Inderjit Singh, MBChB, BMedSci, FRCP, FCCP, MD
Associate Professor TermCards
About
Research
Publications
2026
Beyond PVR: dynamic physiologic assessment enhances prognostic evaluation in pulmonary hypertension associated with chronic obstructive pulmonary disease
Tarras E, Yan X, Gange C, Kurz S, Joseph P, Singh I. Beyond PVR: dynamic physiologic assessment enhances prognostic evaluation in pulmonary hypertension associated with chronic obstructive pulmonary disease. BMJ Open Respiratory Research 2026, 13: e004192. PMID: 42303310, PMCID: PMC13289187, DOI: 10.1136/bmjresp-2026-004192.Peer-Reviewed Original ResearchConceptsPulmonary vascular resistanceAssociated with adverse outcomesRight heart catheterisationPH-COPDChronic obstructive pulmonary diseaseObstructive pulmonary diseaseHeart catheterisationResting haemodynamicsML/mm HgAdverse outcomesOxygen uptake efficiency slopeRight ventricular systolic pressurePulmonary diseaseExercise test variablesCardiopulmonary exercise testing variablesHighest-risk subgroupsAssociated with poor outcomesMedian Follow-UpPulmonary function test parametersVentricular systolic pressureHeart failure hospitalisationPulmonary vascular capacitanceLower oxygen uptake efficiency slopeSurvival tree analysisCox proportional hazards modelsStiff Left Atrial Syndrome: Hemodynamic Insights and a Noninvasive Diagnostic Approach
Haghani Rad N, Okasha O, Kwan J, Heerdt P, Singh I. Stiff Left Atrial Syndrome: Hemodynamic Insights and a Noninvasive Diagnostic Approach. Annals Of The American Thoracic Society 2026, aaoag163. PMID: 42295833, DOI: 10.1093/annalsats/aaoag163.Peer-Reviewed Original ResearchRight Ventricular End‐Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Tarras E, Arun A, Joseph P, Heerdt P, Singh I. Right Ventricular End‐Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. Comprehensive Physiology 2026, 16: e70187. PMID: 42210677, DOI: 10.1002/cph4.70187.Peer-Reviewed Original ResearchConceptsArea under the receiver operating characteristic curveAssociated with mortalityPH-HFpEFRV pressureEjection fractionRetrospective studyHeart failureRight ventricular (RV) dysfunctionHemodynamic indicesPH-HFpEF patientsPulmonic valve closureRV pressure waveformsAssociated with all-cause mortalityAssociated with heart failurePreserved Ejection FractionKaplan-Meier analysisMultivariate Cox analysisDetermination of prognosisCox proportional hazards modelsReceiver operating characteristic curveAll-Cause MortalityLASSO-penalized logistic regressionCross-validated area under the receiver operating characteristic curveOperating characteristics curveProportional hazards modelComparative Pulmonary Artery Pressure Response between Large-Bore Thrombectomy and Catheter-Directed Thrombolysis in Patients with Intermediate-High- and High-Risk Pulmonary Embolism
Conte M, Khosla A, Singh I, Hur J, Pollak J, Mojibian H, Marino A, Heerdt P, Cornman-Homonoff J. Comparative Pulmonary Artery Pressure Response between Large-Bore Thrombectomy and Catheter-Directed Thrombolysis in Patients with Intermediate-High- and High-Risk Pulmonary Embolism. Journal Of Vascular And Interventional Radiology 2026, 37: 108863. PMID: 42177020, DOI: 10.1016/j.jvir.2026.108863.Peer-Reviewed Original ResearchChronic thromboembolic pulmonary hypertensionCatheter-directed thrombolysisPulmonary artery pressurePE-related outcomesHigh-risk pulmonary embolismPulmonary embolismAdverse eventsCatheter-directed thrombolysis groupMean body mass indexPulmonary artery pressure responseIntermediate-highThromboembolic pulmonary hypertensionPE-related mortalityPE-related deathPeriprocedural adverse eventsCatheter-based therapiesPeriprocedural complication rateRight atrial pressureBody mass indexHemodynamic responseArterial pressure responseAssociated with greater oddsPE recurrencePropensity score matchingPulmonary hypertensionReply to Sbarra et al.
Oakland H, Heerdt P, Hunter K, Singh I. Reply to Sbarra et al. AJP Heart And Circulatory Physiology 2026, 330: h1711-h1712. PMID: 42065598, DOI: 10.1152/ajpheart.00243.2026.Commentaries, Editorials and LettersC65-17 Noninvasive Predictors of Adverse Outcomes in Pulmonary Hypertension Associated With COPD
Tarras E, Yan X, Kurz S, Gange C, Singh I. C65-17 Noninvasive Predictors of Adverse Outcomes in Pulmonary Hypertension Associated With COPD. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.5846. DOI: 10.1093/ajrccm/aamag162.5846.Peer-Reviewed Original ResearchPulmonary vascular resistancePulmonary hypertensionPH-COPDAssociated with COPDNoninvasive predictorAdverse outcomesPre-capillary pulmonary hypertensionNoninvasive indexPredictor of adverse outcomesAssociated with adverse outcomesImpaired qualityObstructive sleep apneaRight heart catheterizationPulmonary function test parametersHigh-risk patientsAdverse clinical outcomesCox proportional hazards modelsCardiopulmonary exercise testingFunction test parametersImpaired quality of lifeSevere PH-COPDProportional hazards modelCombined post-Sleep apneaHeart catheterizationA28-22 Association of Coronary Vasomotor Disorders and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome in Patients Undergoing Invasive Cardiopulmonary Exercise Testing
Mackay Z, Shah S, Joseph P, Heerdt P, Singh I. A28-22 Association of Coronary Vasomotor Disorders and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome in Patients Undergoing Invasive Cardiopulmonary Exercise Testing. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.1316. DOI: 10.1093/ajrccm/aamag162.1316.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingCoronary function testingCoronary microvascular dysfunctionCoronary vasomotor disordersCardiopulmonary exercise testingCoronary flow reserveVasomotor disordersEndothelial dysfunctionMyalgic encephalomyelitis/chronic fatigue syndromePET-CTChest painCoronary vasospasmInvasive coronary function testingCoronary vasomotor abnormalitiesExercise testObstructive atherosclerotic coronary artery diseaseArterial-venous oxygen content differenceInvasive coronary angiographyMixed venous oxygen saturationACh provocation testAtherosclerotic coronary artery diseaseAssessment of coronary flow reserveCoronary microvascular diseasePersistent inflammatory stateVenous oxygen saturationC64-06 Right Ventricular End-Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction
Tarras E, Arun A, Heerdt P, Singh I. C64-06 Right Ventricular End-Ejection Pressure Predicts Mortality in Patients With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction. American Journal Of Respiratory And Critical Care Medicine 2026, 212: aamag162.1568. DOI: 10.1093/ajrccm/aamag162.1568.Peer-Reviewed Original ResearchPulmonic valve closurePulmonary vascular resistancePredictors of mortalityPulmonary arterial compliancePH-HFpEFHemodynamic predictorsNT-proBNPCpc-PHPulmonary hypertensionEjection fractionIpc-PHRV pressureHeart failureAtrial pressureRight ventricular (RV) afterloadMean pulmonary artery pressureCox modelCpc-PH patientsHigher NT-proBNPPH-HFpEF patientsRV pressure waveformsAssociated with heart failureRight heart catheterizationElevating left atrial pressureLow cardiac outputPre-capillary Pulmonary Hypertension in a Patient with Interlobular Septal Thickening and Prominent Mediastinal Lymphadenopathy
Tarras E, Homer R, Singh I. Pre-capillary Pulmonary Hypertension in a Patient with Interlobular Septal Thickening and Prominent Mediastinal Lymphadenopathy. Annals Of The American Thoracic Society 2026, aaoag099. PMID: 42011712, DOI: 10.1093/annalsats/aaoag099.Peer-Reviewed Original ResearchSkin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis
Zielonka J, Li N, Liu Y, Yan X, Wang Z, Ramirez M, Figueroa A, Korde A, Yin H, Britto C, Singh I, Sun H, Herzog E, Feghali‐Bostwick C, Hinchcliff M, Ryu C, Gomez J. Skin Transcriptomics Reveal Shared Molecular Mechanisms for Skin and Lung Involvement in Systemic Sclerosis. Arthritis & Rheumatology 2026 PMID: 41930625, DOI: 10.1002/art.70163.Peer-Reviewed Original ResearchSSc-ILDSystemic sclerosisStromal cellsMultiorgan involvementSSc-related interstitial lung diseaseKRAS pathwaySevere multiorgan involvementSystemic sclerosis skinInterstitial lung diseaseCutaneous signaturesLung involvementDysregulated immunityCause of deathGene Set Enrichment AnalysisImmune cellsProgressive fibrosisSkin fibrosisLung fibrosisSingle-cell RNA sequencingLung diseaseMicrovascular damageLung impairmentLung functionGene correlation analysisKRAS
Academic Achievements & Community Involvement
Clinical Care
Overview
Inderjit Singh, MBChB, (a medical degree awarded in the United Kingdom) is director of the Pulmonary Vascular Disease Program and specializes in treating pulmonary hypertension (high blood pressure in the heart-to-lung system).
Dr. Singh was steered toward medicine at an early age while growing up in Malaysia, where his father was a pediatrician. He often accompanied his father to work and says he enjoyed watching him help others feel better.
During medical school, he was drawn to pulmonary medicine, within which he discovered pulmonary vascular medicine—and pulmonary hypertension in particular.
“I have a strong interest in understanding the right heart and how it interacts with the pulmonary circulation,” Dr. Singh says. “And I like how pulmonary hypertension overlaps with so many specialties from cardiology to rheumatology to hepatology. You need to know all the different organs and disease processes to understand pulmonary hypertension.”
Pulmonary hypertension is also an exciting field because of many advancements in treatment, he says. “For a long time, we didn’t have much to offer in terms of therapy. But now there is more understanding of the disease, so much so that now you have dedicated training programs for pulmonary hypertension,” he says.
For research, Dr. Singh explores how the right ventricle of the heart and the pulmonary circulation interact, particularly during exercise.
“Our research is mainly focused on how the right heart interacts with the lungs’ blood vessels at rest and during exercise,” he explains. “We are one of the few centers in the world that performs invasive cardiopulmonary exercise test (iCPET). We primarily perform iCPET for patients who have unexplained shortness of breath or fatigue. So, these are patients who've had all the routine investigative testing, all of which do not explain their symptoms.”
Clinical Specialties
Pulmonary Hypertension; Pulmonary Critical Care
Fact Sheets
Pulmonary Hypertension
Learn More on Yale MedicinePulmonary Embolism
Learn More on Yale MedicineAcute Respiratory Distress Syndrome (ARDS)
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Yale Medicine News
News
News
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- July 24, 2024
Yale Department of Internal Medicine Faculty Promotions and Appointments (July 2024)
- April 27, 2023
Study Uncovers Reduced Exercise Tolerance and Other Changes in Long COVID
- February 21, 2022
Despite Recovering from COVID-19, Shortness of Breath Persists
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Pulmonary Vascular Disease Program
15 York Street, Lippard Laboratory for Clinical Investigation
NEW HAVEN, CT 06519
United States
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