Our overall goal is to understand how regulation of the muscular layer of blood vessels contributes to normal vessel function and to cardiovascular disease. Hyperproliferation or dysfunction in vascular smooth muscle cells contributes to atherosclerosis, hypertension, organ transplant failure, and failure of revascularization therapies such as balloon angioplasty or bypass surgery. By understanding the regulatory mechanisms of vascular smooth muscle, we aim to develop new therapies for treatment and prevention of cardiovascular diseases.
Key areas of interest: Vascular smooth muscle; Differentiation; Signal transduction; Transcription; Epigenetics
Disease models: Atherosclerosis, Intimal Hyperplasia, Transplant Vasculopathy, Obesity and Diabetes