2022
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons
Xie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, Catarino J, Gu J, Zhao H, Stoddard CE, Carmichael GG, Shanabrough M, Taylor HS, Liu ZW, Gao XB, Horvath TL, Huang Y. TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons. Journal Of Clinical Investigation 2022, 132: e162365. PMID: 36189793, PMCID: PMC9525119, DOI: 10.1172/jci162365.Peer-Reviewed Original ResearchConceptsAgRP neuronsNeuropeptide YExpression of AgRPControl of feedingHypothalamic agoutiAnxiolytic effectsNeurotransmitter GABAMouse modelLeptin signalingStress-like behaviorsGenetic ablationNeuronsAgRPCritical central regulatorsEnergy expenditureGABAEnergy metabolismAppetiteFeedingCentral regulatorMetabolismCentral controlHuman cellsTET3Obesity
2021
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, de la Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C. Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metabolism 2021, 33: 1155-1170.e10. PMID: 33951475, PMCID: PMC8183500, DOI: 10.1016/j.cmet.2021.04.007.Peer-Reviewed Original ResearchConceptsBlood pressureObesity-associated increaseObesity-induced hypertensionElevated blood pressureSystemic blood pressureEndothelial growth factorHIF1α-VEGFArterial hypertensionNovel mechanistic linkSympathetic hyperactivityHemodynamic homeostasisHypothalamic astrocytesMetabolic syndromeRegion-specific lossMacrovascular systemsLeptin signalingBrain centersPathophysiological processesHypertensionGliovascular interfacePathway disruptionGrowth factorAstrocytesMechanistic linkAngiopathy