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Selected Publications

Hematopoiesis/Leukemogenesis

  • Kwon N, Thompson EN, Mayday MY, Scanlon V, Lu YC, Krause DS. Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants. Curr Opin Hematol. 2021 Jan;28(1):28-35. doi: 10.1097/MOH.0000000000000625. PMID: 33186151
  • Reed F, Larsuel ST, Mayday MY, Scanlon V, Krause DS.MRTFA: a critical protein in normal and malignant hematopoiesis and beyond. J Biol Chem. 2021 Mar 12:100543. doi: 10.1016/j.jbc.2021.100543. PMID: 33722605
  • Xavier-Ferrucio J, Scanlon VM, Li X, Zhang P-X, Lozovatsky L, Ayala-Lopez N, Tebaldi T, Halene S, Cao C, Fleming MD, Finberg KE, Krause DS. Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice. Blood. 2019 Oct 31;134(18):1547-1557. doi: 10.1182/blood.2019002039.
  • Scanlon VM, Teixeira AM, Tyagi T, Zou S, Zhang PX, Booth CJ, Kowalska MA, Bao J, Hwa J, Hayes V, Marks MS, Poncz M, Krause DS. Epithelial (E)-Cadherin is a novel mediator of platelet aggregation and clot stability. Thromb Haemost. 2019 Mar 12. doi: 10.1055/s-0039-1679908.
  • Lu Y-C, Xavier-Ferrucio J, Wang L, Zhang P-X, Grimes L, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS. (2018). The molecular signature of megakaryocyte-erythroid progenitors reveals a role for the cell cycle in fate specification. Cell Reports, 25(8), 2083-2093. PMID: 30463007
  • Jin H, Ciechanowicz AK, Kaplan AR, Wang L, Zhang P-X, Lu YC, Tobin RE, Tobin BA, Cohn L, Zeiss CJ, Lee PJ, Bruscia EM, Krause DS. (2018). Surfactant Protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. American Journal of Physiology-Lung Cellular and Molecular Physiology, 314:L882-L892. PMID: 29345196
  • Rahman N, Schulz VP, Wang L, Gallagher PG, Denisenko O, Gualdrini F, Esnault C, Krause DS. (2018). MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis. Blood Advances, 2(20): 2691-2703. PMID: 30337297
  • Zou S, Teixeira AM, Kostadima M, Astle WJ, Radhakrishnan A, Simon LM, Truman L, Fang JS, Hwa J, Zhang PX, van der Harst P, Bray PF, Ouwehand WH, Frontini M, Krause DS. (2017). SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume. PLoS One, 12(5): e0178095. PMID: 5441597.
  • Sanada C, Xavier-Ferrucio J, Lu Y-C, Min E, Zhang P-X, Zou S, Kang E, Zhang M, Zerafati G, Gallagher PG, Krause DS. (2016). Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction. Blood, 128:923-933. PMID: 27268089
  • Guo S, Zi X, Schulz V, Cheng J, Zhong M, Koochaki SHJ, Megyola CM, Pan X, Heydari K, Weissman SM, Gallagher PG, Krause DS, Fan R, Lu J. (2014). Non-stochastic reprogramming from a privileged somatic cell state. Cell, 156:649-662. PMID: 24486105
  • Smith EC, Teixeira AM, Chen RC, Wang L, Gao Y, Hahn KL, Krause DS. (2013). Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation. Blood, 121: 1094-1101. PMID: 23243284
  • Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Gao Y, Massaro SA, Halene S, Lu J, Gallagher P, Italiano JE, Krause DS. (2012). MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood, 120:2317-2329. PMID: 22806889
  • Gao Y, Smith E, Ker E, Campbell P, Cheng E, Zou S, Lin S, Wang L, Halene S, Krause DS. (2012). Role of RhoA specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Developmental Cell. 22(3): 573-587 PMID: 22387001
  • Massaro SA, Bajaj R, Pashankar FD, Ornstein D, Gallagher PG, Krause DS, Li P. (2011). Bi-allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia. Pediatr Blood Cancer. 57:516-519. PMID 21593379.
  • Bruscia EM, Zhang P, Satoh A, Caputo C, Medzhitov R, Shenoy A, Egan ME, Krause DS. (2011). Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunology 186: 6990-98. PMID: 21593379
  • Halene S, Gao Y, Hahn K, Massaro S, Italiano JE, Lin S, Kupfer GM, Krause DS. (2010). Serum Response Factor is an essential transcription factor in megakaryocytic maturation. Blood 116:1942-1950. PMID: 20525922
  • Cheng EC, Luo Q, Bruscia EM, Renda MJ, Troy JA, Massaro SA, Tuck D, Schulz V, Mane SM, Berliner N, Sun Y, Morris SW, Qiu C, Krause DS. (2009). Role for MKL1 in megakaryocytic maturation. Blood: 113:2826-34.
  • Ma X, Renda M, Wang L, Cheng E, Niu C, Morris S, Chi AS, Krause DS. (2007). Rbm15 Modulates Notch-induced Transcriptional Activation and Affects Myeloid Differentiation. MCB, 27-8: 3056-3064.
  • Ma Y, Cui W, Yang J, Qu J, Di C, Amin HM, Lai R, Ritz J, Krause DS, Chai L. (2006). SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice. Blood 108: 2726-35.
  • Ma X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, and Perkins AS. (2002). Development of a murine hematopoietic progenitor cDNA microarray using a subtracted cDNA library. Blood 100:833-44.

Differentiation of Pluripotent Stem Cells into Functional Parathyroid Cells

Differentiation of Marrow Derived Cells into Epithelial Cells


  • Kassmer SH, Jin H, Zhang P-X, Bruscia EM, Heydari K, Lee J-H, Kim CF, Krause DS. (2013). Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung. Stem Cells. 31(12):2759-2766. PMID: 23681901
  • Kassmer SH, Bruscia EM, Zhang PX, Krause DS. (2012). Non-Hematopoietic cells are the primary source of bone marrow derived lung epithelial cells. Stem Cells 30, 491-499. PMID:22162244
  • Kassmer SH, Krause DS. (2010). Detection of bone marrow-derived lung epithelial cells. Exp Hematol. 38:564-573. PMID: 20447442
  • Swenson ES, Guest I, Ilic Z, Mazzeo M, Lizardi P, Hardiman C, Sell S, Krause DS. (2008). Hepatocyte Nuclear Factor-1 as marker of epithelial phenotype reveals marrow-derived hepatocytes, but not duct cells, after liver injury in mice. Stem Cells.26:1768-1777. PMID: 18467658
  • Bruscia EM, Ziegler EC, Price JE, Weiner S, Egan ME, Krause DS. (2006). Engraftment of donor derived epithelial cells in multiple organs following bone marrow transplantation into newborn mice. Stem Cells 24: 2299-2308. PMID: 16794262
  • Herzog EL, Van Arnam J, Hu B, Krause DS. (2006). Threshold of lung injury required for the appearance of marrow-derived lung epithelia. Stem Cells 24: 1986-1992. PMID: 16868209
  • Bruscia E, Price J, Cheng E, Weiner S, Caputo C, Ferreira E, Egan ME, Krause DS. (2006). Assessment of cystic fibrosis transmembrane conductance regulator (CFTR) activity in CFTR-null mice following bone marrow transplantation. PNAS 103: 2965-70.
  • Borue X, Lee S, Grove JE, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise N, Krause DS. (2004). Bone marrow derived stem cells are recruited to wounded skin, and contribute to epithelial engraftment during wound healing. Am. Journal of Pathology 165: 1767-72.
  • Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. (2004). Lack of a fusion requirement for development of bone marrow derived epithelia. Science 305: 90.
  • Grove JE, Lutzko C, Priller J, Henegariu O, Theise ND, Kohn DB, Krause DS. (2002). Marrow-derived cells as vehicles for delivery of gene-therapy to pulmonary epithelium,American Journal of Respiratory Cell and Molecular Biology 27: 645-651.
  • Theise ND, Henegariu O, Grove JE, Jagirdar J, Kao PN, Crawford JM, Badve S, Saxena R, Krause DS. (2002). Radiation Pneumonitis in Mice: A Severe Injury Model for Pneumocyte Engraftment from Bone Marrow, Experimental Hematology; 30:1333-1338.
  • Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-77.
  • Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS. (2000). Liver from bone marrow in humans. Hepatology, 32: 11-16.
  • Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. (2000). Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology, 31: 235-240.