2019
Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles
Taylor-Giorlando M, Scheinost D, Ment L, Rothman D, Horvath TL. Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles. Cerebral Cortex 2019, 29: 5061-5071. PMID: 30877804, PMCID: PMC6918927, DOI: 10.1093/cercor/bhz046.Peer-Reviewed Original ResearchConceptsMode of deliverySurgical deliveryLayer 3 pyramidal neuronsAlters mitochondrial dynamicsValues of miceMurine findingsCerebral cortexPyramidal neuronsAdult behaviorHuman neonatesMaze testPrepulse inhibitionSpine synapsesPsychiatric illnessAdult miceNeuronal circuitryAnimal modelsClinical relevanceHuman clinical relevanceUCP-2Prefrontal cortexMitochondrial adaptationsImpaired performanceMitochondrial mechanismsBehavioral phenotypes
2004
Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates
Leranth C, Prange-Kiel J, Frick KM, Horvath TL. Low CA1 Spine Synapse Density is Further Reduced by Castration in Male Non-human Primates. Cerebral Cortex 2004, 14: 503-510. PMID: 15054066, DOI: 10.1093/cercor/bhh012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountChlorocebus aethiopsDendritesHumansMaleOrchiectomyPyramidal CellsReference ValuesSynapsesConceptsSpine synapse densitySynapse densityNon-human primatesSpine synapsesCA1 spine synapse densityPyramidal cell apical dendritesCA1 hippocampal areaCell apical dendritesCA1 stratum radiatumFemale non-human primatesMale non-human primatesMale primatesOrchidectomized animalsApical dendritesCA1 areaDendritic shaftsHippocampal areaStratum radiatumGonadal hormonesControl monkeysMale hippocampusGonadectomized animalsOvariectomized femalesAndrogen hormonesPrimate hippocampus
2000
Hormonal regulation of hippocampal spine synapse density involves subcortical mediation
Leranth C, Shanabrough M, Horvath TL. Hormonal regulation of hippocampal spine synapse density involves subcortical mediation. Neuroscience 2000, 101: 349-356. PMID: 11074158, DOI: 10.1016/s0306-4522(00)00369-9.Peer-Reviewed Original ResearchConceptsFimbria/fornix transectionSpine synapse densitySpine densitySynapse densityHippocampal spine synapse densitySubcortical structuresSubcortical mediationPyramidal cell spinesFornix transectionHippocampal CA1 subfieldHippocampal synaptic plasticityCA1 pyramidal cellsFimbria/fornixLong-term potentiationEstrogen replacementIpsilateral hippocampusContralateral hippocampusCA1 subfieldMedian raphePyramidal cellsSupramammillary areaAfferent connectionsHippocampal morphologySeptal complexNew synapses