Publications

• PARG inhibition induces nuclear aggregation of PARylated PARP1.Paradkar S, Purcell J, Cui A, Friedman S, Noronha KJ, Murray MA, Sundaram RK, Bindra RS, Jensen RB. Structure. 2024 Nov 7; 2024 Oct 14. PMID: 39406247.
• Dormant origin firing promotes head-on transcription-replication conflicts at transcription termination sites in response to BRCA2 deficiency.Goehring L, Keegan S, Lahiri S, Xia W, Kong M, Jimenez-Sainz J, Gupta D, Drapkin R, Jensen RB, Smith DJ, Rothenberg E, Fenyö D, Huang TT. Nat Commun. 2024 Jun 3; 2024 Jun 3. PMID: 38830843.
• Human DNA polymerase θ does not harbor intrinsic nuclease activity.Carvajal-Maldonado D, Zahn K, Jensen R, Wood RD, Doublié S. Mol Cell. 2024 Apr 18. PMID: 38640889.
• The importance of considering competing risks in recurrence analysis of intracranial meningioma.Mirian C, Jensen LR, Juratli TA, Maier AD, Torp SH, Shih HA, Morshed RA, Young JS, Magill ST, Bertero L, Stummer W, Spille DC, Brokinkel B, Oya S, Miyawaki S, Saito N, Proescholdt M, Kuroi Y, Gousias K, Simon M, Moliterno J, Prat-Acin R, Goutagny S, Prabhu VC, Tsiang JT, Wach J, Güresir E, Yamamoto J, Kim YZ, Lee JH, Koshy M, Perumal K, Baskaya MK, Cannon DM, Shrieve DC, Suh CO, Chang JH, Kamenova M, Straumann S, Soleman J, Eyüpoglu IY, Catalan T, Lui A, Theodosopoulos PV, McDermott MW, Wang F, Guo F, Góes P, de Paiva Neto MA, Jamshidi A, Komotar R, Ivan M, Luther E, Souhami L, Guiot MC, Csonka T, Endo T, Barrett OC, Jensen R, Gupta T, Patel AJ, Klisch TJ, Kim JW, Maiuri F, Barresi V, Tabernero MD, Skyrman S, Broechner A, Bach MJ, Law I, Scheie D, Kristensen BW, Munch TN, Meling T, Fugleholm K, Blanche P, Mathiesen T. J Neurooncol. 2024 Feb; 2024 Feb 10. PMID: 38336917.
• BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA.Bell JC, Dombrowski CC, Plank JL, Jensen RB, Kowalczykowski SC. Proc Natl Acad Sci U S A. 2023 Apr 4; 2023 Mar 28. PMID: 36976771.
• BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair.Jimenez-Sainz J, Mathew J, Moore G, Lahiri S, Garbarino J, Eder JP, Rothenberg E, Jensen RB. Elife. 2022 Sep 13; 2022 Sep 13. PMID: 36098506.
• DNA fiber combing protocol using in-house reagents and coverslips to analyze replication fork dynamics in mammalian cells.Moore G, Jimenez Sainz J, Jensen RB. STAR Protoc. 2022 Jun 17; 2022 May 5. PMID: 35573479.
• Reply to 'Paracetamol use in pregnancy - neglecting context promotes misinterpretation'.Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Kristensen DM. Nat Rev Endocrinol. 2022 Jun. PMID: 35277661.
• The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus.Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB. Front Genet. 2022; 2022 May 30. PMID: 35711920.
• Reply to 'Paracetamol use in pregnancy - caution over causal inference from available data'; 'Handle with care - interpretation, synthesis and dissemination of data on paracetamol in pregnancy'.Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, M Andrade A, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Kristensen DM. Nat Rev Endocrinol. 2022 Mar. PMID: 34907342.
• Paracetamol use during pregnancy - a call for precautionary action.Bauer AZ, Swan SH, Kriebel D, Liew Z, Taylor HS, Bornehag CG, Andrade AM, Olsen J, Jensen RH, Mitchell RT, Skakkebaek NE, Jégou B, Kristensen DM. Nat Rev Endocrinol. 2021 Dec; 2021 Sep 23. PMID: 34556849.
• Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity.Garbarino J, Eckroate J, Sundaram RK, Jensen RB, Bindra RS. Transl Oncol. 2021 Sep; 2021 Jun 9. PMID: 34118569.
• Polymerase θ Coordinates Multiple Intrinsic Enzymatic Activities during DNA Repair.Zahn KE, Jensen RB. Genes (Basel). 2021 Aug 25; 2021 Aug 25. PMID: 34573292.
• Imprecise Medicine: BRCA2 Variants of Uncertain Significance (VUS), the Challenges and Benefits to Integrate a Functional Assay Workflow with Clinical Decision Rules.Jimenez-Sainz J, Jensen RB. Genes (Basel). 2021 May 20; 2021 May 20. PMID: 34065235.
• RETRACTED: Human DNA polymerase θ harbors DNA end-trimming activity critical for DNA repair.Zahn KE, Jensen RB, Wood RD, Doublié S. Mol Cell. 2021 Apr 1; 2021 Feb 11. PMID: 33577776.
• DNA Strand Exchange to Monitor Human RAD51-Mediated Strand Invasion and Pairing.Lahiri S, Jensen RB. Methods Mol Biol. 2021. PMID: 32840775.
• Preserving genome integrity in human cells via DNA double-strand break repair.Jensen RB, Rothenberg E. Mol Biol Cell. 2020 Apr 15. PMID: 32286930.
• The Post-Synaptic Function of Brca2.Wang CX, Jimenez-Sainz J, Jensen RB, Mazin AV. Sci Rep. 2019 Mar 14; 2019 Mar 14. PMID: 30872704.
• A cell-penetrating antibody inhibits human RAD51 via direct binding.Turchick A, Hegan DC, Jensen RB, Glazer PM. Nucleic Acids Res. 2017 Nov 16. PMID: 29036688.
• BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.Zhao W, Steinfeld JB, Liang F, Chen X, Maranon DG, Jian Ma C, Kwon Y, Rao T, Wang W, Sheng C, Song X, Deng Y, Jimenez-Sainz J, Lu L, Jensen RB, Xiong Y, Kupfer GM, Wiese C, Greene EC, Sung P. Nature. 2017 Oct 19; 2017 Oct 4. PMID: 28976962.
• Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP.Daley JM, Jimenez-Sainz J, Wang W, Miller AS, Xue X, Nguyen KA, Jensen RB, Sung P. Cell Rep. 2017 Oct 10. PMID: 29020620.
• Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G. JAMA Oncol. 2017 May 1. PMID: 28241208.
• A Delphic consensus assessment: imaging and biomarkers in gastroenteropancreatic neuroendocrine tumor disease management.Oberg K, Krenning E, Sundin A, Bodei L, Kidd M, Tesselaar M, Ambrosini V, Baum RP, Kulke M, Pavel M, Cwikla J, Drozdov I, Falconi M, Fazio N, Frilling A, Jensen R, Koopmans K, Korse T, Kwekkeboom D, Maecke H, Paganelli G, Salazar R, Severi S, Strosberg J, Prasad V, Scarpa A, Grossman A, Walenkamp A, Cives M, Virgolini I, Kjaer A, Modlin IM. Endocr Connect. 2016 Sep; 2016 Aug 31. PMID: 27582247.
• The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype.Marsden CG, Jensen RB, Zagelbaum J, Rothenberg E, Morrical SW, Wallace SS, Sweasy JB. PLoS Genet. 2016 Aug; 2016 Aug 11. PMID: 27513445.
• Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity.Chatterjee G, Jimenez-Sainz J, Presti T, Nguyen T, Jensen RB. Nucleic Acids Res. 2016 Jun 20; 2016 Apr 15. PMID: 27084934.
• Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.Zhao W, Vaithiyalingam S, San Filippo J, Maranon DG, Jimenez-Sainz J, Fontenay GV, Kwon Y, Leung SG, Lu L, Jensen RB, Chazin WJ, Wiese C, Sung P. Mol Cell. 2015 Jul 16; 2015 Jul 2. PMID: 26145171.
• A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study.Schuster J, Lai RK, Recht LD, Reardon DA, Paleologos NA, Groves MD, Mrugala MM, Jensen R, Baehring JM, Sloan A, Archer GE, Bigner DD, Cruickshank S, Green JA, Keler T, Davis TA, Heimberger AB, Sampson JH. Neuro Oncol. 2015 Jun; 2015 Jan 13. PMID: 25586468.
• Purification of recombinant 2XMBP tagged human proteins from human cells.Jensen R. Methods Mol Biol. 2014. PMID: 25030930.
• BRCA2: one small step for DNA repair, one giant protein purified.Jensen RB. Yale J Biol Med. 2013 Dec 13; 2013 Dec 13. PMID: 24348212.
• Purified human BRCA2 stimulates RAD51-mediated recombination.Jensen RB, Carreira A, Kowalczykowski SC. Nature. 2010 Oct 7. PMID: 20729832.
• Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions.Jensen R, Glazer PM. Proc Natl Acad Sci U S A. 2004 Apr 20; 2004 Apr 6. PMID: 15069205.
• Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells.Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Mol Cell Biol. 2003 May. PMID: 12697826.
• ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response.Peretz S, Jensen R, Baserga R, Glazer PM. Proc Natl Acad Sci U S A. 2001 Feb 13; 2001 Feb 6. PMID: 11172010.