Publications

2026

Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease
Joshi D, Rukhlenko O, Tuliakova A, Sun Z, Bhogale T, Furtado J, Traylor J, Imoto H, Orr A, Tellides G, Martin K, Kholodenko B, Schwartz M. Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2603888123. PMID: 42673460, PMCID: PMC13552879, DOI: 10.1073/pnas.2603888123.
Peer-Reviewed Original Research
MeSH Keywords

2025

Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation
Schwartz A, Li Z, Bai H, Ho B, Lazcano-Etchebarne C, Gonzalez L, Kano M, Chaar C, Martin K, Vazquez-Padron R, Dai G, Dardik A. Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation. JVS Vascular Science 2025, 6: 100392. PMID: 41127450, PMCID: PMC12538405, DOI: 10.1016/j.jvssci.2025.100392.
Peer-Reviewed Original Research
SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity
Chatterjee P, Sizer A, O’Brien B, Xu P, Hwa J, Xie Y, Yan Q, Hwa J, Martin K. SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity. Arteriosclerosis Thrombosis And Vascular Biology 2025, 45: 2015-2033. PMID: 40836920, DOI: 10.1161/atvbaha.124.322179.
Peer-Reviewed Original Research
Prostacyclin enlists AC6 to stop the clot
Martin K, Ostrom R, Hwa J. Prostacyclin enlists AC6 to stop the clot. Journal Of Thrombosis And Haemostasis 2025, 23: 2390-2392. PMID: 40738584, PMCID: PMC13500921, DOI: 10.1016/j.jtha.2025.04.008.
Peer-Reviewed Original Research
Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure
Gonzalez L, Bai H, Taniguchi R, Ramachandra A, Jovin D, Nguyen M, Thaxton C, Vazquez-Padron R, Humphrey J, Martin K, Kyriakides T, Dardik A. Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure. AJP Heart And Circulatory Physiology 2025, 328: h1147-h1167. PMID: 40247455, PMCID: PMC12150301, DOI: 10.1152/ajpheart.00661.2024.
Peer-Reviewed Original Research
MeSH Keywords
Changes in vascular identity during vascular remodeling
Schwartz A, Li Z, Bai H, Gonzalez L, Etchebarne C, Kano M, Ho B, Martin K, Dardik A. Changes in vascular identity during vascular remodeling. JVS Vascular Science 2025, 6: 100282. PMID: 40213096, PMCID: PMC11985068, DOI: 10.1016/j.jvssci.2025.100282.
Peer-Reviewed Original Research

2024

Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease
Gonzalez L, Li X, Bai H, Li Z, Taniguchi R, Thaxton C, Martin K, Goodwin J, Tellides G, Long X, Shu C, Dardik A. Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44: 2509-2526. PMID: 39297205, PMCID: PMC11593991, DOI: 10.1161/atvbaha.124.320933.
Peer-Reviewed Original Research
Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis
Agyemang A, Saito J, Ballabh P, Martin K, Greif D. Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis. Stroke 2024, 55: 2340-2352. PMID: 39129597, PMCID: PMC11347087, DOI: 10.1161/strokeaha.123.045248.
Peer-Reviewed Original Research
A Concept of “Athero-Oncology”: Tumor-Like Smooth Muscle Cells Drive Atherosclerosis
Chatterjee P, Martin K. A Concept of “Athero-Oncology”: Tumor-Like Smooth Muscle Cells Drive Atherosclerosis. Circulation 2024, 149: 1899-1902. PMID: 38857330, PMCID: PMC12051038, DOI: 10.1161/circulationaha.124.069446.
Commentaries, Editorials and Letters
MeSH Keywords

2023

TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes
Fowler J, Grabinska K, Cardone R, Sun Q, Vazquez K, Whalen M, Martin K, Simons M, Romanoski C, Kibbey R, Sessa W. TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2218150120. PMID: 37695914, PMCID: PMC10515159, DOI: 10.1073/pnas.2218150120.
Peer-Reviewed Original Research
MeSH Keywords
Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability
Wu Q, Hu X, Wang Y, Lu J, Martin K, Guo S. Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability. Stem Cells 2023, 41: 907-915. PMID: 37386941, PMCID: PMC11009695, DOI: 10.1093/stmcls/sxad051.
Peer-Reviewed Original Research
MeSH Keywords
Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model
Satam K, Thaxton C, Gonzalez L, Bai H, Xie Y, Martin K, Cai Y, Dardik A. Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model. AJP Heart And Circulatory Physiology 2023, 325: h77-h88. PMID: 37145957, PMCID: PMC10243550, DOI: 10.1152/ajpheart.00049.2023.
Peer-Reviewed Original Research
MeSH Keywords
The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques
Zhang X, Qu R, Chandran R, Gallardo-Vara E, Aryal B, Rotllan N, Garcia-Milian R, Hwa J, Kluger Y, Martin K, Fernández-Hernando C, Greif D. The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques. Nature Aging 2023, 3: 64-81. PMID: 36743663, PMCID: PMC9894379, DOI: 10.1038/s43587-022-00342-5.
Peer-Reviewed Original Research
This study shows that aged bone marrow drives polyclonal smooth muscle cell expansion in atherosclerotic plaques via a TET2–integrin β3–TNFα signaling pathway.
Full Summary
“Cre”ating New Tools for Smooth Muscle Analysis
O’Brien B, Martin K, Offermanns S. “Cre”ating New Tools for Smooth Muscle Analysis. Arteriosclerosis Thrombosis And Vascular Biology 2023, 43: 212-214. PMID: 36601960, PMCID: PMC10112502, DOI: 10.1161/atvbaha.122.318855.
Commentaries, Editorials and Letters
MeSH Keywords

2022

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells
Tyagi T, Jain K, Yarovinsky TO, Chiorazzi M, Du J, Castro C, Griffin J, Korde A, Martin KA, Takyar SS, Flavell RA, Patel AA, Hwa J. Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells. Journal Of Experimental Medicine 2022, 220: e20212218. PMID: 36305874, PMCID: PMC9814191, DOI: 10.1084/jem.20212218.
Peer-Reviewed Original Research
MeSH Keywords
Better together
Martin K, Hwa J. Better together. Science 2022, 378: 442-442. PMID: 36302027, DOI: 10.1126/science.adf4466.
Peer-Reviewed Original Research
Unfolded Protein Response Differentially Modulates the Platelet Phenotype
Jain K, Tyagi T, Du J, Hu X, Patell K, Martin KA, Hwa J. Unfolded Protein Response Differentially Modulates the Platelet Phenotype. Circulation Research 2022, 131: 290-307. PMID: 35862006, PMCID: PMC9357223, DOI: 10.1161/circresaha.121.320530.
Peer-Reviewed Original Research
MeSH Keywords
Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity
Ostriker AC, Xie Y, Gamez-Mendez A, Chatterjee P, Abu Y, Valentine J, Lezon-Geyda K, Greif DM, Schulz VP, Gallagher PG, Sessa WC, Hwa J, Martin KA. Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. Circulation 2022, 145: 1720-1737. PMID: 35502657, PMCID: PMC12047542, DOI: 10.1161/circulationaha.121.057599.
Peer-Reviewed Original Research
MeSH Keywords
Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification
Jung JJ, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.
Peer-Reviewed Original Research
Sugar, Fat, and YAP: A Recipe for Vascular Stiffness
Mani A, Hwa J, Martin KA. Sugar, Fat, and YAP: A Recipe for Vascular Stiffness. Circulation Research 2022, 130: 868-870. PMID: 35298300, PMCID: PMC9112226, DOI: 10.1161/circresaha.122.320880.
Commentaries, Editorials and Letters
MeSH Keywords
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
Tyagi T, Jain K, Gu S, Qiu M, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency
Saito J, Feng Z, Misra A, Tellides G, Riemer RK, Urban Z, Kinnear C, Ellis J, Mital S, Mecham R, Martin KA, Greif DM. JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency. Journal Of Clinical Investigation 2022, 132: e142338. PMID: 34990407, PMCID: PMC8884911, DOI: 10.1172/jci142338.
Peer-Reviewed Original Research
MeSH Keywords

2021

See All Publications

Publications

2026

Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease

2025

Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation

SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity

Prostacyclin enlists AC6 to stop the clot

Sustained tenascin-C expression drives neointimal hyperplasia and promotes aortocaval fistula failure

Changes in vascular identity during vascular remodeling

2024

Endothelial TGF-β Signaling Regulates Endothelial-Mesenchymal Transition During Arteriovenous Fistula Remodeling in Mice With Chronic Kidney Disease

Loss of TGFβ-Mediated Repression of Angiopoietin-2 in Pericytes Underlies Germinal Matrix Hemorrhage Pathogenesis

A Concept of “Athero-Oncology”: Tumor-Like Smooth Muscle Cells Drive Atherosclerosis

2023

TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes

Serum Response Factor Reduces Gene Expression Noise and Confers Cell State Stability

Sex hormones impact early maturation and immune response in the arteriovenous fistula mouse model

The age of bone marrow dictates the clonality of smooth muscle-derived cells in atherosclerotic plaques

“Cre”ating New Tools for Smooth Muscle Analysis

2022

Platelet-derived TLT-1 promotes tumor progression by suppressing CD8+ T cells

Better together

Unfolded Protein Response Differentially Modulates the Platelet Phenotype

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity

Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification

Sugar, Fat, and YAP: A Recipe for Vascular Stiffness

A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences

JAGGED1/NOTCH3 activation promotes aortic hypermuscularization and stenosis in elastin deficiency

2021

Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis

H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

TET2 Protects Against Vascular Smooth Muscle Cell Apoptosis and Intimal Thickening in Transplant Vasculopathy