Declan McGuone, FRCPath Neuro, MBBCh
Associate Professor of PathologyCards
About
Research
Publications
2026
Forensic and neuropathological characteristics of lethal acute blunt traumatic spinal cord injury
Wachtler N, Roman K, Stuelpnagel J, Landi K, Storck K, Booth C, Faust B, Leelatian N, McGuone D. Forensic and neuropathological characteristics of lethal acute blunt traumatic spinal cord injury. Journal Of Forensic Sciences 2026 PMID: 41803054, DOI: 10.1111/1556-4029.70305.Peer-Reviewed Original ResearchTraumatic spinal cord injuryAcute traumatic spinal cord injuryMotor vehicle collisionsSpinal cord injuryCord injurySpinal injuryVehicle collisionsTrauma mechanismMechanism of injuryClinical registryAtlanto-axial dislocationInclusion criteriaStanding heightNew York City OfficeTrauma dataAcute spinal cord injuryMedical examinationSpinal diseaseChief Medical ExaminerPrevent neurological disordersYoung individualsAutopsy dataNeuropathological dataExtra-axial hemorrhageAutopsy records
2025
Subgroup of meningiomas involving FOS and FOSB gene fusions
Yalcin K, Alanya H, Gultekin B, Samper Figuera D, Barak T, Miyagishima D, Youngblood M, Hjerthen M, Brooks A, Samuel Lopez N, O’Brien J, Chavez M, Dincer A, Wu H, Omay S, Yasuno K, Bilguvar K, Ercan-Sencicek A, Mishra-Gorur K, McGuone D, Moliterno J, Gunel M, Erson-Omay E. Subgroup of meningiomas involving FOS and FOSB gene fusions. Nature Communications 2025, 16: 10532. PMID: 41298363, PMCID: PMC12657970, DOI: 10.1038/s41467-025-65549-7.Peer-Reviewed Original ResearchConceptsAP-1 target genesRecurrent genomic rearrangementsGene expression patternsGenomic rearrangementsChromosomal alterationsGene fusionsMolecular classificationGenetic driversTarget genesExpression patternsGenesFosB geneLow-grade behaviorTreated with surgerySubgroup of meningiomasClassification of meningiomasProtein levelsDriver mutationsTargeted treatment strategiesCentral nervous systemPrimary tumorBenign subtypeTargeted therapyClinical featuresMolecular subgroupsPathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration
Neuschmid S, Schallerer C, Ehrlich B, McGuone D. Pathological Calcium Signaling in Traumatic Brain Injury and Alzheimer’s Disease: From Acute Neuronal Injury to Chronic Neurodegeneration. International Journal Of Molecular Sciences 2025, 26: 9245. PMID: 41009808, PMCID: PMC12471116, DOI: 10.3390/ijms26189245.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAlzheimer's diseaseCalcium-dependent protease calpainPharmacological inhibitionCalcium signalingTau hyperphosphorylationAmyloid-bLoss of calcium homeostasisProtein misfoldingCalcium-dependent enzymesSignaling proteinsAD riskProtease calpainAD modelProtease networkDisrupted calcium signalingTraumatic brain injuryUpstream driversEnzyme activityPathological calcium signalingSynaptic architectureCalcium dysregulationAxonal transportNeuronal deathEssential scaffoldsCalcium homeostasisCalpain in Traumatic Brain Injury: From Cinderella to Central Player
Schallerer C, Neuschmid S, Ehrlich B, McGuone D. Calpain in Traumatic Brain Injury: From Cinderella to Central Player. Cells 2025, 14: 1253. PMID: 40862734, PMCID: PMC12384584, DOI: 10.3390/cells14161253.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTraumatic brain injuryTherapeutic targetCalcium-dependent protease calpainBrain injuryCause of deathSecondary injury cascadesPreclinical efficacyTraumatic brain injury pathologyGlobal health concernClinical dataRegulatory proteinsCalcium homeostasisInjury cascadeCalcium dysregulationProtein fragmentsProtease calpainCalpain substratesCalpain activityMitochondrial dysfunctionProtease activityAxonal integrityNeuronal compartmentsSelective inhibitorsCentral playerSynaptic functionReclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case
Dincer A, Kim M, Hüseyinoglu Z, Chavez M, McGuone D, Moliterno J. Reclassification of pineal tumor as high-grade astrocytoma with piloid features through methylation profiling: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case24778. PMID: 40324324, PMCID: PMC12051993, DOI: 10.3171/case24778.Peer-Reviewed Original ResearchHigh-grade astrocytomasPiloid featuresHigh-grade neuroepithelial tumorCNS tumor classificationGross-total resectionHigh-grade pathologyEndoscopic third ventriculostomyRight-sided weaknessMethylation profilesClinically relevant changesNeuroepithelial tumorsSuboccipital craniectomyTumor sizePineal tumorsPineal regionThird ventriculostomyTumor typesClinical trialsGlioma subtypesBiopsy samplesDNA methylation profilesTumorTargeted therapeuticsHistological appearanceInterval increaseExploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury
Wachtler N, O’Brien R, Ehrlich B, McGuone D. Exploring Calcium Channels as Potential Therapeutic Targets in Blast Traumatic Brain Injury. Pharmaceuticals 2025, 18: 223. PMID: 40006037, PMCID: PMC11859800, DOI: 10.3390/ph18020223.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCalcium signalingCalcium channelsTherapeutic strategiesCalcium homeostasisFunction of calcium channelsDysregulated calcium signalingModulation of injuryTraumatic brain injuryBrain injuryLoss of calcium homeostasisBlast-related traumatic brain injuryDevelopment of neuroprotective interventionsIntracellular calcium dynamicsPlasma membrane stabilityExtracellular calciumBlast traumatic brain injuryPreclinical modelsTherapeutic outcomesNeuroprotective interventionsMembrane abnormalitiesPharmacological inhibitorsNeuronal somataExclusion criteriaCalcium dynamicsSecondary injurySomatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas
Gupta M, Samiappan S, Alanya H, Yalcin K, Gultekin B, Sharaf R, Elsamadicy A, Figuera D, Samuel N, Mishra-Gorur K, Kolb L, McGuone D, Gunel M, Erson-Omay E, Moliterno J, Mendel E. Somatic SMARCB1 mutation in spinal meningioma represents branched evolution in a patient with multiple sporadic meningiomas. Neuro-Oncology Advances 2025, 7: vdaf067. PMID: 40386121, PMCID: PMC12081948, DOI: 10.1093/noajnl/vdaf067.Peer-Reviewed Original Research
2024
Rocky Mountain Spotted Fever Encephalitis and “Starry Sky” Pattern on MRI
Mikhaiel J, Parasram M, Park J, Cappucci S, McGuone D, Falcone G, Sheth K, Gilmore E. Rocky Mountain Spotted Fever Encephalitis and “Starry Sky” Pattern on MRI. The Neurologist 2024, 30: 34-38. PMID: 39382206, DOI: 10.1097/nrl.0000000000000586.Peer-Reviewed Original ResearchMagnetic resonance imagingPetechial rashCase reportDiffusion restrictionMagnetic resonance imaging brainMagnetic resonance imaging brain findingsRepeat MRI brainRocky Mountain Spotted FeverUrinary tract infectionFoci of diffusion restrictionRight centrum semiovaleProgression to comaPerivascular lymphocytic infiltrateDiffuse petechial rashTract infectionsClinical presentationViral cultureClinical improvementMRI brainLymphocytic infiltrationLumbar punctureSkin biopsiesElevated proteinNeurological manifestationsPunctate fociVariations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group.
Tabor J, Dincer A, O'Brien J, Lei H, Vetsa S, Vasandani S, Jalal M, Yalcin K, Morales-Valero S, Marianayagam N, Alanya H, Elsamadicy A, Millares Chavez M, Aguilera S, Mishra-Gorur K, McGuone D, Fulbright R, Jin L, Erson-Omay E, Günel M, Moliterno J. Variations in the genomic profiles and clinical behavior of meningioma by racial and ethnic group. Journal Of Neurosurgery 2024, 141: 664-672. PMID: 38518289, DOI: 10.3171/2024.1.jns231633.Peer-Reviewed Original ResearchBlack patientsSporadic meningiomasClinical outcomesGenomic profilingClinical behavior of meningiomasShorter progression-free survivalAnterior skull base tumorsClinical data of patientsHispanic patientsProgression-free survivalChromosome 1p deletionBehavior of meningiomasIncreased recurrence rateRate of recurrenceSkull base tumorsData of patientsSomatic driver mutationsNon-black patientsShorter PFSOverall survivalAggressive meningiomasTRAF7 mutationsIntracranial meningiomasMeningioma resectionNon-black group
2023
The clinical and genomic features of seizures in meningiomas
Dincer A, Jalal M, Gupte T, Vetsa S, Vasandani S, Yalcin K, Marianayagam N, Blondin N, Corbin Z, McGuone D, Fulbright R, Erson-Omay Z, Günel M, Moliterno J. The clinical and genomic features of seizures in meningiomas. Neuro-Oncology Advances 2023, 5: i49-i57. PMID: 37287582, PMCID: PMC10243847, DOI: 10.1093/noajnl/vdac110.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeritumoral brain edemaPostoperative seizuresBrain invasionSubtotal resectionBrain edemaLarge residual tumor volumeCentral nervous system tumorsCommon central nervous system tumorPersistent postoperative seizuresResidual tumor volumeHistory of seizuresHigh tumor gradeNervous system tumorsQuality of lifePreoperative seizuresAtypical histologyMost patientsSurgical resectionCortical hyperexcitabilityUncontrolled seizuresAggressive featuresSeizure activityEpileptogenic focusCortical irritationRisk factors
News
News
- January 14, 2026
Meningiomas Subset’s Genetic Drivers Identified
- September 25, 2023
Pathology Office of Research Affairs Makes an Impact
- May 28, 2021
Recent Research Sheds Light on Link Between Meningiomas and Seizures
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