Kirsha Gordon, PhD, MS
Research ScientistCards
About
Research
Publications
2026
The Association of Neurocognitive Symptoms With Opioid Overdose Events Among Patients on Long-Term Opioid Therapy.
León C, Sung M, Reisman J, Liu W, Kerns R, Gordon K, Mitra A, Kwon S, Yu H, Becker W, Li W. The Association of Neurocognitive Symptoms With Opioid Overdose Events Among Patients on Long-Term Opioid Therapy. Substance Use & Addiction Journal 2026, 29767342261443858. PMID: 42157377, DOI: 10.1177/29767342261443858.Peer-Reviewed Original ResearchLong-term opioid therapyNeurocognitive symptomsOpioid therapyOpioid overdoseVeterans Health AdministrationSubstance use disordersMorphine equivalent daily doseOverdose riskAssociated with opioid overdoseVHA visitEquivalent daily doseCox regression analysisRetrospective cohort studyLong-term opioid therapy episodesCox proportional hazards modelsChronic obstructive pulmonary diseaseRisk of opioid overdoseChronic kidney diseaseUse disorderObstructive pulmonary diseaseProportional hazards modelCognitive impairmentNational Veterans Health AdministrationNonfatal opioid overdoseOpioid overdose riskImpact of SARS-CoV-2 Breakthrough Infection on Short-Term CD4 Count Among Adults With HIV in the United States From 2020 to 2022
Hopkins L, Humes E, Gordon K, Marconi V, Lang R, Horberg M, Napravnik S, Silverberg M, Browne L, Park L, Gebo K, Agil D, Althoff K, Coburn S. Impact of SARS-CoV-2 Breakthrough Infection on Short-Term CD4 Count Among Adults With HIV in the United States From 2020 to 2022. Open Forum Infectious Diseases 2026, 13: ofag284. PMID: 42221370, PMCID: PMC13221637, DOI: 10.1093/ofid/ofag284.Peer-Reviewed Original ResearchSARS-CoV-2 breakthrough infectionsCD4 countCOVID-19 breakthrough infectionsBreakthrough infectionViral clearanceSARS-CoV-2Undetectable HIV viral loadHIV viral loadCD4 T cellsClearance of SARS-CoV-2Effects of SARS-CoV-2Years of ageT cellsViral loadCD4Statistically significant changesPWHDisease severityHIVInfectionSignificant changesMixed effects modelsLinear mixed effects modelsCountSeverityThe association between long-term opioid therapy and composite infection-related dental outcomes
Black A, Gordon K, Dziura J, Barry D, Crystal S, Edelman E, Gibson G, Hamilton M, Jurasic M, Li Y, Marshall B, Skanderson M, Suda K, Becker W. The association between long-term opioid therapy and composite infection-related dental outcomes. PLOS ONE 2026, 21: e0341361. PMID: 41628103, PMCID: PMC12863492, DOI: 10.1371/journal.pone.0341361.Peer-Reviewed Original ResearchConceptsFood and Drug AdministrationDental coverageDental outcomesLong-term opioid therapyComprehensive dental coveragePartial opioid agonistFollow-up timeCox regression modelsOpioid use disorderAssociated with riskNational cohort studyPatient-provider discussionsOpioid therapyOpioid agonistsOpioid analgesicsChronic painDental diseaseMultivariate regression modelCohort studyDrug AdministrationPatientsUse disorderRegression modelsUnclear generalizabilityResidual confoundingAppropriate Clinical Response Following Opioid Overdose: A Retrospective Analysis Within the Veterans Health Administration System.
Kazemitabar M, Reisman J, Sung M, Kerns R, Druhl E, Yu H, Li W, Becker W, Gordon K. Appropriate Clinical Response Following Opioid Overdose: A Retrospective Analysis Within the Veterans Health Administration System. Journal Of Addiction Medicine 2026 PMID: 41521434, DOI: 10.1097/adm.0000000000001644.Peer-Reviewed Original ResearchOpioid use disorderSubstance use disordersUse disorderVeterans Health Administration systemHealth Administration systemClinical responseCare accessSocial determinantsOpioid overdoseDose reductionSocial determinants of healthBipolar disorderAdjusted modelsDeterminants of healthMorphine equivalent daily doseElectronic health recordsInitiation of medicationOpioid dose reductionNonfatal opioid overdoseInitiation of MOUDEquivalent daily doseRetrospective cohort studyBinary logistic regression modelWhite veteransLogistic regression models
2025
Concurrent Alcohol Use and the Relative Risk of Community‐Acquired Pneumonia Associated With Anticholinergic and Non‐Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case–Control Study Among US Veterans
Wang W, Crothers K, Akgün K, Gordon K, Rodriguez‐Barradas M, Womack J, Thompson J, Justice A, Rentsch C. Concurrent Alcohol Use and the Relative Risk of Community‐Acquired Pneumonia Associated With Anticholinergic and Non‐Anticholinergic Neurocognitively Active Medication Receipt: A National Nested Case–Control Study Among US Veterans. Pharmacoepidemiology And Drug Safety 2025, 34: e70279. PMID: 41340437, PMCID: PMC12676203, DOI: 10.1002/pds.70279.Peer-Reviewed Original ResearchConceptsNested Case-Control StudyConcurrent alcohol useOdds ratioCase-control studyAlcohol useRelative riskCommunity-acquired pneumoniaAt-risk consumptionRisk of community-acquired pneumoniaIncident CaP casesCohort entry dateActive medicationMedication receiptUS veteransSelf-report measuresMedication usePrimary exposureAlcohol consumptionConsuming alcoholHospital admissionCohort studyMedication typeIndex dateLogistic regressionIncidence densityLong-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study
Macmadu A, Li Y, Bhondoekhan F, Chang C, Bahji A, Crystal S, Gordon K, Kerns R, Vickers-Smith R, Edelman E, Marshall B. Long-term, bidirectional associations between depressive symptom severity and opioid use among people with HIV: A prospective cohort study. Addictive Behaviors Reports 2025, 22: 100619. PMID: 40547483, PMCID: PMC12182372, DOI: 10.1016/j.abrep.2025.100619.Peer-Reviewed Original ResearchDepressive symptom severityVeterans Aging Cohort StudySymptom severityOpioid useCohort studySubstance use disordersPrescription opioid useProspective cohort studyOpioid use disorderAging Cohort StudyMental health servicesDose-response patternGeneralized Estimating Equation modelsVeterans Health Administration sitesUse disorderClinical characteristicsProspective cohortBidirectional associationsFollow-upStudy entryOpioidHarm reduction servicesBidirectional relationshipPLHIVAdministration siteCannabis Use and Self-Reported Bothersome Symptoms in People with HIV
Wrona A, Justice A, Tate J, Rentsch C, Gordon K, Kidwai-Khan F, Silverberg M, Satre D, Marconi V, Ingle S, Sterne J, Cavassini M, Bryant K, McGinnis K. Cannabis Use and Self-Reported Bothersome Symptoms in People with HIV. Cannabis 2025, 8: 177-190. PMID: 39968492, PMCID: PMC11831903, DOI: 10.26828/cannabis/2025/000269.Peer-Reviewed Original ResearchCannabis useKaiser Permanente Northern CaliforniaSwiss HIV Cohort StudyHIV Symptom IndexSelf-ReportBothersome symptomsSubstance useAssociations of self-reportedBothersome levelSelf-reported substanceMental health symptomsSymptom IndexSelf-reported informationHIV Cohort StudyPatterns of associationWeight lossPresence/absence of symptomsCross-cohort studyLogistic regression modelsHealth symptomsCannabisHealth outcomesLoss of appetiteHIV cohortStudy HIVLGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters
Workman T, Goulet J, Brandt C, Skanderson M, O’Leary J, Gordon K, Treitler-Zeng Q. LGBTQ+ status and sex of record in Veterans with post-traumatic stress disorder: demographics, comorbidities, and outpatient encounters. Frontiers In Public Health 2025, 12: 1487866. PMID: 39835315, PMCID: PMC11743380, DOI: 10.3389/fpubh.2024.1487866.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaLGBTQ+ individualsMedical care usagePost-traumatic stress disorderTransgenderSexual traumaMarital statusSubstance use disorder diagnosisMental healthStress disorderContext of post-traumatic stress disorderQueerLGBTQ+CrimeVeterans with post-traumatic stress disorderMaltreatmentVeteransOutpatient encountersPolicySexStatusIncreased riskDemographicsChi-squareDisorder diagnosis
2024
Effectiveness of dolutegravir-based regimens compared to raltegravir-, elvitegravir-, bictegravir, and darunavir-based regimens among older adults with HIV in the Veterans Aging Cohort Study (VACS)
Yan L, Henegar C, Marconi V, Gordon K, Hicks C, Vannappagari V, Justice A, Aslan M. Effectiveness of dolutegravir-based regimens compared to raltegravir-, elvitegravir-, bictegravir, and darunavir-based regimens among older adults with HIV in the Veterans Aging Cohort Study (VACS). AIDS Research And Therapy 2024, 21: 96. PMID: 39709467, PMCID: PMC11662819, DOI: 10.1186/s12981-024-00681-w.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmidesAnti-HIV AgentsCohort StudiesDarunavirDrug Therapy, CombinationFemaleHeterocyclic Compounds, 3-RingHeterocyclic Compounds, 4 or More RingsHIV InfectionsHIV Integrase InhibitorsHumansMaleMiddle AgedOxazinesPiperazinesPyridazinesPyridonesQuinolonesRaltegravir PotassiumTreatment OutcomeVeteransViral LoadConceptsVeterans Aging Cohort StudyRAL-based regimenAntiretroviral therapyAging Cohort StudyCohort studyOdds of virologic suppressionIntegrase strand transfer inhibitorsDarunavir-based regimensDolutegravir-based regimensDTG-based regimensAntiretroviral therapy experienceHuman immunodeficiency virusDTG-based regimenInverse probability of treatment weightingStrand transfer inhibitorsBackgroundReal-world dataProbability of treatment weightingMethodsThis cohort studyVirologic suppressionVirological failureVirological effectImmunodeficiency virusDarunavir/ritonavirClinical outcomesRegimen initiationOccurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy
León C, Sung M, Reisman J, Liu W, Kerns R, Gordon K, Mitra A, Kwon S, Yu H, Becker W, Li W. Occurrence of Opioid-Related Neurocognitive Symptoms Associated With Long-term Opioid Therapy. The Clinical Journal Of Pain 2024, 41: e1266. PMID: 39682036, PMCID: PMC11729567, DOI: 10.1097/ajp.0000000000001266.Peer-Reviewed Original ResearchLong-term opioid therapyElectronic health recordsIncidence rate ratiosOpioid-related harmsSubstance use disordersNeurocognitive symptomsHazard ratioPatients prescribed long-term opioid therapyVeterans Health AdministrationCalculated incidence ratesAssociated with increased likelihoodChronic obstructive pulmonary diseasePost-traumatic stress disorderHealth recordsProportional hazards modelRetrospective cohort studyObstructive pulmonary diseaseHealth AdministrationRate ratiosIncidence rateCohort studyTraumatic brain injuryClinical notesExtract dataHazards model