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Kahle Lab Members

Principal Investigator

  • Assistant Professor Adjunct; Pediatrics, and Cellular and Molecular Physiology; Director, Neonatal and Congenital Anomaly Neurosurgery

    MD, Yale School of Medicine, 2007; PhD, Yale University, 2007
    Kristopher T. Kahle, M.D., Ph.D., is an Adjunct Professor of Neurosurgery and Pediatrics and Cellular and Molecular Physiology at Yale School of Medicine, and Director of Neonatal and Congenital Anomaly Neurosurgery in the Division of Pediatric Neurosurgery. He completed his MD and PhD degrees at the Yale School of Medicine under the mentorship of Richard Lifton, and neurosurgical residency at the Massachusetts General Hospital. After residency, Dr. Kahle completed his pediatric neurosurgery fellowship at Boston Children’s Hospital and was Instructor at Harvard Medical School. Dr. Kahle completed a postdoctoral research fellowship with Stephen Elledge and David Clapham at Harvard University. Dr. Kahle’s primary clinical practice includes disorders of neurodevelopment (hydrocephalus, arachnoid cysts, congenital vascular malformations, chiari malformations, spina bifida, and tethered spinal cord) and tumors of the pediatric brain and spinal cord. Dr. Kahle trained in neuroendoscopy, including third ventriculostomy and choroid plexus coagulation, with Dr. Benjamin Warf at Harvard. Dr. Kahle is an attending physician at Yale New Haven Hospital and the Yale New Haven Children’s Hospital. Dr. Kahle’s research is devoted to identifying the genes and pathways that regulate ion and water homeostasis in the developing nervous system, and how genetically-encoded or maladaptive changes in these processes contribute to the cellular, circuit, and behavioral abnormalities in neurodevelopmental disorders and in the traumatized brain. He also uses molecular genetic tools such as whole exome and genome sequencing to discover the molecular determinants of neurodevelopmental diseases, such as congenital hydrocephalus. The goal of his work is to translate advances in basic science into novel therapeutic strategies for pediatric neurosurgical diseases.

Research Scientists/Students

  • Education
    PhD, Yale University School of Medicine, 2021; BS, Johns Hopkins University, 2018
    Research Interests
    • Brain
    • Cerebral Ventricles
    • Nervous System Malformations
    • Neural Tube
    Duy is an MD/PhD student at Yale interested in functional genomics, developmental neurobiology, and pediatric neurosurgery. Duy previously majored in neuroscience at Johns Hopkins University, where he was a Goldwater Scholar and Woodrow Wilson Research Fellow. His NIH F30-funded PhD work, co-mentored by Kristopher Kahle and Nenad Sestan, focused on understanding the molecular genetic mechanisms of developmental brain disorders using unbiased functional genomic approaches in human patients paired with hypothesis-driven neurobiology studies in animal models. Duy's works have led to new understanding of genes involved in formation of the brain-cerebrospinal fluid interface and the embryological mechanisms underlying hydrocephalus, the most common reason for brain surgery in children. His findings have led to first-authored publications in Nature Neuroscience and Neuron and contributing author publications in Nature, Nature Medicine, Journal of Cell Biology, JAMA Neurology, and JAMA Pediatrics. Duy's long-term goals are to define the cellular and molecular pathology of nervous system disorders to thereby develop precision medicine approaches for the care of patients with developmental neurocranial malformations.  Google Scholar: Pubmed: https://pubmed.ncbi.nlm.nih.go...