Henry J. Binder, MD
Professor Emeritus of Medicine (Digestive Diseases)DownloadHi-Res Photo
Cards
Appointments
Digestive Diseases
Primary
Contact Info
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States
About
Titles
Professor Emeritus of Medicine (Digestive Diseases)
Appointments
Digestive Diseases
EmeritusPrimary
Other Departments & Organizations
- Digestive Diseases
- Gastroenterology
- Gastrointestinal Procedure Center
- Global Health Studies
- Internal Medicine
Education & Training
- Postdoctoral Fellow
- Yale University School of Medicine (1965)
- Intern/Resident
- Bellevue Hospital, New York University (1963)
- MD
- New York University (1961)
- BA
- Dartmouth College (1957)
Research
Overview
Dr. Binder's research career has primarily been directed toward the regulation of colonic electrolyte transport and the pathophysiology of diarrhea and the basis for development of new approaches for treatment of diarrhea. These transport studies were primarily in vitro and dissected the cellular mechanisms of Na, C1, K, HCO3 and short-chain fatty acid transport and were supported by NIDDK for 37 years. During the past few years, Dr. Binder has focused his investigative activities toward the establishment of a major modification of oral rehydration solution (ORS) that is based on his prior laboratory studies that demonstrated butyrate-stimulated Na absorption in the colon was cyclic AMP-insensitive. These studies supported by Bill & Melinda Gates Foundation are designed to increase the uptake of ORS with the adaption of an improved formulation with resistant starch (starch that is relatively insensitive to amylase digestion).
Medical Research Interests
Adenosine Triphosphatases; Digestive System Diseases; Epithelial Cells; Fatty Acids, Volatile; Ion Transport
Research at a Glance
Yale Co-Authors
Frequent collaborators of Henry J. Binder's published research.
Publications Timeline
A big-picture view of Henry J. Binder's research output by year.
Research Interests
Research topics Henry J. Binder is interested in exploring.
John Geibel, DSc, MD, AGAF, MS, FRS
Michael Kashgarian, MD, FASN
Biff Forbush, PhD
Emile Boulpaep, MD
Thomas Ardito, BS
Dhanpat Jain, MD
152Publications
5,543Citations
Ion Transport
Fatty Acids, Volatile
Epithelial Cells
Adenosine Triphosphatases
Publications
2014
Su1488 Effect of Native and Acetylated High Amylose Maize Starch on Fecal pH and Short Chain Fatty Acid Concentrations in a Cohort of Children in Southern India
Balamurugan R, Balachandar G, Dharmalingam T, Mortimer E, Gopalsamy G, Woodman R, Alpers D, Manary M, Binder H, Brown I, Young G, Ramakrishna B. Su1488 Effect of Native and Acetylated High Amylose Maize Starch on Fecal pH and Short Chain Fatty Acid Concentrations in a Cohort of Children in Southern India. Gastroenterology 2014, 146: s-482. DOI: 10.1016/s0016-5085(14)61731-5.Peer-Reviewed Original Research
2013
Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon
Barmeyer C, Ye JH, Soroka C, Geibel P, Hingsammer LM, Weitgasser L, Atway D, Geibel JP, Binder HJ, Rajendran VM. Identification of Functionally Distinct Na-HCO3 Co-Transporters in Colon. PLOS ONE 2013, 8: e62864. PMID: 23690961, PMCID: PMC3653958, DOI: 10.1371/journal.pone.0062864.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsNa-HCO3 cotransportDistal colonProximal colonNBC activityNBC isoformsRat colonColonic epithelial cellsCrypt glandsSensitive transporterHCO3- secretionColonHCO3-dependent mechanismEpithelial cellsSaturable processHOE694Isoform 1Basolateral membraneCotransportPCR analysisNorthern blotDIDSMolecular studiesMolecular identityApparent KiCritical role
2012
Preventive Strategy Against Infectious Diarrhea—A Holistic Approach
Motarjemi Y, Steffen R, Binder HJ. Preventive Strategy Against Infectious Diarrhea—A Holistic Approach. Gastroenterology 2012, 143: 516-519. PMID: 22925951, DOI: 10.1053/j.gastro.2012.07.021.Peer-Reviewed Original ResearchCitationsAltmetric
2011
Radiation decreases murine small intestinal HCO3− secretion
Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. Radiation decreases murine small intestinal HCO3− secretion. International Journal Of Radiation Biology 2011, 87: 878-888. PMID: 21689053, DOI: 10.3109/09553002.2011.583314.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsNon-irradiated miceAnion secretionBALB/c miceUpper gastrointestinal tractInhibition of basalWestern blot analysisElectrolyte imbalanceInsensitive currentsC miceJejunal tissueCyclic adenosine monophosphateCotransporter expressionMiceSecretionProtein levelsDiarrheaBlot analysisAdenosine monophosphateCesium-137 sourceBasalFree solutionInhibition
2010
Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea
Binder HJ. Role of Colonic Short-Chain Fatty Acid Transport in Diarrhea. Annual Review Of Physiology 2010, 72: 297-313. PMID: 20148677, DOI: 10.1146/annurev-physiol-021909-135817.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsShort-chain fatty acidsColonic microbiotaProduction of SCFAsOral rehydration solutionYears of ageShort-chain fatty acid transportAdministration of PEGColonic epithelial cellsAcute diarrheaRehydration solutionSCFA synthesisCyclic AMP-independent processFatty acid transportDiarrheaApical membrane NaFluid absorptionEpithelial cellsSCFA productionAcid transportORSFatty acidsMicrobiotaMembrane NaStoolColon
2009
W1646 DSS-Induced Colonic Inflammation Inhibits HCO3-Stimulated But Not Butyrate-Stimulated Na Absorption in Rat Distal Colon
Shanmugam N, Kashgarian M, Binder H, Rajendran V. W1646 DSS-Induced Colonic Inflammation Inhibits HCO3-Stimulated But Not Butyrate-Stimulated Na Absorption in Rat Distal Colon. Gastroenterology 2009, 136: a-709. DOI: 10.1016/s0016-5085(09)63270-4.Peer-Reviewed Original ResearchOrganization of the gastrointestinal system
Binder, H.J.: Organization of the gastrointestinal system. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 883-894, 2009.Peer-Reviewed Original ResearchGastric Function
Binder, H.J.: Gastric Function. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 895-911, 2009.Peer-Reviewed Original ResearchNutrient digestion and absorption
Binder, H.J.: Nutrient digestion and absorption. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 949-979, 2009.Peer-Reviewed Original ResearchIntestinal fluid and electrolyte movement
Binder. H.J.: Intestinal fluid and electrolyte movement. In: Medical Physiology. Edited by Boron, E., and Boulapaep, E.L., Saunders, Philadelphia, 2nd ed. pp 933-948, 2009.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
activity Diarrhea and Oral Rehydration Therapy
ResearchDetails01/01/2008 - PresentIndiaAbstract/SynopsisDevelopment of a major modification of Oral Rehydration Solution (ORS) for the treatment of acute diarrhea.
News
News
- January 09, 2022
Trust Your Gut CME Series Returns for 2022
- November 29, 2018
November 29, 2018 Medical Grand Rounds Recap
- October 09, 2018
Kudos
- July 15, 2013
Registration deadline for Principles of Clinical Research is Monday
Get In Touch
Contacts
Academic Office Number
Office Fax Number
Mailing Address
Yale School of Medicine
Department of Medicine (Digestive Diseases), PO Box 208019
New Haven, CT 06520-8019
United States