Publications

Featured Publications

Immunological regulation of skeletal muscle adaptation to exercise
Langston P, Mathis D. Immunological regulation of skeletal muscle adaptation to exercise. Cell Metabolism 2024, 36: 1175-1183. PMID: 38670108, PMCID: PMC11153001, DOI: 10.1016/j.cmet.2024.04.001.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise
Langston P, Sun Y, Ryback B, Mueller A, Spiegelman B, Benoist C, Mathis D. Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise. Science Immunology 2023, 8: eadi5377-eadi5377. PMID: 37922340, PMCID: PMC10860652, DOI: 10.1126/sciimmunol.adi5377.
Peer-Reviewed Original Research
MeSH Keywords

2026

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells
A M, Wang G, Zammit N, Roth L, Maierhaba Y, Bogoslavski D, Cai C, Langston P, Zhang Q, Afonina I, Beyaert R, Spiegelman B, Mathis D. Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells. Nature Metabolism 2026, 8: 885-901. PMID: 41933175, PMCID: PMC13052164, DOI: 10.1038/s42255-026-01491-2.
Peer-Reviewed Original Research
MeSH Keywords
Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging
Langston P, Vijaya Raghavan J, Benoist C, Mathis D. Piezo1-dependent activation of stromal cells ignites muscle inflammation in exercise and injury and is associated with inflammaging. Nature Immunology 2026, 27: 543-555. PMID: 41775886, PMCID: PMC13007780, DOI: 10.1038/s41590-026-02435-4.
Peer-Reviewed Original Research
MeSH Keywords
Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis
Hanna B, Langston P, Marin-Rodero M, Ramirez R, Wan M, Benoist C, Mathis D. Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2536314123. PMID: 41701829, PMCID: PMC12933153, DOI: 10.1073/pnas.2536314123.
Peer-Reviewed Original Research
MeSH Keywords

2025

Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes
Zammit N, Vargas-Castillo A, Langston P, Wang G, Zhou Y, Spiegelman B, Benoist C, Mathis D. Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes. Science Immunology 2025, 10: eads0478-eads0478. PMID: 40712046, PMCID: PMC12363373, DOI: 10.1126/sciimmunol.ads0478.
Peer-Reviewed Original Research
MeSH Keywords

2023

Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation
Petnicki-Ocwieja T, McCarthy J, Powale U, Langston P, Helble J, Hu L. Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation. PLOS Pathogens 2023, 19: e1011886. PMID: 38157387, PMCID: PMC10783791, DOI: 10.1371/journal.ppat.1011886.
Peer-Reviewed Original Research
MeSH Keywords
A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue
Yaghi O, Hanna B, Langston P, Michelson D, Jayewickreme T, Marin-Rodero M, Benoist C, Mathis D. A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue. Nature Immunology 2023, 24: 2053-2067. PMID: 37932455, PMCID: PMC10792729, DOI: 10.1038/s41590-023-01669-w.
Peer-Reviewed Original Research
MeSH Keywords
Spatial enrichment of the type 1 interferon signature in the brain of a neuropsychiatric lupus murine model
Aw E, Zhang Y, Yalcin E, Herrmann U, Lin S, Langston K, Castrillon C, Ma M, Moffitt J, Carroll M. Spatial enrichment of the type 1 interferon signature in the brain of a neuropsychiatric lupus murine model. Brain Behavior And Immunity 2023, 114: 511-522. PMID: 37369340, PMCID: PMC10918751, DOI: 10.1016/j.bbi.2023.06.021.
Peer-Reviewed Original Research
MeSH Keywords

2022

Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis
Xiao T, Langston P, Muñoz-Rojas A, Jayewickreme T, Lazar M, Benoist C, Mathis D. Tregs in visceral adipose tissue up-regulate circadian-clock expression to promote fitness and enforce a diurnal rhythm of lipolysis. Science Immunology 2022, 7: eabl7641-eabl7641. PMID: 36179011, PMCID: PMC9769829, DOI: 10.1126/sciimmunol.abl7641.
Peer-Reviewed Original Research
MeSH Keywords
The potential for Treg-enhancing therapies in tissue, in particular skeletal muscle, regeneration
Hanna B, Yaghi O, Langston P, Mathis D. The potential for Treg-enhancing therapies in tissue, in particular skeletal muscle, regeneration. Clinical & Experimental Immunology 2022, 211: 138-148. PMID: 35972909, PMCID: PMC10019136, DOI: 10.1093/cei/uxac076.
Peer-Reviewed Original Research
MeSH Keywords

2021

Down-Regulation of a Profibrotic Transforming Growth Factor-β1/Cellular Communication Network Factor 2/Matrix Metalloprotease 9 Axis by Triamcinolone Improves Idiopathic Subglottic Stenosis
Treviño-Villarreal J, Reynolds J, Langston P, Thompson A, Mitchell J, Franco R. Down-Regulation of a Profibrotic Transforming Growth Factor-β1/Cellular Communication Network Factor 2/Matrix Metalloprotease 9 Axis by Triamcinolone Improves Idiopathic Subglottic Stenosis. American Journal Of Pathology 2021, 191: 1412-1430. PMID: 34111429, DOI: 10.1016/j.ajpath.2021.05.013.
Peer-Reviewed Original Research
MeSH Keywords

2020

High-intensity ultrasound irradiation promotes the release of extracellular vesicles from C2C12 myotubes
Maeshige N, Langston P, Yuan Z, Kondo H, Fujino H. High-intensity ultrasound irradiation promotes the release of extracellular vesicles from C2C12 myotubes. Ultrasonics 2020, 110: 106243. PMID: 32961400, DOI: 10.1016/j.ultras.2020.106243.
Peer-Reviewed Original Research
MeSH Keywords

2019

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nature Immunology 2019, 20: 1186-1195. PMID: 31384058, PMCID: PMC6707851, DOI: 10.1038/s41590-019-0453-7.
Peer-Reviewed Original Research
MeSH Keywords

2018

Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and –independent mechanisms
Treviño-Villarreal J, Reynolds J, Bartelt A, Langston P, MacArthur M, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace L, Mejia P, Trocha K, Kajitani G, Longchamp A, Harputlugil E, Gathungu R, Bird S, Bullock A, Figenshau R, Andriole G, Thompson A, Heeren J, Ozaki C, Kristal B, Fontana L, Mitchell J. Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and –independent mechanisms. JCI Insight 2018, 3: e99470. PMID: 30385734, PMCID: PMC6238732, DOI: 10.1172/jci.insight.99470.
Peer-Reviewed Original Research
MeSH Keywords

2017

Metabolism Supports Macrophage Activation
Langston P, Shibata M, Horng T. Metabolism Supports Macrophage Activation. Frontiers In Immunology 2017, 8: 61. PMID: 28197151, PMCID: PMC5281575, DOI: 10.3389/fimmu.2017.00061.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

2014

Gammaherpesvirus Latency Differentially Impacts the Generation of Primary versus Secondary Memory CD8+ T Cells during Subsequent Infection
Barton E, Rajkarnikar S, Langston P, Price M, Grayson J. Gammaherpesvirus Latency Differentially Impacts the Generation of Primary versus Secondary Memory CD8+ T Cells during Subsequent Infection. Journal Of Virology 2014, 88: 12740-12751. PMID: 25142586, PMCID: PMC4248948, DOI: 10.1128/jvi.02106-14.
Peer-Reviewed Original Research
MeSH Keywords

2013

Increased Cell Surface Free Thiols Identify Effector CD8+ T Cells Undergoing T Cell Receptor Stimulation
Pellom S, Michalek R, Crump K, Langston P, Juneau D, Grayson J. Increased Cell Surface Free Thiols Identify Effector CD8+ T Cells Undergoing T Cell Receptor Stimulation. PLOS ONE 2013, 8: e81134. PMID: 24236211, PMCID: PMC3827480, DOI: 10.1371/journal.pone.0081134.
Peer-Reviewed Original Research
MeSH Keywords

2012

Antioxidant Treatment Regulates the Humoral Immune Response during Acute Viral Infection
Crump K, Langston P, Rajkarnikar S, Grayson J. Antioxidant Treatment Regulates the Humoral Immune Response during Acute Viral Infection. Journal Of Virology 2012, 87: 2577-2586. PMID: 23255789, PMCID: PMC3571411, DOI: 10.1128/jvi.02714-12.
Peer-Reviewed Original Research
MeSH Keywords