Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study
Ni W, Breitner S, Nikolaou N, Wolf K, Zhang S, Peters A, Herder C, Schneider A. Effects of Short- And Medium-Term Exposures to Lower Air Temperature on 71 Novel Biomarkers of Subclinical Inflammation: Results from the KORA F4 Study. Environmental Science And Technology 2023, 57: 12210-12221. PMID: 37552838, PMCID: PMC10448716, DOI: 10.1021/acs.est.3c00302.Peer-Reviewed Original ResearchConceptsKORA F4 studyBiomarkers of subclinical inflammationHigher risk of chronic diseasesF4 studyLevels of air pollutionLow air temperatureRisk of chronic diseasesPopulation-based KORA F4 studyCross-sectional analysisSubclinical inflammationAdverse health effectsCumulative lagAssociated with higher levelsAir pollutionAir temperatureChronic diseasesNeurotrophin-3Older participantsInterleukin-6Additive modelMedium-term effectsProximity extension assay technologyHealth effectsCardiovascular diseaseHigh riskAssociations between medium- and long-term exposure to air temperature and epigenetic age acceleration
Ni W, Nikolaou N, Ward-Caviness C, Breitner S, Wolf K, Zhang S, Wilson R, Waldenberger M, Peters A, Schneider A. Associations between medium- and long-term exposure to air temperature and epigenetic age acceleration. Environment International 2023, 178: 108109. PMID: 37517177, PMCID: PMC10656697, DOI: 10.1016/j.envint.2023.108109.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationGeneralized estimating equationsExposure to high air temperaturesAge accelerationAverage air temperatureDistributed lag non-linear modelMeasures of epigenetic age accelerationAir temperatureHuman health worldwideExposure to air temperaturesSpatial variationClimate changeEffects of air temperatureAnnual average temperatureKORA F4PhenoAge accelerationHigh air temperatureGrimAge accelerationHannumAAGrimAAEstimating equationsAging populationHorvathAA