Publications
PubMed Publications
2023
- Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis Throughout the Day.Malik DM, Rhoades SD, Zhang SL, Sengupta A, Barber A, Haynes P, Arnadottir ES, Pack A, Kibbey RG, Sehgal A, Weljie AM. bioRxiv. 2023 Nov 2; 2023 Nov 2. PMID: 37961230.
- ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control.Gao Y, Zimmer JT, Vasic R, Liu C, Gbyli R, Zheng SJ, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao AZ, Slavoff S, Kibbey RG, Flavell RA, Simon MD, Tebaldi T, Li HB, Halene S. Cell Rep. 2023 Oct 31; 2023 Sep 23. PMID: 37742191.
- TNFα increases the degradation of pyruvate dehydrogenase kinase 4 by the Lon protease to support proinflammatory genes.Boutagy NE, Fowler JW, Grabinska KA, Cardone R, Sun Q, Vazquez KR, Whalen MB, Zhu X, Chakraborty R, Martin KA, Simons M, Romanoski CE, Kibbey RG, Sessa WC. Proc Natl Acad Sci U S A. 2023 Sep 19; 2023 Sep 11. PMID: 37695914.
- Loss of ZNF148 enhances insulin secretion in human pancreatic β cells.de Klerk E, Xiao Y, Emfinger CH, Keller MP, Berrios DI, Loconte V, Ekman AA, White KL, Cardone RL, Kibbey RG, Attie AD, Hebrok M. JCI Insight. 2023 Jun 8; 2023 Jun 8. PMID: 37288664.
- Ketones: the double-edged sword of SGLT2 inhibitors?Lupsa BC, Kibbey RG, Inzucchi SE. Diabetologia. 2023 Jan; 2022 Oct 18. PMID: 36255460.
- Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo.Codella R, Alves TC, Befroy DE, Choi CS, Luzi L, Rothman DL, Kibbey RG, Shulman GI. FEBS Lett. 2023 Jan; 2022 Sep 27. PMID: 36114012.
2022
- Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes.Yang ML, Kibbey RG, Mamula MJ. Front Immunol. 2022; 2022 Oct 27. PMID: 36389721.
- β-cell deletion of the PKm1 and PKm2 isoforms of pyruvate kinase in mice reveals their essential role as nutrient sensors for the K(ATP) channel.Foster HR, Ho T, Potapenko E, Sdao SM, Huang SM, Lewandowski SL, VanDeusen HR, Davidson SM, Cardone RL, Prentki M, Kibbey RG, Merrins MJ. Elife. 2022 Aug 23; 2022 Aug 23. PMID: 35997256.
- Metabolic cycles and signals for insulin secretion.Merrins MJ, Corkey BE, Kibbey RG, Prentki M. Cell Metab. 2022 Jul 5; 2022 Jun 20. PMID: 35728586.
- β Cell-specific deletion of Zfp148 improves nutrient-stimulated β cell Ca2+ responses.Emfinger CH, de Klerk E, Schueler KL, Rabaglia ME, Stapleton DS, Simonett SP, Mitok KA, Wang Z, Liu X, Paulo JA, Yu Q, Cardone RL, Foster HR, Lewandowski SL, Perales JC, Kendziorski CM, Gygi SP, Kibbey RG, Keller MP, Hebrok M, Merrins MJ, Attie AD. JCI Insight. 2022 May 23; 2022 May 23. PMID: 35603790.
- Citrullination of glucokinase is linked to autoimmune diabetes.Yang ML, Horstman S, Gee R, Guyer P, Lam TT, Kanyo J, Perdigoto AL, Speake C, Greenbaum CJ, Callebaut A, Overbergh L, Kibbey RG, Herold KC, James EA, Mamula MJ. Nat Commun. 2022 Apr 6; 2022 Apr 6. PMID: 35388005.
- Dyrk1b promotes hepatic lipogenesis by bypassing canonical insulin signaling and directly activating mTORC2 in mice.Bhat N, Narayanan A, Fathzadeh M, Kahn M, Zhang D, Goedeke L, Neogi A, Cardone RL, Kibbey RG, Fernandez-Hernando C, Ginsberg HN, Jain D, Shulman GI, Mani A. J Clin Invest. 2022 Feb 1. PMID: 34855620.
2021
- Development of a Bioartificial Vascular Pancreas.Han EX, Wang J, Kural M, Jiang B, Leiby KL, Chowdhury N, Tellides G, Kibbey RG, Lawson JH, Niklason LE. J Tissue Eng. 2021 Jan-Dec; 2021 Jun 28. PMID: 34262686.
- Mitochondrial Fission Governed by Drp1 Regulates Exogenous Fatty Acid Usage and Storage in Hela Cells.Song JE, Alves TC, Stutz B, Šestan-Peša M, Kilian N, Jin S, Diano S, Kibbey RG, Horvath TL. Metabolites. 2021 May 18; 2021 May 18. PMID: 34069800.
2020
- NLRX1 Deletion Increases Ischemia-Reperfusion Damage and Activates Glucose Metabolism in Mouse Heart.Zhang H, Xiao Y, Nederlof R, Bakker D, Zhang P, Girardin SE, Hollmann MW, Weber NC, Houten SM, van Weeghel M, Kibbey RG, Zuurbier CJ. Front Immunol. 2020; 2020 Dec 11. PMID: 33362773.
- Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health.Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG. Cell Metab. 2020 Nov 3. PMID: 33147485.
- Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway.Lewandowski SL, Cardone RL, Foster HR, Ho T, Potapenko E, Poudel C, VanDeusen HR, Sdao SM, Alves TC, Zhao X, Capozzi ME, de Souza AH, Jahan I, Thomas CJ, Nunemaker CS, Davis DB, Campbell JE, Kibbey RG, Merrins MJ. Cell Metab. 2020 Nov 3. PMID: 33147484.
- Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.Chung KM, Singh J, Lawres L, Dorans KJ, Garcia C, Burkhardt DB, Robbins R, Bhutkar A, Cardone R, Zhao X, Babic A, Vayrynen SA, Dias Costa A, Nowak JA, Chang DT, Dunne RF, Hezel AF, Koong AC, Wilhelm JJ, Bellin MD, Nylander V, Gloyn AL, McCarthy MI, Kibbey RG, Krishnaswamy S, Wolpin BM, Jacks T, Fuchs CS, Muzumdar MD. Cell. 2020 May 14; 2020 Apr 17. PMID: 32304665.
- Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis.Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA. Cell Rep. 2020 May 12. PMID: 32402282.
- Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels.Taddeo EP, Alsabeeh N, Baghdasarian S, Wikstrom JD, Ritou E, Sereda S, Erion K, Li J, Stiles L, Abdulla M, Swanson Z, Wilhelm JJ, Bellin MD, Kibbey RG, Liesa M, Shirihai OS. Diabetes. 2020 Feb; 2019 Nov 18. PMID: 31740442.
- Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood.Bendor CD, Bardugo A, Zucker I, Cukierman-Yaffe T, Lutski M, Derazne E, Shohat T, Mosenzon O, Tzur D, Sapir A, Pinhas-Hamiel O, Kibbey RG, Raz I, Afek A, Gerstein HC, Tirosh A, Twig G. Diabetes Care. 2020 Jan; 2019 Nov 6. PMID: 31694859.
2019
- Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd ET, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Kshitiz, Aerni HR, Gross S, Kung C, Samuel VT, Shulman GI, Kibbey RG, Rinehart J. Cell Rep. 2019 Dec 10. PMID: 31825824.
- N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis.Grevengoed TJ, Trammell SAJ, McKinney MK, Petersen N, Cardone RL, Svenningsen JS, Ogasawara D, Nexøe-Larsen CC, Knop FK, Schwartz TW, Kibbey RG, Cravatt BF, Gillum MP. Proc Natl Acad Sci U S A. 2019 Dec 3; 2019 Nov 18. PMID: 31740614.
- CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.Esteghamat F, Broughton JS, Smith E, Cardone R, Tyagi T, Guerra M, Szabó A, Ugwu N, Mani MV, Azari B, Kayingo G, Chung S, Fathzadeh M, Weiss E, Bender J, Mane S, Lifton RP, Adeniran A, Nathanson MH, Gorelick FS, Hwa J, Sahin-Tóth M, Belfort-DeAguiar R, Kibbey RG, Mani A. Nat Genet. 2019 Aug; 2019 Jul 29. PMID: 31358993.
- Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos.Jesinkey SR, Madiraju AK, Alves TC, Yarborough OH, Cardone RL, Zhao X, Parsaei Y, Nasiri AR, Butrico G, Liu X, Molina AJ, Rountree AM, Neal AS, Wolf DM, Sterpka J, Philbrick WM, Sweet IR, Shirihai OH, Kibbey RG. Cell Rep. 2019 Jul 16. PMID: 31315053.
- Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.Perry RJ, Rabin-Court A, Song JD, Cardone RL, Wang Y, Kibbey RG, Shulman GI. Nat Commun. 2019 Feb 1; 2019 Feb 1. PMID: 30710078.
2018
- Insulin Regulates Glycogen Synthesis in Human Endometrial Glands Through Increased GYS2.Flannery CA, Choe GH, Cooke KM, Fleming AG, Radford CC, Kodaman PH, Jurczak MJ, Kibbey RG, Taylor HS. J Clin Endocrinol Metab. 2018 Aug 1. PMID: 29726999.
- Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis.Ouyang X, Han SN, Zhang JY, Dioletis E, Nemeth BT, Pacher P, Feng D, Bataller R, Cabezas J, Stärkel P, Caballeria J, Pongratz RL, Cai SY, Schnabl B, Hoque R, Chen Y, Yang WH, Garcia-Martinez I, Wang FS, Gao B, Torok NJ, Kibbey RG, Mehal WZ. Cell Metab. 2018 Feb 6. PMID: 29414684.
- Metabolic Analysis of Lymphatic Endothelial Cells.Yu P, Alves TC, Kibbey RG, Simons M. Methods Mol Biol. 2018. PMID: 30242770.
- SGLT2 knockout prevents hyperglycemia and is associated with reduced pancreatic β-cell death in genetically obese mice.Jurczak MJ, Saini S, Ioja S, Costa DK, Udeh N, Zhao X, Whaley JM, Kibbey RG. Islets. 2018; 2018 Aug 17. PMID: 30118626.
2017
- Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Proc Natl Acad Sci U S A. 2017 Oct 24; 2017 Oct 10. PMID: 29073114.
- Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis.Foer D, Zhu M, Cardone RL, Simpson C, Sullivan R, Nemiroff S, Lee G, Kibbey RG, Petersen KF, Insogna KL. Osteoporos Int. 2017 Jun; 2017 Mar 10. PMID: 28283687.
- FGF-dependent metabolic control of vascular development.Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. Nature. 2017 May 11; 2017 May 3. PMID: 28467822.
2016
- Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.Perry RJ, Cardone RL, Petersen MC, Zhang D, Fouqueray P, Hallakou-Bozec S, Bolze S, Shulman GI, Petersen KF, Kibbey RG. Am J Physiol Endocrinol Metab. 2016 Aug 1; 2016 Jul 12. PMID: 27406738.
- Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism.Madiraju AK, Alves T, Zhao X, Cline GW, Zhang D, Bhanot S, Samuel VT, Kibbey RG, Shulman GI. Proc Natl Acad Sci U S A. 2016 Jun 14; 2016 May 31. PMID: 27247419.
- Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome.Perry RJ, Peng L, Barry NA, Cline GW, Zhang D, Cardone RL, Petersen KF, Kibbey RG, Goodman AL, Shulman GI. Nature. 2016 Jun 9. PMID: 27279214.
- Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism.Perry RJ, Borders CB, Cline GW, Zhang XM, Alves TC, Petersen KF, Rothman DL, Kibbey RG, Shulman GI. J Biol Chem. 2016 Jun 3; 2016 Mar 21. PMID: 27002151.
2015
- Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle.Alves TC, Pongratz RL, Zhao X, Yarborough O, Sereda S, Shirihai O, Cline GW, Mason G, Kibbey RG. Cell Metab. 2015 Nov 3; 2015 Sep 24. PMID: 26411341.
- Effect of aging on muscle mitochondrial substrate utilization in humans.Petersen KF, Morino K, Alves TC, Kibbey RG, Dufour S, Sono S, Yoo PS, Cline GW, Shulman GI. Proc Natl Acad Sci U S A. 2015 Sep 8; 2015 Aug 24. PMID: 26305973.
- A roadmap for interpreting (13)C metabolite labeling patterns from cells.Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. Curr Opin Biotechnol. 2015 Aug; 2015 Feb 28. PMID: 25731751.
- SGLT-2 inhibition and glucagon: Cause for alarm?Kibbey RG. Trends Endocrinol Metab. 2015 Jul; 2015 Jun 6. PMID: 26059706.
- Response to burgess.Befroy DE, Kibbey RG, Perry RJ, Petersen KF, Rothman DL, Shulman GI. Nat Med. 2015 Feb. PMID: 25654597.
2014
- Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.Kibbey RG, Choi CS, Lee HY, Cabrera O, Pongratz RL, Zhao X, Birkenfeld AL, Li C, Berggren PO, Stanley C, Shulman GI. Diabetes. 2014 Dec; 2014 Jul 14. PMID: 25024374.
- Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.Kim JD, Toda C, D'Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Proc Natl Acad Sci U S A. 2014 Aug 12; 2014 Jul 28. PMID: 25071172.
- Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase.Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI. Nature. 2014 Jun 26; 2014 May 21. PMID: 24847880.
- The mitochondrial isoform of phosphoenolpyruvate carboxykinase (PEPCK-M) and glucose homeostasis: has it been overlooked?Stark R, Kibbey RG. Biochim Biophys Acta. 2014 Apr; 2013 Oct 28. PMID: 24177027.
2011
- Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats.Jamison RA, Stark R, Dong J, Yonemitsu S, Zhang D, Shulman GI, Kibbey RG. Am J Physiol Endocrinol Metab. 2011 Dec; 2011 Aug 23. PMID: 21862723.
- Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance.Alves TC, Befroy DE, Kibbey RG, Kahn M, Codella R, Carvalho RA, Falk Petersen K, Shulman GI. Hepatology. 2011 Apr; 2011 Mar 11. PMID: 21400553.
- SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function.Jurczak MJ, Lee HY, Birkenfeld AL, Jornayvaz FR, Frederick DW, Pongratz RL, Zhao X, Moeckel GW, Samuel VT, Whaley JM, Shulman GI, Kibbey RG. Diabetes. 2011 Mar. PMID: 21357472.
2009
- Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion.Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG. J Biol Chem. 2009 Sep 25; 2009 Jul 27. PMID: 19635791.
- Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. J Biol Chem. 2009 Jun 19; 2009 Apr 17. PMID: 19376774.
- Investigating the roles of mitochondrial and cytosolic malic enzyme in insulin secretion.Pongratz RL, Kibbey RG, Cline GW. Methods Enzymol. 2009. PMID: 19426882.
2007
- Mitochondrial GTP regulates glucose-stimulated insulin secretion.Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI. Cell Metab. 2007 Apr. PMID: 17403370.
- Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion.Pongratz RL, Kibbey RG, Shulman GI, Cline GW. J Biol Chem. 2007 Jan 5; 2006 Nov 13. PMID: 17102138.
2004
- 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells.Cline GW, Lepine RL, Papas KK, Kibbey RG, Shulman GI. J Biol Chem. 2004 Oct 22; 2004 Aug 9. PMID: 15304488.