PhD, MSc
Associate Professor TermCards
About
Research
Overview
Medical Research Interests
Stroke; Ultrasonography
Publications
2024
Continuous versus Intermittent Blood Pressure Monitoring in Postpartum Preeclampsia with Severe Features
Martinez H, Haghighi N, van Wingerden A, Kirschner M, Booker W, Bello N, Petersen N, Miller E. Continuous versus Intermittent Blood Pressure Monitoring in Postpartum Preeclampsia with Severe Features. American Journal Of Perinatology 2024 PMID: 39486401, DOI: 10.1055/a-2457-2781.Peer-Reviewed Original ResearchPostpartum patientsBlood pressureProportion of patientsSevere featuresBlood pressure monitoringIntermittent monitoringPostpartum preeclampsiaPaired t-testArterial pressureFinger plethysmographyPreeclampsiaBP measurement methodsClinical protocolsMcNemar testBP valuesBP monitoringBrachial BPPatientsPressure monitoringBP measurementsOscillometric devicePostpartumMmHgT-testSBPEndovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score.
Galecio-Castillo M, Farooqui M, Guerrero W, Ribo M, Hassan A, Jumaa M, Divani A, Abraham M, Petersen N, Fifi J, Malik A, Siegler J, Nguyen T, Sheth S, Linares G, Janjua N, Soomro J, Quispe-Orozco D, Olivé-Gadea M, Tekle W, Zaidi S, Sabbagh S, Barkley T, Prasad A, De Leacy R, Abdalkader M, Salazar-Marioni S, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal D, Yoo A, Sarraj A, Jovin T, Ortega-Gutierrez S. Endovascular Treatment of Patients With Acute Ischemic Stroke With Tandem Lesions Presenting With Low Alberta Stroke Program Early Computed Tomography Score. Journal Of The American Heart Association 2024, 13: e035977. PMID: 39508172, DOI: 10.1161/jaha.124.035977.Peer-Reviewed Original ResearchLower Alberta Stroke Program Early Computed Tomography ScoreAlberta Stroke Program Early Computed Tomography ScoreModified Rankin ScaleComputed Tomography ScoreSymptomatic intracranial hemorrhageEndovascular thrombectomyIntracranial hemorrhageTandem lesionsBaseline Alberta Stroke Program Early Computed Tomography ScoreAnterior circulation tandem lesionsModified Rankin Scale shiftModified Rankin Scale 0 to 2Score 0 to 2Safety of endovascular thrombectomySymptomatic intracranial hemorrhage riskOdds of symptomatic intracranial hemorrhageEndovascular treatment of patientsAcute large-vessel occlusionInternal carotid artery stenosis/occlusionIntracranial hemorrhage riskRetrospective analysis of dataProportion of patientsTreatment of patientsOrdinal modified Rankin ScaleAssociated with reduced oddsPostpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia
van Wingerden A, Katsidoniotaki M, Haghighi N, Almonte C, Martinez H, Valdes E, Castro P, Alian A, Booker W, Bello N, Marshall R, Kougioumtzoglou I, Petersen N, Miller E. Postpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia. Hypertension 2024, 81: 2510-2519. PMID: 39403810, PMCID: PMC11578794, DOI: 10.1161/hypertensionaha.124.23321.Peer-Reviewed Original ResearchBlood pressure variabilityChronic hypertensionHeart rate variabilitySuperimposed preeclampsiaBlood pressurePressure variabilityProspective cohort of womenTime-domain heart rate variabilityAssociated with autonomic dysregulationCohort of womenRatio of heart rate variabilityHigh blood pressure variabilityRate variabilityPreeclampsia groupLow-/high-frequency ratioPostpartum patientsPostpartum controlsPreeclampsiaRR interval differencesProspective cohortHigh-frequency heart rate variabilityAutonomic dysregulationPostpartum womenFinger plethysmographyWeeks postpartumCervical Dissection in Patients With Tandem Lesions Is Associated With Distal Embolism and Lower Recanalization Success
Galecio-Castillo M, Guerrero W, Hassan A, Farooqui M, Jumaa M, Divani A, Abraham M, Petersen N, Fifi J, Malik A, Siegler J, Nguyen T, Sheth S, Yoo A, Linares G, Janjua N, Quispe-Orozco D, Olivé-Gadea M, Tekle W, Zaidi S, Sabbagh S, Barkley T, Prasad A, De Leacy R, Abdalkader M, Salazar-Marioni S, Soomro J, Gordon W, Turabova C, Rodriguez-Calienes A, Dibas M, Mokin M, Yavagal D, Ribo M, Jovin T, Ortega-Gutierrez S. Cervical Dissection in Patients With Tandem Lesions Is Associated With Distal Embolism and Lower Recanalization Success. Stroke 2024, 55: 1808-1817. PMID: 38913799, DOI: 10.1161/strokeaha.123.046148.Peer-Reviewed Original ResearchConceptsInternal carotid arteryCervical internal carotid arteryDistal embolizationModified ThrombolysisTandem lesionsMulticenter retrospective cohort studyParenchymal hematoma type 2Internal carotid artery stenosis/occlusionModified Rankin Scale scoreSymptomatic intracranial hemorrhageInverse probability of treatment weightingCerebral Infarction scoreCervical ICA dissectionRetrospective cohort studyProbability of treatment weightingRankin Scale scoreAssociated with higher ratesFunctional independenceRates of hypertensionAssociated with distal embolizationSelf-expanding stentsDissection etiologyRisk of distal embolizationICA occlusionCervical dissectionAutomated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion
Mak A, Matouk C, Avery E, Behland J, Haider S, Frey D, Madai V, Vajkoczy P, Griessenauer C, Zand R, Hendrix P, Abedi V, Sanelli P, Falcone G, Petersen N, Sansing L, Sheth K, Payabvash S, Malhotra A. Automated detection of early signs of irreversible ischemic change on CTA source images in patients with large vessel occlusion. PLOS ONE 2024, 19: e0304962. PMID: 38870240, PMCID: PMC11175522, DOI: 10.1371/journal.pone.0304962.Peer-Reviewed Original ResearchConceptsDiffusion-weighted imagingLarge vessel occlusionIrreversible ischemic changesPoor functional outcomeFunctional outcomesIschemic changesInfarct volumeAlberta Stroke Program Early CT ScorePredicting poor functional outcomeVessel occlusionFollow-up diffusion-weighted imagingAnterior circulation LVO strokeCTA source imagesReceiver operating characteristic curveExpert human readersPredicting final infarctionASPECTS regionsAdmission CTANon-inferior performanceBaseline CTACT scoreFinal infarctEndovascular therapyHU attenuationValidation cohortUse of a dedicated open transcarotid access system for neurovascular disease
Sujijantarat N, Renedo D, Antonios J, Koo A, Amllay A, Nowicki K, Cord B, Hebert R, de Havenon A, Sheth K, Petersen N, Matouk C. Use of a dedicated open transcarotid access system for neurovascular disease. Journal Of NeuroInterventional Surgery 2024, jnis-2024-021599. PMID: 38719442, DOI: 10.1136/jnis-2024-021599.Peer-Reviewed Original ResearchExtracranial carotid stenosisTranscarotid artery revascularizationNeurovascular diseasesCarotid stenosisDatabase of consecutive patientsNeurovascular pathologyTreatment of neurovascular diseasesAccess-related complicationsTreatment of neurovascular pathologiesOff-label useCarotid flow reversalConsecutive patientsRetrospective reviewIntracranial atherosclerotic diseasePeriprocedural complicationsEndovascular treatmentArtery revascularizationProcedural characteristicsArterial sheathCarotid diseaseAcademic centersIntracranial aneurysmsPatientsTranscarotid approachTransradial approachImpact of sleep quality and physical activity on blood pressure variability
de Havenon A, Falcone G, Rivier C, Littig L, Petersen N, de Villele P, Prabhakaran S, Kimberly W, Mistry E, Sheth K. Impact of sleep quality and physical activity on blood pressure variability. PLOS ONE 2024, 19: e0301631. PMID: 38625967, PMCID: PMC11020843, DOI: 10.1371/journal.pone.0301631.Peer-Reviewed Original ResearchConceptsSleep qualityPhysical activityOdds ratioCohort of community-dwelling adultsCommunity-dwelling adultsExcess relative riskBlood pressure variabilityExamined sleep qualityPoor sleep qualitySystolic blood pressure standard deviationSleep interruptionBody mass indexPhysical inactivityPrimary study outcomeStep countsImpact of sleep qualityLowest tertileRelative riskHigh blood pressure variabilityHome measurement devicesActivity levelsExposure statusPoor sleepMass indexStudy outcomesQuantitative Assessment of Reperfusion Impact on Cerebral Edema and Functional Outcomes in Large-vessel Occlusion Stroke Patients (S23.003)
Olexa M, Begunova Y, Dhar R, Matouk C, Sheth K, Gutierrez S, De Havenon A, Petersen N. Quantitative Assessment of Reperfusion Impact on Cerebral Edema and Functional Outcomes in Large-vessel Occlusion Stroke Patients (S23.003). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205719.Peer-Reviewed Original ResearchExploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004)
Olexa M, Begunova Y, Gilmore E, Kim J, Herman A, Beekman R, Magid-Bernstein J, Matouk C, Sheth K, Miller E, Gutierrez S, De Havenon A, Sansing L, Petersen N. Exploring the Relationship Between Cerebrospinal Fluid Interleukin-6 and Cerebral Autoregulation After Subarachnoid Hemorrhage (S23.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000205692.Peer-Reviewed Original ResearchDifferent Response to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage (P10-2.004)
Hawkes M, Clocchiatti-Tuozzo S, Rivier C, Qureshi A, Matouk C, Petersen N, De Havenon A, Sheth K, Falcone G. Different Response to Blood Pressure Reduction in Lobar and Deep Intracerebral Hemorrhage (P10-2.004). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206366.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis (CAPTIVA)
HIC ID2000031893RoleSub InvestigatorPrimary Completion Date03/07/2028Recruiting ParticipantsGenderBothAge30 years - 80 yearsRegulating Blood Pressure During Recovery from Intracerebral Hemorrhage and Ischemic Stroke (REDUCE)
HIC ID2000029811RoleSub InvestigatorPrimary Completion Date01/31/2025Recruiting ParticipantsGenderBothAge18+ yearsBlood PREssure Augmentation in Large-vessel Occlusion Stroke Study (PRESS)
HIC ID2000022525RolePrincipal InvestigatorPrimary Completion Date04/30/2019Recruiting ParticipantsGenderBothAge18+ yearsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
HIC ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
Clinical Care
Overview
Nils Petersen, MD, PhD, is a neurointensivist in the neuroscience intensive care unit (NICU) of Yale New Haven Hospital. He treats life-threatening diseases that involve the brain, spinal cord and nerves, from stroke to central nervous system infections, neuromuscular diseases and neurosurgical post-operative care. “To be a skilled neurologist requires not only knowledge of how the brain works and the latest treatments,” he says, “but also the clinical acumen to pick up subtle exam findings, interpret complicated histories and apply critical thinking skills to compose the best treatment plan for each patient.”
He was recruited by Yale in 2014 to design and implement a state-of-the-art neurovascular ultrasound lab. “Hospitalization after stroke or in the NICU represents an important and vulnerable time for both patients and families, a time during which physicians have the most impact,” he says. “I feel privileged to be a part of this journey for my patients and their families, a journey that continues to inspire me both personally and scientifically on a regular basis.”
An assistant professor at Yale School of Medicine, Dr. Petersen hopes his research on brain blood flow and how it is affected by neurologic injury, particularly stroke, will help doctors improve functional outcomes after stroke.
Clinical Specialties
Neurology; Stroke; Neurocritical Care
Board Certifications
Neurocritical Care
- Certification Organization
- United Council for Neurologic Subspecialties
- Original Certification Date
- 2015
News
News
- January 31, 2023
Yale Study Links Genetics and Blood Pressure Control in Stroke Survivors
- October 20, 2020Source: Futurity
Quicker Treatment Could Save Older Stroke Patients
- October 07, 2020
Improvements in Stroke Treatment Could Save More Lives
- October 01, 2020
NINDS Grant Awarded to Nils Petersen
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