All Publications

• Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase.Skeens E, Maschietto F, Manjula R, Shillingford S, Lolis EJ, Batista VS, Bennett AM, Lisi GP. bioRxiv. 2024 Sep 5; 2024 Sep 5. PMID: 39282375.
• A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus.Li J, Leng L, Pantouris G, Manjula R, Piecychna M, Abriola L, Hu B, Lolis E, Armstrong ME, Donnelly SC, Bucala R. J Biol Chem. 2024 Jul; 2024 Jun 3. PMID: 38838773.
• Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose.Bloom J, Pantouris G, He M, Aljabari B, Mishra L, Manjula R, Parkins A, Lolis EJ, Al-Abed Y. Mol Med. 2024 Mar 27; 2024 Mar 27. PMID: 38539088.
• Plant MDL proteins synergize with the cytokine MIF at CXCR2 and CXCR4 receptors in human cells.Spiller L, Manjula R, Leissing F, Basquin J, Bourilhon P, Sinitski D, Brandhofer M, Levecque S, Gerra S, Sabelleck B, Zhang L, Feederle R, Flatley A, Hoffmann A, Panstruga R, Bernhagen J, Lolis E. Sci Signal. 2023 Nov 21; 2023 Nov 21. PMID: 37988455.
• Mapping N- to C-terminal allosteric coupling through disruption of a putative CD74 activation site in D-dopachrome tautomerase.Chen E, Widjaja V, Kyro G, Allen B, Das P, Prahaladan VM, Bhandari V, Lolis EJ, Batista VS, Lisi GP. J Biol Chem. 2023 Jun; 2023 Apr 18. PMID: 37080391.
• Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism.Maschietto F, Qiu T, Wang J, Shi Y, Allen B, Lisi GP, Lolis E, Batista VS. Comput Struct Biotechnol J. 2023; 2023 Jan 16. PMID: 36688026.
• Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors.Gannam ZTK, Jamali H, Kweon OS, Herrington J, Shillingford SR, Papini C, Gentzel E, Lolis E, Bennett AM, Ellman JA, Anderson KS. Eur J Med Chem. 2022 Dec 5; 2022 Sep 2. PMID: 36116232.
• A novel site on dual-specificity phosphatase MKP7/DUSP16 is required for catalysis and MAPK binding.Shillingford S, Zhang L, Surovtseva Y, Dorry S, Lolis E, Bennett AM. J Biol Chem. 2022 Dec; 2022 Oct 19. PMID: 36272649.
• How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM.Wang J, Liu J, Gisriel CJ, Wu S, Maschietto F, Flesher DA, Lolis E, Lisi GP, Brudvig GW, Xiong Y, Batista VS. J Struct Biol. 2022 Dec; 2022 Oct 3. PMID: 36202310.
• Structural Insights into Binding of Remdesivir Triphosphate within the Replication-Transcription Complex of SARS-CoV-2.Wang J, Shi Y, Reiss K, Maschietto F, Lolis E, Konigsberg WH, Lisi GP, Batista VS. Biochemistry. 2022 Sep 20; 2022 Aug 31. PMID: 36044776.
• Insights into Binding of Single-Stranded Viral RNA Template to the Replication-Transcription Complex of SARS-CoV-2 for the Priming Reaction from Molecular Dynamics Simulations.Wang J, Shi Y, Reiss K, Allen B, Maschietto F, Lolis E, Konigsberg WH, Lisi GP, Batista VS. Biochemistry. 2022 Mar 15; 2022 Feb 24. PMID: 35199520.
• A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.Skeens E, Pantouris G, Shah D, Manjula R, Ombrello MJ, Maluf NK, Bhandari V, Lisi GP, Lolis EJ. Front Mol Biosci. 2022; 2022 Feb 8. PMID: 35252348.
• MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.Tilstam PV, Schulte W, Holowka T, Kim BS, Nouws J, Sauler M, Piecychna M, Pantouris G, Lolis E, Leng L, Bernhagen J, Fingerle-Rowson G, Bucala R. J Clin Invest. 2021 Dec 1. PMID: 34850744.
• Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria.Baeza Garcia A, Siu E, Du X, Leng L, Franke-Fayard B, Janse CJ, Howland SW, Rénia L, Lolis E, Bucala R. FASEB J. 2021 Dec. PMID: 34719814.
• A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase.Chen E, Reiss K, Shah D, Manjula R, Allen B, Murphy EL, Murphy JW, Batista VS, Bhandari V, Lolis EJ, Lisi GP. J Biol Chem. 2021 Sep; 2021 Aug 9. PMID: 34384784.
• Mechanism of Inhibition of the Reproduction of SARS-CoV-2 and Ebola Viruses by Remdesivir.Wang J, Reiss K, Shi Y, Lolis E, Lisi GP, Batista VS. Biochemistry. 2021 Jun 22; 2021 Jun 10. PMID: 34110129.
• Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level.Wang J, Maschietto F, Guberman-Pfeffer MJ, Reiss K, Allen B, Xiong Y, Lolis E, Batista VS. Comput Struct Biotechnol J. 2021; 2021 Sep 3. PMID: 34540146.
• Unraveling the mechanism of recognition of the 3' splice site of the adenovirus major late promoter intron by the alternative splicing factor PUF60.Hsiao HT, Crichlow GV, Murphy JW, Folta-Stogniew EJ, Lolis EJ, Braddock DT. PLoS One. 2020; 2020 Nov 30. PMID: 33253191.
• The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity.Rosenberg EM Jr, Herrington J, Rajasekaran D, Murphy JW, Pantouris G, Lolis EJ. Acta Crystallogr D Struct Biol. 2020 Oct 1; 2020 Sep 25. PMID: 33021505.
• An allosteric site on MKP5 reveals a strategy for small-molecule inhibition.Gannam ZTK, Min K, Shillingford SR, Zhang L, Herrington J, Abriola L, Gareiss PC, Pantouris G, Tzouvelekis A, Kaminski N, Zhang X, Yu J, Jamali H, Ellman JA, Lolis E, Anderson KS, Bennett AM. Sci Signal. 2020 Aug 25; 2020 Aug 25. PMID: 32843541.
• High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity.Murphy JW, Rajasekaran D, Merkel J, Skeens E, Keeler C, Hodsdon ME, Lisi GP, Lolis E. Front Mol Biosci. 2020; 2020 Jul 16. PMID: 32766282.
• Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.Pantouris G, Khurana L, Ma A, Skeens E, Reiss K, Batista VS, Lisi GP, Lolis EJ. Cell Chem Biol. 2020 Jun 18; 2020 May 19. PMID: 32433911.
• A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity.Tilstam PV, Pantouris G, Corman M, Andreoli M, Mahboubi K, Davis G, Du X, Leng L, Lolis E, Bucala R. J Biol Chem. 2019 Dec 6; 2019 Oct 2. PMID: 31578280.
• Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.Rosenberg EM Jr, Harrison RES, Tsou LK, Drucker N, Humphries B, Rajasekaran D, Luker KE, Wu CH, Song JS, Wang CJ, Murphy JW, Cheng YC, Shia KS, Luker GD, Morikis D, Lolis EJ. Cell Chem Biol. 2019 May 16; 2019 Feb 28. PMID: 30827936.
• Expression, purification and crystallization of the novel Xenopus tropicalis ALDH16B1, a homologue of human ALDH16A1.Pantouris G, Dioletis E, Chen Y, Thompson DC, Vasiliou V, Lolis EJ. Chem Biol Interact. 2019 May 1; 2019 Mar 17. PMID: 30894314.
• Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor.Pantouris G, Bucala R, Lolis EJ. Biochemistry. 2018 Jul 3; 2018 Jun 12. PMID: 29847104.
• Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74.Pantouris G, Ho J, Shah D, Syed MA, Leng L, Bhandari V, Bucala R, Batista VS, Loria JP, Lolis EJ. Angew Chem Int Ed Engl. 2018 Jun 11; 2018 May 9. PMID: 29669180.
• Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4.Lacy M, Kontos C, Brandhofer M, Hille K, Gröning S, Sinitski D, Bourilhon P, Rosenberg E, Krammer C, Thavayogarajah T, Pantouris G, Bakou M, Weber C, Lolis E, Bernhagen J, Kapurniotu A. Sci Rep. 2018 Mar 26; 2018 Mar 26. PMID: 29581527.
• CD74 is a novel transcription regulator.Gil-Yarom N, Radomir L, Sever L, Kramer MP, Lewinsky H, Bornstein C, Blecher-Gonen R, Barnett-Itzhaki Z, Mirkin V, Friedlander G, Shvidel L, Herishanu Y, Lolis EJ, Becker-Herman S, Amit I, Shachar I. Proc Natl Acad Sci U S A. 2017 Jan 17; 2016 Dec 28. PMID: 28031488.
• Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74.Meza-Romero R, Benedek G, Jordan K, Leng L, Pantouris G, Lolis E, Bucala R, Vandenbark AA. Cytokine. 2016 Dec; 2016 Aug 27. PMID: 27573366.
• Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.Rajasekaran D, Gröning S, Schmitz C, Zierow S, Drucker N, Bakou M, Kohl K, Mertens A, Lue H, Weber C, Xiao A, Luker G, Kapurniotu A, Lolis E, Bernhagen J. J Biol Chem. 2016 Jul 22; 2016 May 19. PMID: 27226569.
• Conformational dynamics of Ca2+-dependent responses in the polycystin-2 C-terminal tail.Yang Y, Hodsdon ME, Lolis EJ, Ehrlich BE. Biochem J. 2016 Feb 1; 2015 Nov 16. PMID: 26574436.
• Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients.Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Averdunk L, Sun Y, Rossaint R, Lue H, Huang C, Song Y, Pantouris G, Lolis E, Leng L, Schulte W, Bucala R, Weber C, Bernhagen J. Antioxid Redox Signal. 2015 Oct 10; 2015 Aug 11. PMID: 26234719.
• An Analysis of MIF Structural Features that Control Functional Activation of CD74.Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ. Chem Biol. 2015 Sep 17; 2015 Sep 10. PMID: 26364929.
• Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding properties.Yang Y, Keeler C, Kuo IY, Lolis EJ, Ehrlich BE, Hodsdon ME. J Biol Chem. 2015 Apr 17; 2015 Feb 25. PMID: 25716316.
• Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment.Rajasekaran D, Zierow S, Syed M, Bucala R, Bhandari V, Lolis EJ. FASEB J. 2014 Nov; 2014 Jul 11. PMID: 25016026.
• Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors.Pantouris G, Rajasekaran D, Baeza Garcia A, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ. J Med Chem. 2014 Oct 23; 2014 Oct 8. PMID: 25268646.
• ISO-66, a novel inhibitor of macrophage migration, shows efficacy in melanoma and colon cancer models.Ioannou K, Cheng KF, Crichlow GV, Birmpilis AI, Lolis EJ, Tsitsilonis OE, Al-Abed Y. Int J Oncol. 2014 Oct; 2014 Jul 22. PMID: 25050663.
• Structural insight into the evolution of a new chemokine family from zebrafish.Rajasekaran D, Fan C, Meng W, Pflugrath JW, Lolis EJ. Proteins. 2014 May; 2013 Dec 14. PMID: 23900850.
• Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7.Ehrlich A, Ray P, Luker KE, Lolis EJ, Luker GD. Biochem Pharmacol. 2013 Nov 1; 2013 Aug 22. PMID: 23973527.
• MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ. Proc Natl Acad Sci U S A. 2013 Jul 2; 2013 Jun 17. PMID: 23776208.
• Inhibition of paclitaxel-induced decreases in calcium signaling.Benbow JH, Mann T, Keeler C, Fan C, Hodsdon ME, Lolis E, DeGray B, Ehrlich BE. J Biol Chem. 2012 Nov 2; 2012 Sep 17. PMID: 22988235.
• Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.Crichlow GV, Fan C, Keeler C, Hodsdon M, Lolis EJ. Biochemistry. 2012 Sep 25; 2012 Sep 11. PMID: 22931430.
• A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria.Sun T, Holowka T, Song Y, Zierow S, Leng L, Chen Y, Xiong H, Griffith J, Nouraie M, Thuma PE, Lolis E, Janse CJ, Gordeuk VR, Augustijn K, Bucala R. Proc Natl Acad Sci U S A. 2012 Jul 31; 2012 Jul 9. PMID: 22778413.
• A model of GAG/MIP-2/CXCR2 interfaces and its functional effects.Rajasekaran D, Keeler C, Syed MA, Jones MC, Harrison JK, Wu D, Bhandari V, Hodsdon ME, Lolis EJ. Biochemistry. 2012 Jul 17; 2012 Jul 2. PMID: 22686371.
• Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors.Cho Y, Vermeire JJ, Merkel JS, Leng L, Du X, Bucala R, Cappello M, Lolis E. Chem Biol. 2011 Sep 23. PMID: 21944748.
• The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, Bucala R. Proc Natl Acad Sci U S A. 2011 Aug 23; 2011 Aug 4. PMID: 21817065.
• Protein crystallization facilitated by molecularly imprinted polymers.Saridakis E, Khurshid S, Govada L, Phan Q, Hawkins D, Crichlow GV, Lolis E, Reddy SM, Chayen NE. Proc Natl Acad Sci U S A. 2011 Jul 5; 2011 Jun 20. PMID: 21690356.
• K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Åkerström G, Wang W, Carling T, Lifton RP. Science. 2011 Feb 11. PMID: 21311022.
• A small-molecule macrophage migration inhibitory factor antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice.Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, Nikolic-Paterson D, Bucala R. J Immunol. 2011 Jan 1; 2010 Nov 24. PMID: 21106847.
• When anti-CCR2 treatment for arthritis strikes out.Cho Y, Lolis E. Arthritis Rheum. 2011 Jan. PMID: 20967856.
• Two independent histidines, one in human prolactin and one in its receptor, are critical for pH-dependent receptor recognition and activation.Kulkarni MV, Tettamanzi MC, Murphy JW, Keeler C, Myszka DG, Chayen NE, Lolis EJ, Hodsdon ME. J Biol Chem. 2010 Dec 3; 2010 Sep 30. PMID: 20889499.
• Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.Cho Y, Crichlow GV, Vermeire JJ, Leng L, Du X, Hodsdon ME, Bucala R, Cappello M, Gross M, Gaeta F, Johnson K, Lolis EJ. Proc Natl Acad Sci U S A. 2010 Jun 22; 2010 Jun 8. PMID: 20534506.
• Heterologous quaternary structure of CXCL12 and its relationship to the CC chemokine family.Murphy JW, Yuan H, Kong Y, Xiong Y, Lolis EJ. Proteins. 2010 Apr. PMID: 20077567.
• Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.Crichlow GV, Lubetsky JB, Leng L, Bucala R, Lolis EJ. Biochemistry. 2009 Jan 13. PMID: 19090677.
• A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.Winner M, Meier J, Zierow S, Rendon BE, Crichlow GV, Riggs R, Bucala R, Leng L, Smith N, Lolis E, Trent JO, Mitchell RA. Cancer Res. 2008 Sep 15. PMID: 18794110.
• Orthologs of macrophage migration inhibitory factor from parasitic nematodes.Vermeire JJ, Cho Y, Lolis E, Bucala R, Cappello M. Trends Parasitol. 2008 Aug; 2008 Jul 4. PMID: 18603473.
• A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.Kamir D, Zierow S, Leng L, Cho Y, Diaz Y, Griffith J, McDonald C, Merk M, Mitchell RA, Trent J, Chen Y, Kwong YK, Xiong H, Vermeire J, Cappello M, McMahon-Pratt D, Walker J, Bernhagen J, Lolis E, Bucala R. J Immunol. 2008 Jun 15. PMID: 18523291.
• Structural and single-channel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating.Zhang W, Cho Y, Lolis E, Howe JR. J Neurosci. 2008 Jan 23. PMID: 18216201.
• Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition.Crichlow GV, Zhou H, Hsiao HH, Frederick KB, Debrosse M, Yang Y, Folta-Stogniew EJ, Chung HJ, Fan C, De la Cruz EM, Levens D, Lolis E, Braddock D. EMBO J. 2008 Jan 9; 2007 Dec 6. PMID: 18059478.
• Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74.Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M. J Biol Chem. 2007 Aug 10; 2007 Jun 13. PMID: 17567581.
• Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.Crichlow GV, Cheng KF, Dabideen D, Ochani M, Aljabari B, Pavlov VA, Miller EJ, Lolis E, Al-Abed Y. J Biol Chem. 2007 Aug 10; 2007 May 25. PMID: 17526494.
• Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin.Murphy JW, Cho Y, Sachpatzidis A, Fan C, Hodsdon ME, Lolis E. J Biol Chem. 2007 Mar 30; 2007 Jan 29. PMID: 17264079.
• CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.Shi X, Leng L, Wang T, Wang W, Du X, Li J, McDonald C, Chen Z, Murphy JW, Lolis E, Noble P, Knudson W, Bucala R. Immunity. 2006 Oct. PMID: 17045821.
• Macrophage migration inhibitory factor promotes intestinal tumorigenesis.Wilson JM, Coletta PL, Cuthbert RJ, Scott N, MacLennan K, Hawcroft G, Leng L, Lubetsky JB, Jin KK, Lolis E, Medina F, Brieva JA, Poulsom R, Markham AF, Bucala R, Hull MA. Gastroenterology. 2005 Nov. PMID: 16285950.
• Macrophage migration inhibitory factor: a critical component of autoimmune inflammatory diseases.Bucala R, Lolis E. Drug News Perspect. 2005 Sep. PMID: 16362080.
• Tertiary structure of thiopurine methyltransferase from Pseudomonas syringae, a bacterial orthologue of a polymorphic, drug-metabolizing enzyme.Scheuermann TH, Lolis E, Hodsdon ME. J Mol Biol. 2003 Oct 24. PMID: 14556746.
• Therapeutic approaches to innate immunity: severe sepsis and septic shock.Lolis E, Bucala R. Nat Rev Drug Discov. 2003 Aug. PMID: 12904813.
• Macrophage migration inhibitory factor.Lolis E, Bucala R. Expert Opin Ther Targets. 2003 Apr. PMID: 12667094.
• Identification of allosteric peptide agonists of CXCR4.Sachpatzidis A, Benton BK, Manfredi JP, Wang H, Hamilton A, Dohlman HG, Lolis E. J Biol Chem. 2003 Jan 10; 2002 Nov 3. PMID: 12417595.
• The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y. J Biol Chem. 2002 Jul 12; 2002 May 7. PMID: 11997397.
• Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.Dios A, Mitchell RA, Aljabari B, Lubetsky J, O'Connor K, Liao H, Senter PD, Manogue KR, Lolis E, Metz C, Bucala R, Callaway DJ, Al-Abed Y. J Med Chem. 2002 Jun 6. PMID: 12036350.
• PAK1 kinase is required for CXCL1-induced chemotaxis.Wang D, Sai J, Carter G, Sachpatzidis A, Lolis E, Richmond A. Biochemistry. 2002 Jun 4. PMID: 12033944.
• Aggregation of human wild-type and H27A-prolactin in cells and in solution: roles of Zn(2+), Cu(2+), and pH.Sankoorikal BJ, Zhu YL, Hodsdon ME, Lolis E, Dannies PS. Endocrinology. 2002 Apr. PMID: 11897686.
• Structure, function, and inhibition of chemokines.Fernandez EJ, Lolis E. Annu Rev Pharmacol Toxicol. 2002. PMID: 11807180.
• Glucocorticoid counter regulation: macrophage migration inhibitory factor as a target for drug discovery.Lolis E. Curr Opin Pharmacol. 2001 Dec. PMID: 11757824.
• Structural studies of chemokines that inhibit HIV-1 entry.Fernandez EJ, Lolis E. Antivir Chem Chemother. 2001. PMID: 11594687.
• Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation.Fernandez EJ, Wilken J, Thompson DA, Peiper SC, Lolis E. Biochemistry. 2000 Oct 24. PMID: 11041848.
• Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase.Sachpatzidis A, Dealwis C, Lubetsky JB, Liang PH, Anderson KS, Lolis E. Biochemistry. 1999 Sep 28. PMID: 10504236.
• Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E. Biochemistry. 1999 Jun 1. PMID: 10353846.
• Macrophage migration inhibitory factor: cytokine, hormone, or enzyme?Swope MD, Lolis E. Rev Physiol Biochem Pharmacol. 1999. PMID: 10453691.
• Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor.Swope M, Sun HW, Blake PR, Lolis E. EMBO J. 1998 Jul 1. PMID: 9649424.
• Macrophage migration inhibitory factor interactions with glutathione and S-hexylglutathione.Swope MD, Sun HW, Klockow B, Blake P, Lolis E. J Biol Chem. 1998 Jun 12. PMID: 9614090.
• Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor.Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E. Proc Natl Acad Sci U S A. 1998 Jun 9. PMID: 9618518.
• Functional and receptor binding characterization of recombinant murine macrophage inflammatory protein 2: sequence analysis and mutagenesis identify receptor binding epitopes.Jerva LF, Sullivan G, Lolis E. Protein Sci. 1997 Aug. PMID: 9260277.
• Crystal structure of macrophage migration inhibitory factor (MIF), a glucocorticoid-induced regulator of cytokine production, reveals a unique architecture.Lolis E, Bucala R. Proc Assoc Am Physicians. 1996 Nov. PMID: 8956364.
• The subunit structure of human macrophage migration inhibitory factor: evidence for a trimer.Sun HW, Swope M, Cinquina C, Bedarkar S, Bernhagen J, Bucala R, Lolis E. Protein Eng. 1996 Aug. PMID: 8875640.
• Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.Sun HW, Bernhagen J, Bucala R, Lolis E. Proc Natl Acad Sci U S A. 1996 May 28. PMID: 8643551.
• Salvaging recombinants from low-efficiency ligase reactions for more efficient subcloning.Sun HW, Lolis E. Biotechniques. 1995 Apr. PMID: 7598899.
• Preliminary crystallographic analysis of murine macrophage inflammatory protein 2.Lolis E, Sweet RM, Cousens LS, Tekamp-Olson P, Sherry BA, Cerami A. J Mol Biol. 1992 Jun 5. PMID: 1602491.
• Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis.Lolis E, Petsko GA. Biochemistry. 1990 Jul 17. PMID: 2204418.
• Structure of yeast triosephosphate isomerase at 1.9-A resolution.Lolis E, Alber T, Davenport RC, Rose D, Hartman FC, Petsko GA. Biochemistry. 1990 Jul 17. PMID: 2204417.
• Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis.Lolis E, Petsko GA. Annu Rev Biochem. 1990. PMID: 2197984.
• Crystallography and site-directed mutagenesis of yeast triosephosphate isomerase: what can we learn about catalysis from a "simple" enzyme?Alber TC, Davenport RC Jr, Giammona DA, Lolis E, Petsko GA, Ringe D. Cold Spring Harb Symp Quant Biol. 1987. PMID: 3331346.