Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsTobias Spiller, MD
Assistant Professor Adjunct in PsychiatryDownloadHi-Res Photo
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Assistant Professor Adjunct in Psychiatry
Biography
Dr. Spiller is an Assistant Professor Adjunct in Psychiatry at Yale and a Privatdozent and Junior Research Group Leader at the University of Zurich, Switzerland. He works as a physician at the University Hospital of Psychiatry in Zurich. His research focuses on bridging the gap between individual patient needs and the standardized approaches of evidence-based medicine and mental health research by investigating the complexity of Post-traumatic stress disorder.
Last Updated on April 09, 2025.
Departments & Organizations
Education & Training
- MD
- University of Zurich (2019)
Research
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Overview
Medical Research Interests
Biological Psychiatry; Emergency Services, Psychiatric; Posttraumatic Growth, Psychological; Stress Disorders, Post-Traumatic
ORCID
0000-0002-0107-0743
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tobias Spiller's published research.
Publications Timeline
A big-picture view of Tobias Spiller's research output by year.
Research Interests
Research topics Tobias Spiller is interested in exploring.
Ilan Harpaz-Rotem, PhD, ABPP
Or Duek, PhD
Nachshon Korem
Ifat Levy, PhD
Robert Pietrzak, PhD, MPH
Georgina Gross, PhD
65Publications
1,251Citations
Stress Disorders, Post-Traumatic
Publications
Featured Publications
Unveiling the Structure in Mental Disorder Presentations
Spiller T, Duek O, Helmer M, Murray J, Fielstein E, Pietrzak R, von Känel R, Harpaz-Rotem I. Unveiling the Structure in Mental Disorder Presentations. JAMA Psychiatry 2024, 81: 1101-1107. PMID: 39110437, PMCID: PMC11307158, DOI: 10.1001/jamapsychiatry.2024.2047.Peer-Reviewed Original ResearchCitationsAltmetricConceptsSymptom combinationsNational Institute of Mental Health Data ArchivePosttraumatic stress disorderDiagnostic criteriaHeterogeneity of symptomsSecondary data analysisCross-sectional studyRevision of diagnostic criteriaSymptom-based definitionsDSM criteriaStress disorderSymptom heterogeneityDisorder presentationsClinical populationsMain OutcomesAssess symptomsGroup of individualsParticipantsSymptomsNational InstituteDisordersIndividualsSchizophreniaAnxietyIndividual frequencies
2025
Dissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures
Ben-Zion Z, Basol E, Simon A, Abargil M, Samonek K, Patterson M, Spiller T, Duek O, Just S, Preller K, Keynan J, Admon R, Liberzon I, Shalev A, Hendler T, Levy I, Joormann J, Scheinost D, Harpaz-Rotem I. Dissecting Fear and Emotional Pain in PTSD: From Symptom Networks to Neural Signatures. Biological Psychiatry 2025 PMID: 41319905, DOI: 10.1016/j.biopsych.2025.11.016.Peer-Reviewed Original ResearchAltmetricConceptsPosttraumatic stress disorderConnectome-based predictive modelingEmotional painSymptom networksNeural signaturesSymptom severityStudy 1PTSD dimensionsPosttraumatic Stress Disorder ChecklistPosttraumatic stress disorder symptomsSubjective ratingsTrauma-exposed individualsTrauma-related psychopathologyDiverse symptom presentationsPost-traumaRatings of fearMechanism-based interventionsCentral executiveEmotional reactivityDSM-5PCL-5Distressing memoriesStress disorderDefault-modeCentral symptomsUnraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment
Gross G, Spiller T, Ben-Zion Z, Rubenstein A, Pietrzak R, Duek O, Hoff R, Harpaz-Rotem I. Unraveling PTSD: Symptom Cluster Change During and 1 Year After Veterans’ Residential PTSD Treatment. Psychological Trauma Theory Research Practice And Policy 2025, 17: 1780-1788. PMID: 38990694, DOI: 10.1037/tra0001734.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPosttraumatic stress disorderPosttraumatic stress disorder symptom clustersPosttraumatic stress disorder clustersSymptom clustersIntrusive symptomsResidential treatmentTreatment of posttraumatic stress disorderPosttraumatic stress disorder symptomsResidential PTSD treatmentPTSD symptom clustersNovel treatment interventionsDifferential treatment responseReduce symptom severityDifferential patterns of changeAvoidance symptomsPTSD treatmentTreatment gainsStress disorderVeterans AffairsSymptom severityCluster CTreatment interventionsCluster BIndividual symptomsCohort of veteransPosttraumatic Stress Symptoms, Functioning, and Suicidal Ideation in Older U.S. Veterans: A Network Analysis
Pietrzak R, Fischer I, Na P, Cook J, Spiller T. Posttraumatic Stress Symptoms, Functioning, and Suicidal Ideation in Older U.S. Veterans: A Network Analysis. American Journal Of Geriatric Psychiatry 2025, 34: 106-112. PMID: 41111050, DOI: 10.1016/j.jagp.2025.09.018.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPosttraumatic stress disorderSubthreshold posttraumatic stress disorderPosttraumatic stress disorder symptomsSuicidal ideationFunctional difficultiesNational Health and ResiliencePosttraumatic stress symptomsOlder U.S. veteransU.S. military veteransAssociated with functional difficultiesAnhedonic symptomsSymptom centralityPTSD symptomsPhysiological reactivityStress disorderVeterans StudySuicide riskStress symptomsMilitary veteransNegative beliefsU.S. veteransOlder veteransVeteransDual-focus approachIdeationEvaluating the potential of the outcome-oriented nursing assessment for acute care (ePA–AC) to identify cardiovascular patients at risk for unplanned 30- and 180-day all-cause readmission: Development and validation of a routine data-based model
Schmid-Mohler G, Spiller T, Jumuga T, Held U, Cincera A, Petry H, Ernst J, Hermann M. Evaluating the potential of the outcome-oriented nursing assessment for acute care (ePA–AC) to identify cardiovascular patients at risk for unplanned 30- and 180-day all-cause readmission: Development and validation of a routine data-based model. American Heart Journal Plus Cardiology Research And Practice 2025, 59: 100615. PMID: 41035500, PMCID: PMC12481098, DOI: 10.1016/j.ahjo.2025.100615.Peer-Reviewed Original ResearchConceptsNursing assessmentEmergency department visitsRisk factorsRegression modelsDays post-dischargeBreathing problemsLogistic regression modelsNursing dataAcute careDepartment visitsRetrospective cohort studyRoutine dataCardiovascular inpatientsCox proportional hazards regression analysisInpatient dataMultiple Cox proportional hazards regression analysisProportional hazards regression analysisPost-dischargeCox regression modelsCohort studyHazards regression analysisChronic painLogistic regressionRehospitalisation ratesRehospitalisationA Network Analysis of Psychosocial Functioning and Posttraumatic Stress Disorder and Depression Symptoms in a Nationally Representative U.S. Veteran Cohort
Hallenbeck H, Spiller T, Kuhn E, Cloitre M, Pietrzak R. A Network Analysis of Psychosocial Functioning and Posttraumatic Stress Disorder and Depression Symptoms in a Nationally Representative U.S. Veteran Cohort. Psychological Trauma Theory Research Practice And Policy 2025 PMID: 40773343, DOI: 10.1037/tra0002002.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPsychosocial functional impairmentStress disorderPsychosocial functioningDepressive symptomsNational Health and ResilienceTrauma-exposed veteransIntensive longitudinal dataPotential targets of interventionTargeting of interventionsSuicidal ideationVeterans StudyU.S. veteransDepressionFunctional impairmentVeteransDisordersVeteran cohortImpairmentGaussian graphical modelsSymptomsLongitudinal dataCross-sectional dataIrritability/angerIdeationCrisis versus extended care: bimodal distribution of length of stay in psychiatric inpatients
Hofmann A, Spiller T, Rapaport J, Homan P, Seifritz E, Vetter S, Egger S, Burrer A. Crisis versus extended care: bimodal distribution of length of stay in psychiatric inpatients. BMC Psychiatry 2025, 25: 711. PMID: 40676565, PMCID: PMC12273316, DOI: 10.1186/s12888-025-07149-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDiagnostic categoriesCrisis interventionSchizophrenia spectrum disordersOrganic mental disordersShort-term crisis interventionStress-related disordersPsychiatric care systemICD-10 classificationBackgroundThe length of stayPsychiatric inpatientsDepressive disorderDiagnostic boundariesBipolar disorderHoNOS scoresPsychiatric settingsMental disordersPsychiatric hospitalLong-stay patientsSpectrum disorderDiagnostic groupsPsychiatric facilitiesICD-10Short-stay patientsDisordersTreatment approaches28. "Taking Chat-GPT to Therapy": Assessing and Alleviating State Anxiety in Large Language Models
Ben-Zion Z, Witte K, Jagadish A, Duek O, Harpaz-Rotem I, Khorsandian M, Burrer A, Seifritz E, Homan P, Schulz E, Spiller T. 28. "Taking Chat-GPT to Therapy": Assessing and Alleviating State Anxiety in Large Language Models. Biological Psychiatry 2025, 97: s106-s107. DOI: 10.1016/j.biopsych.2025.02.265.Peer-Reviewed Original ResearchPsychiatric treatment outcomes of travelers admitted to a psychiatric hospital: a retrospective analysis
Burrer A, Spiller T, Koussemou J, Schoretsanitis G, Homan P, Weidt S, Seifritz E, Vetter S, Egger S. Psychiatric treatment outcomes of travelers admitted to a psychiatric hospital: a retrospective analysis. Tropical Diseases, Travel Medicine And Vaccines 2025, 11: 9. PMID: 40301998, PMCID: PMC12042500, DOI: 10.1186/s40794-024-00244-x.Peer-Reviewed Original ResearchCitationsConceptsOutcome of psychiatric treatmentPsychiatric University Hospital ZurichCGI-I scorePsychiatric treatment outcomesAnxiety disordersMood disordersPsychiatric disordersPsychiatric treatmentPsychiatric hospitalSubstance abuseSymptom improvementTreatment responseDisordersTreatment outcomesInitial treatment responseOutcome of treatmentSwiss nationalsPsychosisElectronic health recordsPsychiatricMoodAnxietyAbuseExploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial
Omlor W, Cecere G, Huang G, Spiller T, Misra A, Rabe F, Kallen N, Kirschner M, Surbeck W, Burrer A, Garibaldi G, Holiga Š, Dukart J, Umbricht D, Homan P. Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial. BMC Medicine 2025, 23: 187. PMID: 40155941, PMCID: PMC11951735, DOI: 10.1186/s12916-025-04004-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAnterior cingulate regionsStriatal connectivityNegative symptomsApathy dimensionsCingulate regionsAdd-on to antipsychoticsDimensions of negative symptomsResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingNegative symptom dimensionsCortico-striatal circuitsAnterior cingulate cortexCortico-striatal connectivityAssociated with apathyExploratory analysisBackgroundNegative symptomsComputing rank correlationsPost hoc exploratory analysisAntipsychotic medicationSymptom dimensionsNeurobiological correlatesCingulate cortexExpressive deficitsParacingulate gyrusAdministration of placebo
Academic Achievements & Community Involvement
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Activities
activity European Journal of Psychotraumatology
2023 - PresentJournal ServiceEditorial Board Memberactivity Zurich
08/01/2019 - 04/30/2021ResearchDetailsZürich, ZH, Switzerlandactivity Junior Visiting Research Fellow
04/01/2016 - 06/30/2016ResearchDetailsSydney, NSW, Australia
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