Publications

2025

Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade.
Talty R, Brooks V, McGeary M, Milette S, Zheng S, Flem-Karlsen K, Daniels A, Deshmukh M, Park K, Caraccio W, Yan H, Echeandia-Francis C, McNamara M, Hong S, Kirwin D, Olino K, Johnson C, Bosenberg M, Micevic G, Roy S. Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade. Molecular Cancer Therapeutics 2025, of1-of12. PMID: 41423587, PMCID: PMC12752129, DOI: 10.1158/1535-7163.mct-25-0667.
Peer-Reviewed Original Research
Concepts
488 EGFR-STAT1 Pathway Drives Fibrosis Initiation in Fibroinflammatory Skin Diseases
Odell A, Newton N, Eisenstein A, Micevic G, Flavell R, Odell I. 488 EGFR-STAT1 Pathway Drives Fibrosis Initiation in Fibroinflammatory Skin Diseases. Journal Of Investigative Dermatology 2025, 145: s352. DOI: 10.1016/j.jid.2025.10.500.
Peer-Reviewed Original Research
167 Single-cell RNA sequencing nominates LAG3 as a potential therapeutic target for alopecia areata
Sanchez E, Wang Y, Kalil L, Peterson D, Hwang E, Yu W, Micevic G, Park K, King B, Damsky W. 167 Single-cell RNA sequencing nominates LAG3 as a potential therapeutic target for alopecia areata. Journal Of Investigative Dermatology 2025, 145: e58. DOI: 10.1016/j.jid.2025.09.182.
Peer-Reviewed Original Research
EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases
Odell A, Newton N, Eisenstein A, Micevic G, Flavell R, Odell I. EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases. Nature Communications 2025, 16: 8969. PMID: 41068129, PMCID: PMC12511620, DOI: 10.1038/s41467-025-64648-9.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity.
Flem-Karlsen K, Talty R, McGeary M, Park K, Thakral D, Brooks V, Daniels A, Damsky W, Roy S, Micevic G, Bosenberg M. Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity. Cancer Research 2025, 85: 4139-4150. PMID: 40828991, DOI: 10.1158/0008-5472.can-24-1952.
Peer-Reviewed Original Research
Concepts
0065 DNA methyltransferase inhibition as a strategy to potentiate anti-tumor CD8+ T cell function in melanoma
Deshmukh M, Bosenberg M, Micevic G. 0065 DNA methyltransferase inhibition as a strategy to potentiate anti-tumor CD8+ T cell function in melanoma. Journal Of Investigative Dermatology 2025, 145: s11. DOI: 10.1016/j.jid.2025.06.066.
Peer-Reviewed Original Research
Concepts
Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma
Aung T, Liu M, Su D, Shafi S, Boyaci C, Steen S, Tsiknakis N, Vidal J, Maher N, Micevic G, Tan S, Vesely M, Nourmohammadi S, Bai Y, Djureinovic D, Wong P, Bates K, Chan N, Gavirelatou N, He M, Burela S, Barna R, Bosic M, Bräutigam K, Illabochaca I, Chenhao Z, Gama J, Kreis B, Mohacsi R, Pillar N, Pinto J, Poulios C, Toli M, Tzoras E, Bracero Y, Bosisio F, Cserni G, Dema A, Fortarezza F, Gonzalez M, Gullo I, Gutiérrez F, Hacihasanoglu E, Jovic V, Lazar B, Olinca M, Neppl C, Oliveira R, Pezzuto F, Pinto D, Plotar V, Pop O, Rau T, Skok K, Sun W, Serbes E, Solass W, Stanowska O, Szasz M, Szymonski K, Thimm F, Vignati D, Vigdorovits A, Prieto V, Sinnberg T, Wilmott J, Cowper S, Warrell J, Saenger Y, Hartman J, Plummer J, Osman I, Rimm D, Acs B. Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma. JAMA Network Open 2025, 8: e2518906. PMID: 40608341, PMCID: PMC12232186, DOI: 10.1001/jamanetworkopen.2025.18906.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities
Deshmukh M, Brooks V, Roy S, Milette S, Bosenberg M, Micevic G. DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities. Clinical Epigenetics 2025, 17: 71. PMID: 40307913, PMCID: PMC12044936, DOI: 10.1186/s13148-025-01865-5.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Epigenetic therapy sensitizes anti–PD-1 refractory head and neck cancers to immunotherapy rechallenge
Qin T, Mattox A, Campbell J, Park J, Shin K, Li S, Sadow P, Faquin W, Micevic G, Daniels A, Haddad R, Garris C, Pittet M, Mempel T, ONeill A, Sartor M, Pai S. Epigenetic therapy sensitizes anti–PD-1 refractory head and neck cancers to immunotherapy rechallenge. Journal Of Clinical Investigation 2025, 135: e181671. PMID: 40091844, PMCID: PMC11910227, DOI: 10.1172/jci181671.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Engineering Mice to Study Human Immunity
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025, 43: 451-487. PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.
Peer-Reviewed Original Research
Concepts
Non-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis
Balter D, Cao Y, Garritano J, Micevic G, Sanchez A. Non-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis. Clinical Nephrology - Case Studies 2025, 13: 8-12. PMID: 39949516, PMCID: PMC11823000, DOI: 10.5414/cncs111578.
Peer-Reviewed Original Research
Concepts

2024

2023

2022

The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.
Micevic G, Bosenberg M, Yan Q. The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy. Clinical Cancer Research 2022, 29: 1173-1182. PMID: 36449280, PMCID: PMC10073242, DOI: 10.1158/1078-0432.ccr-22-0784.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts

See All Publications

Publications

2025

Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint Blockade.

488 EGFR-STAT1 Pathway Drives Fibrosis Initiation in Fibroinflammatory Skin Diseases

167 Single-cell RNA sequencing nominates LAG3 as a potential therapeutic target for alopecia areata

EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases

Cytotoxic CD8+ T Cells Downregulate GPX4 to Promote Ferroptosis in Melanoma That Drives Antitumor Immunity.

0065 DNA methyltransferase inhibition as a strategy to potentiate anti-tumor CD8+ T cell function in melanoma

Pathologist-Read vs AI-Driven Assessment of Tumor-Infiltrating Lymphocytes in Melanoma

DNA methylation in melanoma immunotherapy: mechanisms and therapeutic opportunities

Epigenetic therapy sensitizes anti–PD-1 refractory head and neck cancers to immunotherapy rechallenge

Engineering Mice to Study Human Immunity

Non-uremic calciphylaxis: A dermatologic complication in both MASH and alcohol-associated cirrhosis

2024

The 2024 generation

Setdb1 Loss Induces Type I Interferons and Immune Clearance of Melanoma.

Clinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas

057 Single cell RNA and TCR sequencing reveals hyperexpansion of T cell clones and novel regulatory mechanisms of CD8+ T cells in murine alopcecia areata skin and draining lymph nodes

Tumour necrosis is a valuable histopathological prognostic parameter in melanomas of the vulva and vagina

Melanoma tumour-infiltrating T-lymphocyte therapy heralds the era of cell-based immunotherapies for solid tumours

Cutaneous diatoms from diatomaceous earth mimicking myiasis infection

2023

1025 Tumor-specific CD8+ T cells epigenetically licensed by IL-7R are critical for anti-tumor immunity in melanoma

Pot1b −/− tumors activate G-quadruplex-induced DNA damage to promote telomere hyper-elongation

New insights into programmed cell death protein 1 blockade-associated cutaneous immune-related adverse events

IL-7R licenses a population of epigenetically poised memory CD8+ T cells with superior antitumor efficacy that are critical for melanoma memory

1234 Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma

ISID1234 - Immunotherapy induces clonal expansion of cytotoxic tumor-specific TILs in a model of melanoma

2022

The Crossroads of Cancer Epigenetics and Immune Checkpoint Therapy.