Siqi Zhang
Associate Research ScientistCards
About
Research
Publications
2026
Sex-specific associations between long-term exposure to ambient air pollution and the cardiac conduction system - a longitudinal analysis of the KORA cohort
Li Y, Zhang S, Diaz-Sanchez D, Wolf K, Rückert-Eheberg I, Kääb S, Schmidt G, Strom A, Peters A, Schneider A, Breitner-Busch S. Sex-specific associations between long-term exposure to ambient air pollution and the cardiac conduction system - a longitudinal analysis of the KORA cohort. International Journal Of Hygiene And Environmental Health 2026, 276: 114850. PMID: 42275869, DOI: 10.1016/j.ijheh.2026.114850.Peer-Reviewed Original ResearchLong-term exposure to ambient air pollutionExposure to ambient air pollutionAmbient air pollutionAir pollutionLong-term air pollution exposureInterquartile rangeLand-use regression modelsExposure to cardiovascular diseaseLower educational attainmentAir pollution exposureExposure to nitrogen dioxideSex-stratified analysesSex-specific associationsChronic air pollutionChronic exposure effectsHeart rateEffect modificationKORA cohortStratified analysisKORA S4Pollution exposureParticulate matterLand-useEducational attainmentParticle number concentrationUpward Air Temperature Shifts and Acute Cardiovascular Events in Individuals with Atherosclerotic Cardiovascular Disease: A Time-Stratified Case-Crossover Study
Lechner K, Zhang S, Krüger N, Krefting J, Wolf K, Dallavalle M, Dreischulte T, Offenborn F, Starnecker F, von Scheidt M, Chen K, Peters A, Breitner S, Schneider A, Schunkert H. Upward Air Temperature Shifts and Acute Cardiovascular Events in Individuals with Atherosclerotic Cardiovascular Disease: A Time-Stratified Case-Crossover Study. The Lancet Regional Health - Europe 2026, 67: 101730. PMID: 42294354, PMCID: PMC13262291, DOI: 10.1016/j.lanepe.2026.101730.Peer-Reviewed Original ResearchCase-crossover studyAssociated with higher riskAtherosclerotic cardiovascular diseaseAll-Cause MortalityAcute cardiovascular eventsBavarian State MinistryHealth impactsPublic health actionTime-varying confoundersCardiovascular diseaseConditional Poisson regressionGerman health insuranceRisk of ACArea-specific estimatesCase-crossoverHealth actionsPoisson regressionHeart FoundationCardiovascular eventsMultivariate meta-analysisPostcode levelHealth impacts of heatHealth insuranceHealth—andHealth concernLow-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults
Zhang Y, Zhang S, Wang Y, Spatz E, Krumholz H, Lu Y, Chen K. Low-Level Airborne Particulate Matter and Risk of Hypertension Hospitalization in Older U.S. Adults. Journal Of The American College Of Cardiology 2026, 87: 2826-2842. PMID: 41984014, DOI: 10.1016/j.jacc.2026.02.5112.Peer-Reviewed Original ResearchConceptsAnnual PM2.5 concentrationsEffects of PM2.5Quasi-Poisson regression modelParticulate matterExposure to PM2.5 concentrationsLong-term exposure to fine particulate matterExposure to fine particulate matterFine particulate matterAir quality standardsAirborne particulate matterAnnual standardRegulatory thresholdsQuality standardsContiguous United StatesHypertension hospitalizationsSuburban areasSocioeconomically deprived neighborhoodsOlder U.S. adultsRegulatory standardsRegression modelsConcentrationDeprived neighbourhoodsEffect modificationGreater vulnerabilityOlder adultsImpact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States A Population-Based Cohort Study
Zhang S, Wang Y, Wei J, Benmarhnia T, Liu Y, Krumholz H, Lu Y, Chen K. Impact of Long-Term Cumulative Exposure to Wildfire Smoke PM2.5 on Cardiovascular Hospital Admissions Among Older Adults in the United States A Population-Based Cohort Study. Journal Of The American College Of Cardiology 2026 PMID: 41706074, DOI: 10.1016/j.jacc.2025.12.079.Peer-Reviewed Original ResearchThis study investigates how long-term exposure to wildfire smoke particles (PM2.5) increases cardiovascular hospitalizations in older adults, highlighting the need for targeted health strategies.Wildfire smoke and stroke: emerging evidence on long-term cardiovascular risk
Zhang S, Chen K. Wildfire smoke and stroke: emerging evidence on long-term cardiovascular risk. European Heart Journal 2026, 47: 2683-2685. PMID: 41587744, DOI: 10.1093/eurheartj/ehaf1003.Commentaries, Editorials and Letters
2025
Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults
Chen H, Zhang S, Pan X, Schneider A, Diaz-Sanchez D, Samet J, Tong H. Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults. Toxics 2025, 13: 1063. PMID: 41441285, PMCID: PMC12737357, DOI: 10.3390/toxics13121063.Peer-Reviewed Original ResearchExposure to PM2.5Short-term air pollution exposureAir pollution exposurePollution exposureAir pollutionAmbient air pollution exposureExposure to air pollutionMixed-effects modelsPollutionN-3 FA groupElevated levelsPlasma concentrationsExposureParticipants' plasma samplesN-3 groupFA groupSpeciesHealthy adultsAssociated with systemic inflammationPro-inflammatory oxylipinsN-3Fatty acid intakeFatty acidsShort-Term Exposure to Low and High Temperatures and Mortality Among Patients With Heart Failure in Sweden
Ni W, Benson L, Ljungman P, Nobile F, Breitner S, Zhang S, de Bont J, Lund L, Savarese G, Schneider A, Agewall S. Short-Term Exposure to Low and High Temperatures and Mortality Among Patients With Heart Failure in Sweden. JAMA Cardiology 2025, 10: 1276-1284. PMID: 41123904, PMCID: PMC12547678, DOI: 10.1001/jamacardio.2025.3932.Peer-Reviewed Original ResearchConceptsCase-crossover studyAll-CauseOdds ratioCardiovascular mortalityCause of Death RegisterRisk of all-causeSwedish National Patient RegisterNational Patient RegisterAll-Cause MortalityStudy periodComorbid atrial fibrillationDeath RegisterAssociated with mortalityPatient RegisterMain OutcomesComorbid diabetesExposure to ambient temperatureDiuretic usersHeart failurePrimary outcomeSwedish patientsMortalityShort-term exposureAssociationRegisterImprovements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change
Huber V, Breitner-Busch S, Feldbusch H, Frieler K, He C, Matthies-Wiesler F, Mengel M, Zhang S, Peters A, Schneider A. Improvements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change. Nature Communications 2025, 16: 11632. PMID: 41298519, PMCID: PMC12748886, DOI: 10.1038/s41467-025-66681-0.Peer-Reviewed Original ResearchExcess mortalityLife expectancyTemperature-mortality associationsAssociated with improvementsHealth outcomesClimate changeDeath burdenAttribution studiesHuman health outcomesTemporal trendsStudy periodNon-climatic driversReanalysis seriesAnthropogenic fingerprintSummer warmingTemperature dataMortalityLifeDoes personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study
Pulczinski J, Zhang S, Breen M, Breen M, Isakov V, Schneider A, Rappold A, Diaz-Sanchez D, Devlin R, Samet J, Tong H. Does personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study. Ecotoxicology And Environmental Safety 2025, 307: 119422. PMID: 41260034, DOI: 10.1016/j.ecoenv.2025.119422.Peer-Reviewed Original ResearchConceptsAir quality monitoringAmbient air pollutionAir pollutionExposure-response relationshipAccurate exposure assessmentLag0Exposure modelExposure assessmentCardiopulmonary biomarkersQuality monitoringPollutionMixed-effects modelsExposureLag4Lag1Cardiopulmonary diseaseNegative associationConcentrationPositive associationAirAssociations of Long-Term Exposure to Temperature Variability with Glucose Metabolism: Results from KORA F4 and FF4
Ni W, Zhang S, Herder C, Breitner-Busch S, Wolf K, Liao M, Nikolaou N, Pickford R, Koenig W, Rathmann W, Schwettmann L, Roden M, Thorand B, Peters A, Schneider A. Associations of Long-Term Exposure to Temperature Variability with Glucose Metabolism: Results from KORA F4 and FF4. Environmental Science And Technology 2025, 59: 24246-24256. PMID: 41200836, PMCID: PMC12631984, DOI: 10.1021/acs.est.5c04956.Peer-Reviewed Original ResearchConceptsKORA F4Homeostasis model assessmentQuantitative insulin sensitivity check indexAssociated with higher fasting insulinPopulation-based cohortExposure to temperature variabilityGlucose metabolismAssessment of B-cell functionGeneralized Estimating EquationsFasting insulinGlucose metabolism biomarkersGlobal diabetes epidemicHigher fasting insulinTemperature variabilityDiabetes prevalenceDiabetes epidemicLongitudinal associationsHealth remainsHOMA-IRFasting GlucoseModel assessment of insulin resistanceAssessment of insulin resistanceHomeostasis model assessment of insulin resistanceMetabolismInsulin sensitivity check index
News
Get In Touch
Contacts
Email