McAlpine Lab

Long COVID is a pressing public health issue affecting almost millions of Americans. Our goal is to understand and address the mechanisms that damage nervous system after COVID-19. Our studies focus on the underlying neuropathophysiology of Long COVID using a variety of modalities. All our methods are concentrated on imaging, data, and samples collected from humans to understand damage to the central, autonomic, and peripheral nervous systems. Our research participants are recruited locally and throughout the United States. We work with a wide range of collaborators at Yale University and beyond. The main modality we use is advanced research-based MRI of the brain. We apply a wide range of sequences including structural, vascular, and other techniques. Other tools we have recently applied include vascular, neuronal, and immunologic biomarker testing, as well as extensive neuropsychological testing.