Lohith Gowda, MD, MRCP
Assistant Professor of Medicine (Hematology)Cards
About
Research
Overview
Targeted therapy; Transfusion Associated Immunomodulation, Immunotherapy, Cellular Therapy, Regenerative Medicine
Medical Research Interests
Anemia, Aplastic; Blood Transfusion; Bone Marrow Diseases; Hematopoietic Stem Cell Transplantation; Immunotherapy; Leukemia; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Primary Myelofibrosis
Publications
2025
Outcomes of older adults and frail patients receiving idecabtagene vicleucel: a CIBMTR study
Akhtar O, Oloyede T, Brazauskas R, Afrough A, Hashmi H, Sidana S, Ahmed N, Bye M, Hansen D, Ferreri C, Dhakal B, Dhanda D, Harrison M, Kitali A, Landau H, Mirza A, Patel J, Patwardhan P, Qazilbash M, Patel K, Nishihori T, Ganguly S, Gowda L, Anderson L, Pasquini M, Usmani S, Freeman C. Outcomes of older adults and frail patients receiving idecabtagene vicleucel: a CIBMTR study. Blood Advances 2025, 9: 1587-1592. PMID: 39786391, DOI: 10.1182/bloodadvances.2024014970.Peer-Reviewed Original ResearchUS Geriatric Assessment Practices for Older Adults Undergoing Hematopoietic Cell Transplantation or CAR T- cell therapy: An ASTCT Physician Survey from the Aging Special Interest Group and Committee on Practice Guidelines
Munshi P, Olin R, Wall S, McCurdy S, Al-Juhaishi T, Baker J, Bhatt V, Chokr N, Dahi P, DeFilipp Z, Espinoza-Gutarra M, Farhan S, Gowda L, Hamilton B, Inamoto Y, Jayani R, Kharfan-Dabaja M, Lin R, Meyers G, Mishra A, Murthy H, Nawas M, Rosko A, Ruiz M, Sorror M, Sung A, Carpenter P, Hamadani M, Artz A. US Geriatric Assessment Practices for Older Adults Undergoing Hematopoietic Cell Transplantation or CAR T- cell therapy: An ASTCT Physician Survey from the Aging Special Interest Group and Committee on Practice Guidelines. Transplantation And Cellular Therapy 2025 PMID: 39961473, DOI: 10.1016/j.jtct.2025.02.014.Peer-Reviewed Original ResearchHematopoietic cell transplantationT-cell therapyCAR-T cell therapyCAR-TCell transplantationGeriatric assessmentCellular therapyChimeric antigen T-cell therapyAmerican Society for TransplantationPromote risk stratificationAllo-HCTRisk stratificationCell therapyOlder patientsRoutine GAOlder adultsGa uptakeTherapyPhysician practice patternsTransplantationPractice patternsClinical support staffCross-sectional surveyPhysician membersDomain of GAOutcomes after Allogeneic Transplantation with Reduced Intensity Conditioning and Post Transplant Cyclophosphamide GvHD Prophylaxis in T-Cell Lymphomas: A Single Institution Experience
Taborda C, Isufi I, Bar N, Sethi T, Gowda L, Perreault S, Roberts K, Seropian S, Foss F. Outcomes after Allogeneic Transplantation with Reduced Intensity Conditioning and Post Transplant Cyclophosphamide GvHD Prophylaxis in T-Cell Lymphomas: A Single Institution Experience. Transplantation And Cellular Therapy 2025, 31: s393-s394. DOI: 10.1016/j.jtct.2025.01.606.Peer-Reviewed Original ResearchAcute graft-versus-host diseaseReduced-intensity conditioningGraft-versus-lymphomaNon-relapse mortalityPosttransplant cyclophosphamideT-cell lymphomaAllo-SCTOverall survivalGVHD prophylaxisT cellsAssociated with improved overall survivalTacrolimus-based GVHD prophylaxisAllogeneic stem cell transplantationGraft-versus-host diseaseAggressive T-cell lymphomaT-cell lymphoma patientsHaplo-identical transplantationReduced intensity conditioningImproved overall survivalRelapse-free survivalMedian follow-upSingle-center experienceReduce treatment toxicityStem cell transplantationSingle institution experienceTSC-100 and TSC-101 Demonstrate the Potential to Reduce Relapse Rates and Increase Relapse-Free Survival in Patients with AML, ALL, or MDS Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT) with Reduced Intensity Conditioning (RIC): Preliminary Results from the Phase 1 Alloha Trial (NCT05473910)
Al Malki M, Keyzner A, Popat U, Chen Y, Suh H, Jain T, Solh M, Snow A, Pineiro L, Gill S, Gowda L, Uberti J, White T, Wang Y, Nguyen C, Louis C, Chattopadhyay S, Matzko M, Reshef R. TSC-100 and TSC-101 Demonstrate the Potential to Reduce Relapse Rates and Increase Relapse-Free Survival in Patients with AML, ALL, or MDS Undergoing Allogeneic Hematopoietic Cell Transplantation (HCT) with Reduced Intensity Conditioning (RIC): Preliminary Results from the Phase 1 Alloha Trial (NCT05473910). Transplantation And Cellular Therapy 2025, 31: s59-s60. DOI: 10.1016/j.jtct.2025.01.096.Peer-Reviewed Original ResearchRIC HCTReduced intensity conditioningHematopoietic cell transplantationRelapse-free survivalPost-HCTControl subjectsControl armDonor chimerismGrade II-IV acute graft-versus-host diseaseII-IV acute graft-versus-host diseaseT cell receptor-engineered T cellsAcute graft-versus-host diseasePhase 1 dose-escalation studyIncreased relapse-free survivalGraft-versus-host diseaseAllogeneic hematopoietic cell transplantationNon-relapse deathPost-HCT MRDEngineered T cellsCytokine release syndromeData cut-offMonths post-HCTReducing relapse ratesYears post-HCTAssessment of efficacy
2024
Non-selective b adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic cell transplants.
Nishino J, Hu W, Kishtagari A, Shen B, Gao X, Blackman C, Kassim A, Marneni N, Cherukuri A, Vittrup R, Kalkan F, Shah R, Ahn C, Gao A, Ahmedrabie A, Collins R, Zeidan A, Bidikian A, Gowda L, Shaffer B, Madanat Y, Zhao Z, Chung S, Morrison S. Non-selective b adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic cell transplants. Cancer Discovery 2024, of1-of19. PMID: 39786370, DOI: 10.1158/2159-8290.cd-24-0719.Peer-Reviewed Original ResearchAllogeneic hematopoietic cell transplantationHematopoietic cell transplantationB-blockersCell transplantationHematopoietic regenerationGraft-versus-host disease prophylaxisAutologous hematopoietic cell transplantationDelayed platelet engraftmentImpaired hematopoietic regenerationPost-transplant chemotherapyGraft-versus-hostAdrenergic receptor signalingBone marrow regenerationInhibitory effectPlatelet engraftmentInhibit engraftmentReceptor inhibitorsDisease prophylaxisMarrow regenerationMouse hematopoiesisHematopoietic cellsEngraftmentLarger dosesReceptor signalingPeripheral nervesReal World Comparison of Efficacy and Safety of Fludarabine-Versus Bendamustine-Based Lymphodepleting Chemotherapy for CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy in Relapse/Refractory (r/r) Large B-Cell Lymphoma (LBCL)
Ali A, Ahmed N, Kim S, Bye M, Mirza S, Sieg A, Strouse C, Nadiminti K, Pophali P, Kamble R, Gowda L, Turtle C, Phillips C, Pasquini M, Ahmed S, Ganguly S, Moskop A. Real World Comparison of Efficacy and Safety of Fludarabine-Versus Bendamustine-Based Lymphodepleting Chemotherapy for CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy in Relapse/Refractory (r/r) Large B-Cell Lymphoma (LBCL). Blood 2024, 144: 71. DOI: 10.1182/blood-2024-200269.Peer-Reviewed Original ResearchCD19 chimeric antigen receptorProgression-free survivalOverall response rateProlonged cytopeniasOverall survivalLiso-celTisa-celFludarabine groupLymphodepleting chemotherapyLD regimenT cellsCAR T cell productCD19 CAR-T therapyMultivariate analysisCD19 CAR-T cellsProbability of overall survivalLower CrsLD regimensCAR-T cellsT-cell therapyChimeric antigen receptorCAR-T therapyMedian follow-upT cell expansionT cell productionTSC-100 and TSC-101 Demonstrate the Potential to Reduce Relapse Rates and Increase Relapse-Free Survival in Patients with AML, ALL, or MDS Undergoing Allogeneic HCT with Reduced Intensity Conditioning (RIC): Preliminary Results from the Phase 1 Alloha Trial
Al Malki M, Keyzner A, Popat U, Chen Y, Suh H, Jain T, Solh M, Snow A, Gill S, Gowda L, Uberti J, Buonomo E, Wang Y, Nabilsi N, White T, Nguyen C, Murray J, MacBeath G, Louis C, Chattopadhyay S, Matzko M, Reshef R. TSC-100 and TSC-101 Demonstrate the Potential to Reduce Relapse Rates and Increase Relapse-Free Survival in Patients with AML, ALL, or MDS Undergoing Allogeneic HCT with Reduced Intensity Conditioning (RIC): Preliminary Results from the Phase 1 Alloha Trial. Blood 2024, 144: 924. DOI: 10.1182/blood-2024-201526.Peer-Reviewed Original ResearchReduced intensity conditioningRelapse-free survivalPost-HCTDonor chimerismTreatment armsFollow-upControl armMalignant lineagesGrade 2-4 acute graft-versus-host diseaseT cell receptor-engineered T cellsControl subjectsIncreased relapse-free survivalGraft-versus-host diseaseMedian time to relapseControl arm subjectsNon-relapse deathPost-HCT MRDComplete donor chimerismDonor-derived cellsEngineered T cellsMedian follow-upTime to relapseCD3+ cellsPhase 1 studyARMS subjectsIncidence of bacterial blood stream infections in patients with acute GVHD
Wallis W, Gulbis A, Wang T, Lee C, Sharma A, Williams K, Nishihori T, Prestidge T, Gowda L, Byrne M, Krem M, MacMillan M, Kitko C, Pidala J, Spellman S, Lee S, Alousi A. Incidence of bacterial blood stream infections in patients with acute GVHD. Bone Marrow Transplantation 2024, 60: 52-57. PMID: 39420192, PMCID: PMC11724748, DOI: 10.1038/s41409-024-02426-9.Peer-Reviewed Original ResearchBacterial bloodstream infectionsHematopoietic stem cell transplantationAcute GVHDNon-relapse mortalityGrade II-IV acute GVHDAllogeneic hematopoietic stem cell transplantationGrade III/IV acute GVHDBacterial blood stream infectionsAssociated with worse survivalStem cell transplantationBlood stream infectionsHigh-risk populationGVHD treatmentNeutrophil engraftmentBloodstream infectionsWorse survivalCell transplantationGI involvementOrgan involvementPost-transplantationPost-engraftmentRisk populationHigh riskPatientsGVHDP-088 Evaluating T-cell Fitness Pre B-Cell Maturation Antigen (BCMA)-Targeted T-Cell Redirection Therapies (TRT) as a Predictive Marker for Efficacy/Toxicity in Relapsed/Refractory Multiple Myeloma (RRMM)
Theprungsirikul P, Yu M, Liu Y, Rall K, Matthews M, Neparidze N, Parker T, Browning S, Anderson T, Stevens E, Foss F, Gowda L, Pillai M, Isufi I, Seropian S, Mirza S, Bar N. P-088 Evaluating T-cell Fitness Pre B-Cell Maturation Antigen (BCMA)-Targeted T-Cell Redirection Therapies (TRT) as a Predictive Marker for Efficacy/Toxicity in Relapsed/Refractory Multiple Myeloma (RRMM). Clinical Lymphoma Myeloma & Leukemia 2024, 24: s92-s93. DOI: 10.1016/s2152-2650(24)01991-8.Peer-Reviewed Original ResearchAssociations of T-cell fitness prior to B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor T-cell (CART) and bispecific T-cell engager (BiTE) therapies and efficacy/toxicity in relapsed/refractory multiple myeloma (RRMM).
Theprungsirikul P, Yu M, Rall K, Matthews M, Neparidze N, Parker T, Browning S, Anderson T, Stevens E, Foss F, Gowda L, Pillai M, Isufi I, Seropian S, Mirza S, Bar N. Associations of T-cell fitness prior to B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor T-cell (CART) and bispecific T-cell engager (BiTE) therapies and efficacy/toxicity in relapsed/refractory multiple myeloma (RRMM). Journal Of Clinical Oncology 2024, 42: 7549-7549. DOI: 10.1200/jco.2024.42.16_suppl.7549.Peer-Reviewed Original ResearchChimeric antigen receptor T cellsRelapsed/refractory multiple myelomaT cell fitnessHigh-risk cytogeneticsCytokine release syndromeNon-respondersExtramedullary diseaseT cellsPeripheral blood prior to treatmentInternational Myeloma Working Group criteriaNR groupBlood prior to treatmentBispecific T-cell engagerMedian follow-up timeMedian prior linesT-cell therapyPost-treatment follow-upT-cell engagersT cell influxT-cell %Working Group criteriaYale Cancer CenterMann-Whitney U testResponse to disease progressionIdecabtagene vicleucel
Clinical Trials
Current Trials
A Multi-center Single Arm Phase II Study to Evaluate the Safety and Efficacy of Genetically Engineered Autologous Cells Expressing Anti-CD20 and Anti-CD19 Specific Chimeric Antigen Receptor in Subjects With Relapsed and/or Refractory Diffuse Large B Cell Lymphoma
HIC ID2000028478RoleSub InvestigatorPrimary Completion Date07/30/2023Recruiting ParticipantsA Phase 2, Single-arm, Multi-center Trial to Determine the Efficacy and Safety of JCAR017 in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma or With Other Aggressive B-Cell Malignancies
HIC ID2000027145RoleSub InvestigatorPrimary Completion Date09/28/2028Recruiting ParticipantsManaged Access Program (MAP) to Provide Access to CTL019, for ALL or DLBCL Patients With Out of Specification Leukapheresis Product and/or Manufactured Tisagenlecleucel Out of Specification for Commercial Release
HIC ID2000025634RoleSub InvestigatorPrimary Completion Date07/06/2023Recruiting Participants
Academic Achievements & Community Involvement
Clinical Care
Overview
Lohith Gowda, MD, is a hematologist, which means he studies and treats blood-based diseases and cancers including leukemia and bone marrow failure.
Dr. Gowda’s team includes not just other doctors and scientists but patients and their families. The team meets often to help patients and families navigate the complexities of stem-cell transplant and cellular therapy, all of which are involved in the treatment of blood-based diseases. It is important for patients and families to fully understand options for care in order to make informed decisions, he says.
An active researcher, Dr. Gowda’s work examines the effectiveness of specific strategies for treating blood disorders, as well as their effects on patients’ well-being and long-term care. While transplantation may give patients a new lease on life, dedicated follow-up care for transplant recipients is vital, Dr. Gowda says.
Dr. Gowda is a member of the Royal College of Physicians and has received many awards, including the Young Investigator Award from the Academy of Clinical Laboratory Physicians and Scientists and the American Society of Hematology’s Abstract Achievement Award.
Clinical Specialties
Hematology
Fact Sheets
Acute Myeloid Leukemia (AML)
Learn More on Yale MedicineCAR T-Cell Therapy
Learn More on Yale MedicineMyeloproliferative Neoplasms
Learn More on Yale MedicineMyelodysplastic/Myeloproliferative Neoplasms
Learn More on Yale Medicine
Yale Medicine News
News
News
- March 25, 2024
Yale’s Post ASH Review
- November 28, 2023
Yale Cancer Center Experts Present New Research at Hematology Annual Meeting
- November 09, 2021
Discoveries & Impact, November 2021
- March 10, 2021
Discoveries & Impact (March 2021)
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