Publications

• Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity.Nguyen CK, Alvarado M, Huh WJ, Batisti J. Clin J Gastroenterol. 2024 Oct 8; 2024 Oct 8. PMID: 39377877.
• Transcriptomic Profiling Reveals Claudin 18.2 as a Diagnostic Biomarker of Ménétrier's Disease and the Role of Hedgehog Signaling in Pathogenesis.Shin M, Gabriel T, Coffey RJ, Huh WJ. bioRxiv. 2023 Nov 6; 2023 Nov 6. PMID: 37986961.
• VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.Kim SH, Adams TS, Hu Q, Shin HJ, Chae G, Lee SE, Sharma L, Kwon HK, Lee FY, Park HJ, Huh WJ, Manning E, Kaminski N, Sauler M, Chen L, Song JW, Kim TK, Kang MJ. Am J Respir Cell Mol Biol. 2023 Jul. PMID: 36450109.
• Intra-abdominal Cystic Lymphangiomas: The Vanderbilt Experience.Mede A, Chotai PN, Huh WJ, Tan M. J Surg Res. 2023 May; 2023 Jan 23. PMID: 36696706.
• SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia.Willet SG, Thanintorn N, McNeill H, Huh SH, Ornitz DM, Huh WJ, Hoft SG, DiPaolo RJ, Mills JC. Cell Mol Gastroenterol Hepatol. 2023; 2023 Jun 1. PMID: 37270061.
• Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites.Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, Herzon SB, Palm NW. Science. 2022 Oct 28; 2022 Oct 28. PMID: 36302024.
• Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps.Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Cell. 2021 Dec 22; 2021 Dec 14. PMID: 34910928.
• Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets.Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Nat Cell Biol. 2021 Dec; 2021 Dec 9. PMID: 34887515.
• Key histopathologic features in idiopathic noncirrhotic portal hypertension: an interobserver agreement study and proposal for diagnostic criteria.Liang J, Shi C, Dupont WD, Salaria SN, Huh WJ, Correa H, Roland JT, Perri RE, Washington MK. Mod Pathol. 2021 Mar; 2020 Sep 21. PMID: 32958831.
• Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice.Niitsu H, Lu Y, Huh WJ, Love AM, Franklin JL, Coffey RJ. Cell Mol Gastroenterol Hepatol. 2021; 2021 May 11. PMID: 33989815.
• A smooth muscle-derived, Braf-driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell-of-origin.Kondo J, Huh WJ, Franklin JL, Heinrich MC, Rubin BP, Coffey RJ. J Pathol. 2020 Dec; 2020 Oct 15. PMID: 32944951.
• Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.Pinzon-Guzman C, Sangadala S, Riera KM, Popova EY, Manning E, Huh WJ, Alexander MS, Shelton JS, Boden SD, Goldenring JR. J Clin Invest. 2020 Aug 3. PMID: 32427591.
• The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH. Cell. 2020 Apr 16. PMID: 32302568.
• Distribution of duodenal tuft cells is altered in pediatric patients with acute and chronic enteropathy.Huh WJ, Roland JT, Asai M, Kaji I. Biomed Res. 2020. PMID: 32307399.
• Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress.Byrd KM, Piehl NC, Patel JH, Huh WJ, Sequeira I, Lough KJ, Wagner BL, Marangoni P, Watt FM, Klein OD, Coffey RJ, Williams SE. Cell Stem Cell. 2019 Dec 5. PMID: 31809739.
• Linking ALDH1 and retinoic acid signaling.Markham NO, Huh WJ, Coffey RJ. Oncotarget. 2019 Feb 8; 2019 Feb 8. PMID: 30815222.
• A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo.Yang YP, Ma H, Starchenko A, Huh WJ, Li W, Hickman FE, Zhang Q, Franklin JL, Mortlock DP, Fuhrmann S, Carter BD, Ihrie RA, Coffey RJ. Cell Rep. 2017 May 9. PMID: 28494873.
• In liver metastases from small intestinal neuroendocrine tumors, SSTR2A expression is heterogeneous.Charoenpitakchai M, Liu E, Zhao Z, Koyama T, Huh WJ, Berlin J, Hande K, Walker R, Shi C. Virchows Arch. 2017 May; 2017 Feb 17. PMID: 28213807.
• The Spectrum of Histologic Findings in Hepatic Outflow Obstruction.Gonzalez RS, Gilger MA, Huh WJ, Washington MK. Arch Pathol Lab Med. 2017 Jan; 2016 Sep 28. PMID: 27681331.
• Micropapillary colorectal carcinoma: clinical, pathological and molecular properties, including evidence of epithelial-mesenchymal transition.Gonzalez RS, Huh WJ, Cates JM, Washington K, Beauchamp RD, Coffey RJ, Shi C. Histopathology. 2017 Jan; 2016 Oct 28. PMID: 27560620.
• Hepatocyte nuclear factor 4α is required for cell differentiation and homeostasis in the adult mouse gastric epithelium.Moore BD, Khurana SS, Huh WJ, Mills JC. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1; 2016 Jun 23. PMID: 27340127.
• Ménétrier's Disease: Its Mimickers and Pathogenesis.Huh WJ, Coffey RJ, Washington MK. J Pathol Transl Med. 2016 Jan; 2015 Dec 18. PMID: 26689786.
• Chronic tamoxifen use is associated with a decreased risk of intestinal metaplasia in human gastric epithelium.Moon CM, Kim SH, Lee SK, Hyeon J, Koo JS, Lee S, Wang JS, Huh WJ, Khurana SS, Mills JC. Dig Dis Sci. 2014 Jun; 2013 Dec 25. PMID: 24368421.
• Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3.Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Physiol Genomics. 2013 Aug 1; 2013 May 28. PMID: 23715263.
• Tamoxifen induces rapid, reversible atrophy, and metaplasia in mouse stomach.Huh WJ, Khurana SS, Geahlen JH, Kohli K, Waller RA, Mills JC. Gastroenterology. 2012 Jan; 2011 Oct 14. PMID: 22001866.
• XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum.Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC. Gastroenterology. 2010 Dec; 2010 Oct 14. PMID: 20816838.
• The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.Lennerz JK, Kim SH, Oates EL, Huh WJ, Doherty JM, Tian X, Bredemeyer AJ, Goldenring JR, Lauwers GY, Shin YK, Mills JC. Am J Pathol. 2010 Sep; 2010 Aug 13. PMID: 20709804.
• Inducible activation of Cre recombinase in adult mice causes gastric epithelial atrophy, metaplasia, and regenerative changes in the absence of "floxed" alleles.Huh WJ, Mysorekar IU, Mills JC. Am J Physiol Gastrointest Liver Physiol. 2010 Aug; 2010 Apr 22. PMID: 20413717.
• How form follows functional genomics: gene expression profiling gastric epithelial cells with a particular discourse on the parietal cell.Capoccia BJ, Huh WJ, Mills JC. Physiol Genomics. 2009 Apr 10; 2009 Feb 10. PMID: 19208773.
• The gastric epithelial progenitor cell niche and differentiation of the zymogenic (chief) cell lineage.Bredemeyer AJ, Geahlen JH, Weis VG, Huh WJ, Zinselmeyer BH, Srivatsan S, Miller MJ, Shaw AS, Mills JC. Dev Biol. 2009 Jan 1; 2008 Oct 31. PMID: 19013146.
• Location, allocation, relocation: isolating adult tissue stem cells in three dimensions.Huh WJ, Pan XO, Mysorekar IU, Mills JC. Curr Opin Biotechnol. 2006 Oct; 2006 Aug 4. PMID: 16889955.