2018
2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity
Lou B, Liu Q, Hou J, Kabir I, Liu P, Ding T, Dong J, Mo M, Ye D, Chen Y, Bui HH, Roth K, Cao Y, Jiang XC. 2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity. Journal Of Biological Chemistry 2018, 293: 18328-18336. PMID: 30305392, PMCID: PMC6254338, DOI: 10.1074/jbc.ra118.005904.Peer-Reviewed Original ResearchConceptsSMS activationAnticancer effectsCancer cell cycle arrestU118 cellsDose-dependent fashionSM activityPlasma phosphatidylcholinePredictive biomarkersTumor responseC57BL/6J miceCell cycle arrestTotal cellular phosphatidylcholinePotent anticancer drugLysophosphatidylcholine acyltransferase activitySphingomyelin levelsCancer cellsPhosphatidylcholine metabolismTissue homogenatesSphingomyelin accumulationCycle arrestSphingomyelin synthase activityMouse tissue homogenatesAnticancer propertiesCancer suppressionAcyltransferase activity
2016
Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis
Li Z, Kabir I, Jiang H, Zhou H, Libien J, Zeng J, Stanek A, Ou P, Li KR, Zhang S, Bui HH, Kuo M, Park T, Kim B, Worgall TS, Huan C, Jiang X. Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis. Hepatology 2016, 64: 2089-2102. PMID: 27642075, PMCID: PMC5115983, DOI: 10.1002/hep.28845.Peer-Reviewed Original ResearchConceptsAdherens junctionsSerine palmitoyltransferaseHepatocyte polaritySubunit 2 geneCanonical Wnt pathwaySphingolipid biosynthesisPlasma membraneKey enzymeMajor proteinsWnt pathwayRecombination approachHepatocyte plasma membraneCellular distributionΒ-cateninTumorigenesisCadherin phosphorylationSphingomyelin levelsActivity deficiencyCentral componentPalmitoyltransferaseMembraneCadherinBiosynthesisLiver regenerationGenes