Bio Profile

Mark W Hochstrasser, PhD

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Research Interests

Enzymes; Molecular Biology; Saccharomyces cerevisiae; Mass Spectrometry; Transcription Factors; Microscopy, Immunoelectron; Gene Deletion; Ubiquitin; Cell Growth Processes; Mutant Chimeric Proteins

Part of the Yale faculty since 2000, Prof. Mark Hochstrasser holds appointments in the Department of Molecular Biophysics and Biochemistry, the Department of Molecular, Cellular and Developmental Biology and the School of Medicine’s Biological and Biomedical Sciences Program. He earned his B.A. at Rutgers University and his Ph.D. at the University of California, San Francisco, and conducted postdoctoral research at the Massachusetts Institute of Technology.

He has earned numerous honors for his...

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John Beckmann

Postdoctoral Associate in Molecular Biophysics and Biochemistry


Biochemistry; Entomology

BA in Art and Physiology, University of Minnesota;

PhD in Entomology, University of Minnesota;

I study the biochemistry and genetics of Wolbachia induced Cytoplasmic Incompatibility in hopes to utilize it as a tool for insect population control.

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Jason Berk, PhD

Postdoctoral Fellow in Molecular Biophysics and Biochemistry

PhD Johns Hopkins University School of Medicine (2012)

BS University of Connecticut (2005)

Jason Berk obtained a B.S. in Molecular and Cellular Biology from the University of Connecticut and his Ph.D. in Cell Biology from Johns Hopkins University, School of Medicine. His doctoral training focused on the function of emerin, a human disease associated, inner nuclear membrane protein. Currently, using a structure-function approach he is attempting to elucidate the mechanism/s of substrate recognition by the membrane embedded E3 ubiquitin ligase, Doa10.

Christopher Hickey, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

Christopher Hickey is a postdoctoral associate in the laboratory of Mark Hochstrasser. He earned a B.S. in Nutritional Sciences from Cornell University and a Ph.D. in Biochemistry at the Geisel School of Medicine at Dartmouth. Dr. Hickey has published extensively on diverse topics within the biological sciences, including metabolism, infectious disease, cellular organization and dynamics, and protein structure and function. His current research focuses on the roles of the ubiquitin and SUMO...

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Jianhui Li

Jianhui Li, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry


Jianhui received his PhD from Virginia Tech and is now working to better understand the molecular mechanisms of proteasome storage granules (PSGs) dissipation and the assembly of proteasome core particle.

Yanjie Li, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

Yanjie Li received her Ph.D. from the University of Toronto in Canada. She then joined the Hochstrasser lab for her postdoc training. Her current research focuses on the 20S proteasome assembly process.


Judith Ronau, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

Judith Ronau obtained her B.S. in Biology from Marquette University and her Ph.D. in Chemistry from Purdue University. Her doctoral research explored the central question of substrate and co-factor binding in the metabolic iron metalloenzyme, phenylalanine hydroxylase and led to the first crystal structure of phenylalanine hydroxylase bound to its natural substrate, phenylalanine. Prior to joining the Hochstrasser lab, Dr. Ronau completed a brief postdoc in Chittaranjan Das' lab at Purdue, where she worked with the deubiquitinating enzymes, AMSH and UCH37. Her current research focuses on cellular localization of the 26S proteasome. 

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Hong-Yeoul Ryu, PhD

Postdoctoral Associate in Molecular Biophysics and Biochemistry

B.S. Molecular and Life Science, Hanyang University (ERICA campus), Republic of Korea


Ph.D. Biochemistry, Hanyang University, Republic of Korea


Study of the function of ubiquitylation and sumoylation in chromatin dynamics, elucidation of the role of histone modifications in the regulation of transcription and heterochromatic silencing, understanding the crosstalk between histone modifications and providing mechanism of their epigenetic inheritance, and analysis of dynamic changes in histone modifications during cell cycle.

Lauren Budenholzer

Graduate Student
Assembly and localization of the proteasome

B.A. Pomona College


Chin Leng Cheng

Graduate Student 
Assembly of the proteasome base

B.Sc. University of Wisconsin, Madison



Hongli Chen


Graduate Student  

B.Sc. Ursinus College

Adrian Mehrtash

Adrian Mehrtash

Graduate Student  

B.Sc. St. Mary's University, Texas


  • Development of a Candida glabrata dominant nutritional transformation marker utilizing the Aspergillus nidulans acetamidase gene (amdS).Fu J, Blaylock M, Wickes CF, Welte W, Mehrtash A, Wiederhold N, Wickes BL. FEMS Yeast Res. 2016 Mar 13.


Arendt, Casey S.
Triathalon coach
Austin, TX 

Bebiana Vigário da Silva Sá Moura, Maria
Currently a Post Doc

Chen, Ping
Associate Professor
Department of Cell Biology
Emory University School of Medicine

Connerly, Pamela L.
Assistant Professor of Biology
Indiana University Southeast (New Albany, IN)

Felberbaum, Rachael
Manager of Scientific Communications
Protein Sciences Corporation (Meriden, CT)  

Gillies, Jennifer 
Meso Scale Diagnostics (Rockville, MD)

Hannich, Thomas
Postdoctoral Fellow (Howard Riezman lab)
Dept. of Biochemistry 
University of Geneva (Switzerland)

Johnson (Roberts), Phoebe
Associate Research Fellow
Pfizer (Boston)

Kroetz, Mary
Postdoc (David Zarkower lab)
Dept. Genetics, Cell Biology, and Development 
University of Minnesota

Kunjappu, Mary
Scientific Solutions at Envision Pharma Group
B.A. Barnard College, Columbia University

Lewis, Alaron
Postdoctoral Fellow (Susan Brockerhoff and Rachel Wong labs)
Dept. Biochemistry 
University of Washington (Seattle, WA)

Papa, Feroz
Associate Professor
Department of Medicine
UCSF (San Francisco, CA)

Schiffer, Linda
Staff Scientist
Dept. Medicine
University of Illinois (Chicago, IL)



emptyemptyemptyemptySwanson, Robert
Associate Professor
Department of Biology
Valparaiso University (Valparaiso, IN)

Swaminathan, Sowmya
Chief Editor
Nature Cell Biology (London, UK)

Wilson, Nikki

Xie, Yang
Presidential Postdoctoral Fellow 
ovartis Institutes for Biomedical Research (Cambridge, MA) 

Zattas, Dimitrios
Research Fellow (Christopher Lima's Lab)
Memorial Sloan Kettering Institute (New York, NY)


Adle, David
Quality Control Scientist
Protein Sciences Corporation (Meriden, CT)

Amerik, Alexander (Sasha)

Bloom, Joanna
Scientific Writer
Envision Pharma

Deng, Min
Dentistry Resident (University of Connecticut)

Funakoshi, Minoru
Section of Educational System Center for Faculty Development 
Okayama University (Okayama, Japan)

Kerscher, Oliver
Associate Professor 
Department of Biology
College of William & Mary (Williamsburg, VA)

Kreft, Stefan
Junior Group Leader
Dept. of Biochemistry
University Konstanz (Germany)

Kusmierczyk, Andrew
Assistant Professor
Department of Biology
Indiana University-Purdue University Indianapolis

Laney, Jeff
Assistant Professor
Department of Mol. & Cell. Biology
University of Arizona (Tucson, AZ)

Li, Shyr-Jiann
Senior Research Scientist
Exelixis, Inc. (South San Francisco, CA)

Li, Xia
Senior Research Associate (Lab of Peter Novick)
Dept. of Cellular & Molecular Medicine 
University of California, San Diego 

Padmanabhan, Achuth   
Postdoctoral Associate 
Dept. of Molecular & Cell Biology 
Baylor College of Medicine 

Pals-Rylaarsdam, Robin
Department Biological Science 
Benedictine University (Lisle, IL)

Radke, Susanne
Research Scientist
Kolltan Pharmaceuticals, Inc. (New Haven, CT)

Ravid, Tommer
Assistant Professor
Dept. of Biological Chemistry
Hebrew University (Jerusalem, Israel)

RubensteinEric (V.J.)  
Assistant Professor
Department of Biology
Ball State University (Muncie, Indiana)

Sakata, Eri
Group Leader at Max Planck Institute

Schwartz, David
Data analyst
Bureau of Western Hemisphere Affairs
Department of State (DC)

Su, Dan   

Tomko Jr.,  Robert J.
Assistant Professor
Department of Biomedical Sciences
Florida State University (Tallahassee, Florida)

Velichutina, Irina
Research Scientist
Albert Einstein College of Medicine

Wang, Lin
Peking Union Medical College (Beijing, China)


Rakhilina, Larissa
Staff Scientist
Regeneron Pharmaceuticals (Tarrytown, NY)