Selected Publications

2023

CD4 T cells and toxicity from immune checkpoint blockade.Earland N, Zhang W, Usmani A, Nene A, Bacchiocchi A, Chen DY, Sznol M, Halaban R, Chaudhuri AA, Newman AM. Immunol Rev. 2023 Sep; 2023 Jul 25. PMID: 37491734.

Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis.Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Nat Commun. 2022 Feb 23; 2022 Feb 23. PMID: 35197475.
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma.Lozano AX, Chaudhuri AA, Nene A, Bacchiocchi A, Earland N, Vesely MD, Usmani A, Turner BE, Steen CB, Luca BA, Badri T, Gulati GS, Vahid MR, Khameneh F, Harris PK, Chen DY, Dhodapkar K, Sznol M, Halaban R, Newman AM. Nat Med. 2022 Feb; 2022 Jan 13. PMID: 35027754.

Early B cell changes predict autoimmunity following combination immune checkpoint blockade.Das R, Bar N, Ferreira M, Newman AM, Zhang L, Bailur JK, Bacchiocchi A, Kluger H, Wei W, Halaban R, Sznol M, Dhodapkar MV, Dhodapkar KM. J Clin Invest. 2018 Feb 1; 2018 Jan 8. PMID: 29309048.

Changes in serum interleukin-8 (IL-8) levels reflect and predict response to anti-PD-1 treatment in melanoma and non-small-cell lung cancer patients.Sanmamed MF, Perez-Gracia JL, Schalper KA, Fusco JP, Gonzalez A, Rodriguez-Ruiz ME, Oñate C, Perez G, Alfaro C, Martín-Algarra S, Andueza MP, Gurpide A, Morgado M, Wang J, Bacchiocchi A, Halaban R, Kluger H, Chen L, Sznol M, Melero I. Ann Oncol. 2017 Aug 1. PMID: 28595336.
Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.Lazova R, Pornputtapong N, Halaban R, Bosenberg M, Bai Y, Chai H, Krauthammer M. Mod Pathol. 2017 May; 2017 Feb 10. PMID: 28186096.

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.Krauthammer M, Kong Y, Bacchiocchi A, Evans P, Pornputtapong N, Wu C, McCusker JP, Ma S, Cheng E, Straub R, Serin M, Bosenberg M, Ariyan S, Narayan D, Sznol M, Kluger HM, Mane S, Schlessinger J, Lifton RP, Halaban R. Nat Genet. 2015 Sep; 2015 Jul 27. PMID: 26214590.

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R. Nat Genet. 2012 Sep; 2012 Jul 29. PMID: 22842228.

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.Halaban R, Zhang W, Bacchiocchi A, Cheng E, Parisi F, Ariyan S, Krauthammer M, McCusker JP, Kluger Y, Sznol M. Pigment Cell Melanoma Res. 2010 Apr; 2010 Feb 10. PMID: 20149136.

Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.Halaban R, Patton RS, Cheng E, Svedine S, Trombetta ES, Wahl ML, Ariyan S, Hebert DN. J Biol Chem. 2002 Apr 26; 2002 Jan 25. PMID: 11812790.

Tyrosinases of murine melanocytes with mutations at the albino locus.Halaban R, Moellmann G, Tamura A, Kwon BS, Kuklinska E, Pomerantz SH, Lerner AB. Proc Natl Acad Sci U S A. 1988 Oct. PMID: 3140237.
bFGF as an autocrine growth factor for human melanomas.Halaban R, Kwon BS, Ghosh S, Delli Bovi P, Baird A. Oncogene Res. 1988 Sep. PMID: 3226725.

Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.Kwon BS, Haq AK, Pomerantz SH, Halaban R. Proc Natl Acad Sci U S A. 1987 Nov. PMID: 2823263.
bFGF is the putative natural growth factor for human melanocytes.Halaban R, Ghosh S, Baird A. In Vitro Cell Dev Biol. 1987 Jan. PMID: 3027025.