Immune cells are an ally, not enemy, in battle against Alzheimer’s
In Alzheimer’s disease (AD), β-amyloid plaques are tightly enveloped by microglia but the significance of this phenomenon is unknown. Here the authors used confocal and in vivo two-photon imaging in AD mouse models and revealed that microglia constitute a physical barrier that prevents the formation of neurotoxic hotspots of protofibrillar β-amyloid and shields adjacent neurons and synapses from the toxic effect of amyloid plaques
Introducing the Internal Medicine 2021-2022 Annual Report
In the new report, there are updates from our clinical programs, research endeavors, our work on diversity, equity, and inclusion, and educational programs. Our faculty members were honored for their educational excellence. Research initiatives at Yale received applause on the national and international stages. This book highlights all that we have accomplished together this past year…
YSM Faculty Developing “Game Changer” for Global Health
Dengue. Zika. Lyme. Yellow fever. Chikungunya virus. Malaria. These worldwide diseases, and others, are spread by the bite from an infected arthropod, a tick or mosquito. Five faculty from Yale School of Medicine (YSM) are collaborating on a project focusing on creating vaccines against infectious diseases by targeting the vector, which could be a “game changer” for global health.
‘Prime and Spike’ Nasal Vaccine Strategy Helps Combat COVID
The new “prime” and “spike” approach may help prevent breakthrough infections of vaccinated individuals by bolstering immune response within the mucosal lining of the respiratory tract, which are the first cells attacked by COVID-19.Source: YaleNews
Marie Robert, MD, Jordan Pober, MD, PhD, Awarded POINTS Grant to Study Pathogenesis of Celiac Disease
Marie Robert, MD, Professor of Pathology and of Medicine (Digestive Diseases), and Jordan Pober, MD, PhD, the Bayer Professor of Translational Medicine and Professor of Immunobiology, Pathology, and Dermatology, have been awarded a grant from the Program for the Promotion of Interdisciplinary Team Science (POINTS) at Yale School of Medicine to study the Pathogenesis of Celiac Disease.
Calorie Reduction Lowers Protein Linked to the Aging Process
In a new study, Yale researchers show that moderate calorie restriction in people reduces the production of a protein called SPARC, which then reins in harmful inflammation and improves health in the aged. It could be a target for extending human health span, they report.
Irina Krykbaeva, PhD, Awarded 2022 Milton C. Winternitz Prize in Pathology
Irina Krykbaeva, a recent PhD graduate in the Department of Pathology at Yale School of Medicine, is the winner of the 2022 Milton C. Winternitz Prize in Pathology. The prize is awarded annually to the student who, in the opinion of the department faculty and staff, has done outstanding work in the course.
Vishwa Deep Dixit, DVM, PhD, Appointed Director of the Yale Center for Research on Aging (Y-Age) and Professor of Pathology at Yale Pathology
Vishwa Deep Dixit, DVM, PhD, the Waldemar Von Zedtwitz Professor of Comparative Medicine and Immunobiology at Yale School of Medicine, will be appointed as Director of the Yale Center for Research on Aging (Y-Age) and Professor of Pathology on January 1, 2022.
Ask tough questions: PhD student Sebastian Diaz
Sebastian Diaz, a PhD student in immunobiology at Yale School of Medicine (YSM), said it’s hard to be among the pioneers, but because medical students from underrepresented backgrounds have pushed for greater emphasis on diversity, equity, and inclusion (DEI) supported by resources “We have a very robust system that is now becoming bigger and bigger every year.”
Common Cold Could Protect Against COVID In Early Stages Of Infection
t’s hard to envision the common cold, caused by rhinoviruses, as something of a superhero, but recent research from Yale University has found this bug to have an intriguing effect on the early success of the pathogen that causes COVID-19 in the body.Source: IFLScience
Women's Health in the Time of COVID-19 Webinar
Uncovering how the coronavirus affects the biology of women and men differently is teaching us new ways to fight COVID-19. Identifying how the stress of the pandemic is different for women and men is focusing mental health professionals on risk and resilience. Watch Women’s Health Research at Yale Director Carolyn M. Mazure, Ph.D, and leading immunologist Akiko Iwasaki, Ph.D., in conversation with Yale Medalist Susanna Krentz, '80, as they discuss a major new research finding and next steps in investigating sex differences to advance the health of women and men.
The Role of Viperin in Viral Protection with Dr. Chun-Chieh ‘Jack’ Hsu
Chun-Chieh ‘Jack’ Hsu, Ph.D., a CRI postdoctoral fellow in the lab of Peter Cresswell, Ph.D., at Yale University, is investigating a protein named viperin that helps promote the elimination of viral infection and is even found in some cancers. But much about viperin and its mechanisms remains unknown, so he’s exploring how it influences immune responses, which could pave the way for future strategies to protect against both viruses and cancers.Source: Cancer Research Institute