Xiaolong Tian
Associate Research Scientist in GeneticsAbout
Research
Publications
2026
3D multi-omics tumour atlases: from technology to biology and clinical translation
Liu M, Villazon J, Forjaz A, Tian X, Fan R, Wang S, Shi L, Wirtz D, Kiemen A. 3D multi-omics tumour atlases: from technology to biology and clinical translation. Nature Reviews Cancer 2026, 1-28. PMID: 42298141, DOI: 10.1038/s41568-026-00940-0.Peer-Reviewed Original ResearchThis study investigates 3D tumour atlases, showing how spatial multi-omics technologies uncover tumour evolution, aiding early cancer detection, risk stratification, and innovative treatment strategies.Rational Design of Immune Gene Therapy Combinations via In Vivo CRISPR Activation Screen of Tumor Microenvironment Modulators.
Zhang F, Dong C, Chow R, Xin S, He E, Feng Y, Zhu L, Mirza D, Tian X, Yang L, Zhou L, Ling X, Han Q, Fan R, Chen S, Wang G. Rational Design of Immune Gene Therapy Combinations via In Vivo CRISPR Activation Screen of Tumor Microenvironment Modulators. Cancer Discovery 2026, 16: 1222-1244. PMID: 41747251, DOI: 10.1158/2159-8290.cd-25-0545.Peer-Reviewed Original ResearchTherapy combinationsTumor microenvironmentAntigen presentationTCR-T cell therapyAnti-tumor immunityAnti-tumor responsesSolid tumors in vivoHostile tumor microenvironmentT cell proliferationT cell activationTumor microenvironment modulationTumors in vivoCAR-TCancer immunotherapyTumor infiltrationMetastatic tumorsTCR-TTherapeutic combinationsSolid tumorsCell therapyCo-StimulationTumorMicroenvironment modulationTNFSF9Activation of genes
2025
Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
Zhang F, Chow R, He E, Dong C, Xin S, Mirza D, Feng Y, Tian X, Verma N, Majety M, Zhang Y, Wang G, Chen S. Author Correction: Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nature Biotechnology 2025, 43: 2068-2068. PMID: 39901026, DOI: 10.1038/s41587-025-02576-1.Commentaries, Editorials and LettersMultiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy
Zhang F, Chow R, He E, Dong C, Xin S, Mirza D, Feng Y, Tian X, Verma N, Majety M, Zhang Y, Wang G, Chen S. Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy. Nature Biotechnology 2025, 43: 2054-2067. PMID: 39820813, DOI: 10.1038/s41587-024-02535-2.Peer-Reviewed Original ResearchAdeno-associated virusTumor microenvironmentImmunosuppressive genesAntitumor efficacyCD8+ T cell infiltrationIn vivo antitumor efficacyCombinatorial cancer immunotherapyImmunosuppressive tumor microenvironmentSyngeneic tumor modelsT cell infiltrationTumor microenvironment remodelingMulti-agent combinationsMultiple tumor typesAntitumor immunityCombinatorial immunotherapyOptimal immunotherapyCancer immunotherapyGene alterationsTumor typesTumor modelReduced neutrophilLiver toxicityShRNA treatmentWhole-transcriptome profilingImmunotherapy
2024
A Novel Targeted Long-read Sequencing Approach Boosts Transcriptomic Profiling
Tian X, Fan R. A Novel Targeted Long-read Sequencing Approach Boosts Transcriptomic Profiling. Genomics Proteomics & Bioinformatics 2024, 22: qzae090. PMID: 39724297, PMCID: PMC11802469, DOI: 10.1093/gpbjnl/qzae090.Peer-Reviewed Original ResearchSpatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues
Bai Z, Zhang D, Gao Y, Tao B, Zhang D, Bao S, Enninful A, Wang Y, Li H, Su G, Tian X, Zhang N, Xiao Y, Liu Y, Gerstein M, Li M, Xing Y, Lu J, Xu M, Fan R. Spatially exploring RNA biology in archival formalin-fixed paraffin-embedded tissues. Cell 2024, 187: 6760-6779.e24. PMID: 39353436, PMCID: PMC11568911, DOI: 10.1016/j.cell.2024.09.001.Peer-Reviewed Original ResearchRNA biologyWhole-transcriptome sequencingMicroRNA regulatory networkSplicing dynamicsDeterministic barcodingRNA speciesRNA processingRNA variantsFFPE tissuesRegulatory networksTranscriptome sequencingSpliced isoformsNon-malignant cellsTumor clonal architecturesClonal architectureGene expressionCellular dynamicsRNAArchival formalin-fixed paraffin-embedded tissueMalignant subclonesFormalin-fixed paraffin-embedded (FFPEFFPE samplesParaffin-embedded (FFPEBiologyHuman lymphomas