Anna Lynn, MD, PhD
Hospital ResidentAbout
Research
Publications
2026
Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (Macaca mulatta)
Piotrowski-Daspit A, Lynn A, Eaton D, Bracaglia L, Markey A, Mortlock R, Stitelman D, Martinez M, Lee C, Kliman H, Glazer P, Tarantal A, Saltzman W. Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys (Macaca mulatta). Human Gene Therapy 2026, 37: 189-198. PMID: 41645533, PMCID: PMC12978997, DOI: 10.1177/10430342251414881.Peer-Reviewed Original ResearchConceptsfetal rhesus monkeysfetal deliverybiodistribution of polymeric nanoparticlesdelivery of therapeutic nucleic acidsrhesus monkeyspost-administrationlong-term safetytherapeutic nucleic acidsultrasound-guided deliveryNo adverse findingsfetal liverfetal tissuesportal veinanatomical sitesshort-term studiesmRNA expressionadverse findingspolymeric nanoparticlesbiodistributionreporter mRNA expressionMacaca mulattatissuemonkeysspleenpolymer nanoparticles
2025
Systemic in utero gene editing as a treatment for cystic fibrosis
Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl H, Piotrowski-Daspit A, Lopez-Giraldez F, Luks V, Freedman-Weiss M, Farrelly J, Ahle S, Lynn A, Glazer P, Saltzman W, Stitelman D, Egan M. Systemic in utero gene editing as a treatment for cystic fibrosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2418731122. PMID: 40493185, PMCID: PMC12184489, DOI: 10.1073/pnas.2418731122.Peer-Reviewed Original ResearchConceptsutero gene editingcystic fibrosisCF transmembrane conductance regulatortreat CF patientstransmembrane conductance regulatorwild-type miceirreversible organ damagenormal organ developmenttreat monogenic diseasesCFTR activityCF patientsconductance regulatordisease-causing genesmultiorgan diseasedisease improvementorgan damagegene editingmonogenic diseasesmutation correctionpolymeric nanoparticlesgastrointestinal tissuesdiseasebirthfibrosisreproductive systemInvestigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery
Lynn A, Shin K, Eaton D, Rose M, Zhang X, Ene M, Grundler J, Deschenes E, Rivero R, Bracaglia L, Glazer P, Stitelman D, Saltzman W. Investigation of the protein corona and biodistribution profile of polymeric nanoparticles for intra-amniotic delivery. Biomaterials 2025, 320: 123238. PMID: 40064138, PMCID: PMC11972154, DOI: 10.1016/j.biomaterials.2025.123238.Peer-Reviewed Original Researchamniotic fluidprotein corona formationprotein coronaintra-amniotic deliveryNP delivery systemPEGylated nanoparticlessurface polyethylene glycolpoly(lactic-co-glycolic acidprotein corona compositionlung cells in vitrocorona formationPLA-PEG nanoparticlesnon-PEGylated nanoparticlescells in vitrolevels of albuminfetal bowelfetal lungfetal organsNP biodistributionpoly(lactic-aciddense brush conformationcorona compositionpolyvinyl alcoholbiodistribution profilecellular associationPTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
DeSpenza T, Kiziltug E, Allington G, Barson D, McGee S, O’Connor D, Robert S, Mekbib K, Nanda P, Greenberg A, Singh A, Duy P, Mandino F, Zhao S, Lynn A, Reeves B, Marlier A, Getz S, Nelson-Williams C, Shimelis H, Walsh L, Zhang J, Wang W, Prina M, OuYang A, Abdulkareem A, Smith H, Shohfi J, Mehta N, Dennis E, Reduron L, Hong J, Butler W, Carter B, Deniz E, Lake E, Constable R, Sahin M, Srivastava S, Winden K, Hoffman E, Carlson M, Gunel M, Lifton R, Alper S, Jin S, Crair M, Moreno-De-Luca A, Luikart B, Kahle K. PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors. Nature Neuroscience 2025, 28: 536-557. PMID: 39994410, PMCID: PMC12038823, DOI: 10.1038/s41593-024-01865-3.Peer-Reviewed Original ResearchConceptsneural progenitor cellscongenital hydrocephalusCSF dynamicsincreased CSF productionde novo mutationsfrequent monogenic causeeverolimus treatmentCSF shuntingnonsurgical treatmentPTEN mutationsaqueductal stenosisinhibitory interneuronsventriculomegalyprogenitor cellschoroid plexusmonogenic causecortical networksIncreased Survivalbrain ventriclescortical deficitsneural progenitorsgene PTENCSF productionNkx2.1PTEN
2024
Opportunities for Incorporation of Primary Palliative Care in Acute Care Surgery: A Narrative Review
Lynn A, Miller S, Brackett A, Kodadek L. Opportunities for Incorporation of Primary Palliative Care in Acute Care Surgery: A Narrative Review. American Journal Of Hospice And Palliative Medicine® 2024, 43: 113-122. PMID: 39680802, DOI: 10.1177/10499091241309087.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementsprimary palliative careacute care surgerypalliative carepalliative care principlespractice of acute care surgeryacute care surgical patientsnarrative reviewprimary surgical teamcaregiver supportsymptom managementcare principlesclinician perspectivesseverity of illnesspalliative interventionscaresignificant barrierspractice existpromote educationidentification of patientsincreased awarenessbenefit patientssurgical traineessurgical settingpatient populationcultural factorsBiodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate
Eaton D, Lynn A, Surprenant J, Deschenes E, Guerra M, Rivero R, Yung N, O'Connor M, Glazer P, Bahtiyar M, Saltzman W, Stitelman D. Biodistribution of Polymeric Nanoparticles following in utero Delivery to a Nonhuman Primate. Biomedicine Hub 2024, 10: 543138. PMID: 39845408, PMCID: PMC11753793, DOI: 10.1159/000543138.Peer-Reviewed Original Researchmonogenic diseasesnon-human primatesbiodistribution of polymeric nanoparticlespreclinical mouse modelsstem cell populationfetal liverfetal malessystemic deliveryfetal bonesaccumulation of NPin-uteromid-gestationNP accumulationbiodistribution studiespolymeric NPstherapeutic accesscell populationsmaternal tissueszone of proliferationpolymeric nanoparticlesdiseasebirthmicedeliverybiodistributionThe Association of Polycystic Ovarian Syndrome and Adnexal Pathologies in Adolescents
Lynn A, Lepore C, Solomon N, Zamani M, Sailer A, Kuehne A, Rowe E, Vash-Margita A. The Association of Polycystic Ovarian Syndrome and Adnexal Pathologies in Adolescents. Journal Of Obstetrics And Gynaecology Canada 2024, 46: 102634. PMID: 39142633, DOI: 10.1016/j.jogc.2024.102634.Peer-Reviewed Original ResearchThe Technical and Ethical framework of Fetal Therapy: Past and Current Advances
Lynn, A.Y., Glazer, P.M., Saltzman, W.M. et al. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Curr Stem Cell Rep 10, 30–36 (2024). https://doi.org/10.1007/s40778-024-00235-wPeer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThe Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Lynn A, Glazer P, Saltzman W, Stitelman D. The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances. Current Stem Cell Reports 2024, 10: 30-36. PMID: 41048874, PMCID: PMC12490801, DOI: 10.1007/s40778-024-00235-w.Peer-Reviewed Original Researchfetal drug deliverysuccess of nanomedicinedrug deliverypharmacological drug treatmentsminimally invasive strategyfetal therapyfetal applicationsclinical studiescongenital diseaseinvasive strategydrug treatmentclinical translationclinical practicetherapymedical interventionsdeliveryfetalnanomedicinebirthdiseaseFindingsAclinicians
2022
Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome
Lynn A, Solomon N, Zamani M, Rowe E, Seifer D, Vash-Margita A. Evaluation of the Association of Endometrial Thickness, Insulin Resistance, and Menstrual Patterns in Adolescent Females with Polycystic Ovarian Syndrome. Journal Of Pediatric And Adolescent Gynecology 2022, 36: 134-139. PMID: 36403727, DOI: 10.1016/j.jpag.2022.11.005.Peer-Reviewed Original ResearchConceptsPCOS groupinsulin resistancemenstrual patternadolescent femalescontrol groupretrospective case-control studylarge-scale prospective studiesacute pelvic painendometrial stripe thicknesstransabdominal pelvic ultrasoundtertiary children's hospitalpolycystic ovarian syndromebody mass indexcase-control studyinstitutional review boardadolescent PCOSendometrial thicknesspelvic painovarian syndromePCOS diagnosispelvic ultrasoundunique pathophysiologyendocrinology clinicChildren's Hospitalmass index
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