A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung
Li Z, Choo-Wing R, Sun H, Sureshbabu A, Sakurai R, Rehan VK, Bhandari V. A potential role of the JNK pathway in hyperoxia-induced cell death, myofibroblast transdifferentiation and TGF-β1-mediated injury in the developing murine lung. BMC Molecular And Cell Biology 2011, 12: 54. PMID: 22172122, PMCID: PMC3266206, DOI: 10.1186/1471-2121-12-54.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCell LineCell TransdifferentiationCells, CulturedFibroblastsHumansHyperoxiaLungMAP Kinase Signaling SystemMiceMice, TransgenicMyofibroblastsRatsTransforming Growth Factor beta1ConceptsTransgenic mouse modelTGF-β1Myofibroblast transdifferentiationPulmonary responseMouse modelMurine lungJNK pathwayCell deathEpithelial cellsCultured human lung epithelial cellsFetal rat lung fibroblastsHuman lung epithelial cellsDose-dependent mannerRat lung fibroblastsLung epithelial cellsInhibits cell proliferationImpaired alveolarizationLung developmentCell death mediatorsHyperoxiaInhibition of JNKRoom airLung fibroblastsFibroblast proliferationLung