2020
Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response
van den Pol A, Zhang X, Lima E, Pitruzzello M, Albayrak N, Alvero A, Davis J, Mor G. Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response. Virology 2020, 555: 44-55. PMID: 33453650, PMCID: PMC8451984, DOI: 10.1016/j.virol.2020.10.009.Peer-Reviewed Original ResearchConceptsOvarian cancer cellsHuman ovarian cancer cellsLong-term survivalOvarian cancerCancer cellsTreatment of immunocompetent miceKill ovarian cancer cellsMouse ovarian cancer cellsTreatment of ovarian cancerAnti-tumor responsesImmunocompromised nude miceOncolytic actionImmunocompetent miceMetastatic spreadChemotherapeutic paclitaxelFemale cancersPoor survivalNude miceIntraperitoneal injectionCancer growthSurvival extensionVesicular stomatitis virusVSV glycoproteinCancerReduced neurotropism
2016
Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, Davis JN, Gorres KL, Miller G, Paidas MJ, van den Pol AN. Mood stabilizers inhibit cytomegalovirus infection. Virology 2016, 499: 121-135. PMID: 27657833, PMCID: PMC5102808, DOI: 10.1016/j.virol.2016.09.012.Peer-Reviewed Original ResearchConceptsCytomegalovirus infectionAvailable anti-CMV drugsAnti-CMV drugsCommon infectious causeCongenital birth defectsInfected newbornsFetal exposureInfectious causesInfected fetusesMood stabilizersMouse CMVMood disordersImmunocompromised individualsPsychiatric disordersBody weightViral resistanceHuman CMVDevelopmental maturationBirth defectsSpecific inhibitionCMVInfectionValnoctamideDisordersDrugs
1998
Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family
Swerdlow R, Parks J, Davis J, Cassarino D, Trimmer P, Currie L, Dougherty J, Bridges W, Bennett J, Wooten G, Parker W. Matrilineal inheritance of complex I dysfunction in a multigenerational Parkinson's disease family. Annals Of Neurology 1998, 44: 873-881. PMID: 9851431, DOI: 10.1002/ana.410440605.Peer-Reviewed Original ResearchConceptsCybrid linesMaternal descendantsComplex I dysfunctionInherited mtDNA mutationsCybrid cell linesIncreased reactive oxygen species productionReactive oxygen species productionComplex I activityMitochondrial DNAMtDNA mutationsHuman neuroblastoma cellsFamily membersMitochondrial morphologyMtDNACytoplasmic hybridsPaternal descendantsOxygen species productionCybridsGenetic lesionsMatrilineal inheritanceMaternal lineMultiple membersI activityNeuroblastoma cellsEnzyme activity