Sven-Eric Jordt, PhD
Associate Professor of Anesthesiology, Pharmacology & Cancer Biology, University Program of Environmental Health (UPEH), Duke University School of MedicineAbout
Research
Publications
2024
Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Jordt S, Gentile M, Albert C, Schulte K, Pantazides B, Crow B, Quiñones-González J, Perez J, Ford D, Patel R, Blake T, Gunn M, Achanta S. Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury. 2024, pa5302. DOI: 10.1183/13993003.congress-2024.pa5302.Peer-Reviewed Original ResearchSynthetic cooling agents and nicotine analogs in new tobacco products: tobacco industry strategies to bypass regulation
Jordt S, Erythropel H, Silinski P, Zimmerman J, Anastas P, Jabba S. Synthetic cooling agents and nicotine analogs in new tobacco products: tobacco industry strategies to bypass regulation. 2024, pa4038. DOI: 10.1183/13993003.congress-2024.pa4038.Peer-Reviewed Original ResearchVariability in Constituents of E-Cigarette Products Containing Nicotine Analogues
Erythropel H, Jabba S, Silinski P, Anastas P, Krishnan-Sarin S, Zimmerman J, Jordt S. Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues. JAMA 2024, 332: 753-755. PMID: 39110443, PMCID: PMC11307159, DOI: 10.1001/jama.2024.12408.Peer-Reviewed Original ResearchMarketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco
Jabba S, Jordt S. Marketing of nicotinamide as nicotine replacement in electronic cigarettes and smokeless tobacco. Tobacco Prevention & Cessation 2024, 10: 1-5. PMID: 39132445, PMCID: PMC11295357, DOI: 10.18332/tpc/187767.Peer-Reviewed Original ResearchAn Electronic Cigarette Pod System Delivering 6-methyl Nicotine, A Synthetic Nicotine Analog, Marketed in the United States as "PMTA Exempt"
Jordt S, Silinski P, Berman M. An Electronic Cigarette Pod System Delivering 6-methyl Nicotine, A Synthetic Nicotine Analog, Marketed in the United States as "PMTA Exempt". 2024, a2135-a2135. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2135.Peer-Reviewed Original ResearchSpree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as ‘PMTA exempt’
Jordt S, Jabba S, Zettler P, Berman M. Spree Bar, a vaping system delivering a synthetic nicotine analogue, marketed in the USA as ‘PMTA exempt’. Tobacco Control 2024, tc-2023-058469. PMID: 38499343, PMCID: PMC11408701, DOI: 10.1136/tc-2023-058469.Peer-Reviewed Original ResearchVagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice
Wu P, Caceres A, Chen J, Sokoloff J, Huang M, Baht G, Nackley A, Jordt S, Terrando N. Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice. Pain 2024, 165: e80-e92. PMID: 38422485, PMCID: PMC11247455, DOI: 10.1097/j.pain.0000000000003181.Peer-Reviewed Original ResearchDorsal root gangliaPostoperative painVagus nerve stimulationPain behaviorOrthopedic surgeryNerve stimulationHindpaw mechanical allodyniaPrevent postoperative painFemale C57BL/6J miceOrthopedic trauma surgeryMechanical allodyniaAntinociceptive effectPersistent painAccelerated bone healingAnalgesic effectAdult miceC57BL/6J miceEffective therapyNeuropeptide levelsSpinal cordMouse modelSatellite cellsSurgeryPainVagus nerveRecapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury
Achanta S, Gentile M, Albert C, Schulte K, Pantazides B, Crow B, Quiñones-González J, Perez J, Ford D, Patel R, Blake T, Gunn M, Jordt S. Recapitulation of human pathophysiology and identification of forensic biomarkers in a translational model of chlorine inhalation injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 326: l482-l495. PMID: 38318664, PMCID: PMC11281795, DOI: 10.1152/ajplung.00162.2023.Peer-Reviewed Original ResearchAcute lung injuryBronchoalveolar lavage fluidChlorine gasChlorinated fatty acidsDecreased dynamic lung complianceHuman acute lung injuryPeak inspiratory pressureIncreased airway resistanceMedical countermeasuresControlled mechanical ventilationForensic biomarkersDynamic lung complianceFormation of microthrombiProtein adductsAir-exposed groupNeutrophilic alveolitisTesting medical countermeasuresVascular leakageNeutrophil countPulmonary edemaHistopathological featuresPotential medical countermeasuresForensic analysisInspiratory pressureLung injury
2023
Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries
Achanta S, Chintagari N, Balakrishna S, Liu B, Jordt S. Pharmacologic inhibition of TRPA1 counteract tear gas induced cutaneous injuries. Journal Of Pharmacology And Experimental Therapeutics 2023, 388: jpet-ar-2023-001666. PMID: 38050077, PMCID: PMC10801748, DOI: 10.1124/jpet.123.001666.Peer-Reviewed Original ResearchTransient receptor potential ankyrin 1Tear gas agentsCutaneous injurySkin injuryTRPA1 antagonistTRPA1 inhibitor HC-030031Injury parametersWeek old C57BL/6 male miceInflammatory cytokine levelsC57BL/6 male miceTherapeutic efficacy studiesEffects of CSNeuronal ion channelsMouse ear skinTRPA1 inhibitionAirway obstructionNeurogenic inflammationCytokine levelsHC-030031Severe painPlasma extravasationCS exposureAcute irritationAcute toxic effectsFrequent injuriesTransient Receptor Potential channels (TRP) in GtoPdb v.2023.3
Blair N, Caceres A, Carvacho I, Chaudhuri D, Clapham D, De Clerq K, Delling M, Doerner J, Fan L, Grimm C, Ha K, Hu M, Jabba S, Jordt S, Julius D, Kahle K, Liu B, Liu Q, McKemy D, Nilius B, Oancea E, Owsianik G, Riccio A, Sah R, Stotz S, Tian J, Tong D, Vriens J, Wu L, Xu H, Yang F, Yang W, Yue L, Zhu M. Transient Receptor Potential channels (TRP) in GtoPdb v.2023.3. IUPHAR/BPS Guide To Pharmacology CITE 2023, 2023 DOI: 10.2218/gtopdb/f78/2023.3.Peer-Reviewed Original ResearchTRPC channelsTransient receptor potential channelsCongenital stationary night blindnessCalcium-activated cationStore-operated channelsAdenosine diphosphate riboseNumerous splice variantsNMDA receptorsActivate TRPA1Cation channelsIntracellular ATP levelsChannel activityMicromolar concentrations of La3+Neurodegenerative disorder mucolipidosis type IVDepletion of intracellular calcium storesMucolipidosis type IVTRP channelsRegulation of Ca2+ entryAssociated with conduction defectsDetection of noxious heatDevelopment of heat hyperalgesiaDevelopment of thermal hyperalgesiaDynamic intracellular vesicular structuresExtra-synaptic NMDA receptorsInvolvement of TRP channels
Academic Achievements & Community Involvement
News
News
- August 07, 2024
Novel E-Cigarette Products Marketed to Contain Nicotine Analogs Instead of Nicotine Show Discrepancies Between Label Information and Contents
- June 03, 2024Source: Scientific American
How Tobacco Companies Use Chemistry To Get Around Menthol Bans
- September 27, 2023
$20M Federal Grant Renewed for Yale Tobacco Center of Regulatory Science
- March 08, 2022Source: The New York Times
The Loophole That’s Fueling a Return to Teenage Vaping