1994
Computed Tomography
Burns A, Pearlson G. Computed Tomography. 1994, 407-426. DOI: 10.1007/978-1-4615-6805-6_23.Peer-Reviewed Original ResearchComputed tomographyCerebral angiographyCerebrovascular accidentHead injuryNon-invasive methodBrain damageIntracerebral lesionsBrain tumorsFirst non-invasive methodClinical practiceClinical neuroscienceIntracranial structuresDementiaTomographyAngiographyInjuryLesionsPneumoencephalographyTumorsDiagnosis
1993
Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder
Harris G, Pearlson G, Hoehn-Saric R. Single Photon Emission Computed Tomography in Obsessive-Compulsive Disorder. JAMA Psychiatry 1993, 50: 498-499. PMID: 8498888, DOI: 10.1001/archpsyc.1993.01820180100015.Peer-Reviewed Original ResearchConceptsOrbital frontal regionsObsessive-compulsive disorderSingle photon emissionBlood flowRegional cerebral blood flowCortical blood flowGroup of patientsCerebral blood flowMedial frontal regionsSPECT studiesAnatomical locationPatientsCompulsive disorderPhoton emissionEt al1DisordersTomographyGroup
1991
Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography
Tune L, Brandt J, Frost J, Harris G, Mayberg H, Steele C, Burns A, Sapp J, Folstein M, Wagner H, Pearlson G. Physostigmine in Alzheimer's disease: effects on cognitive functioning, cerebral glucose metabolism analyzed by positron emission tomography and cerebral blood flow analyzed by single photon emission tomography. Acta Psychiatrica Scandinavica. Supplementum 1991, 83: 61-65. PMID: 1897377, DOI: 10.1111/j.1600-0447.1991.tb03111.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlzheimer DiseaseAmphetaminesBlood GlucoseBrainCerebrovascular CirculationDeoxyglucoseDose-Response Relationship, DrugDrug Administration ScheduleFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeuropsychological TestsPhysostigminePilot ProjectsTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsCerebral glucose metabolismCerebral blood flowSingle photon emission tomographyPhoton emission tomographyPositron emission tomographyBlood flowEmission tomographyGlucose metabolismAlzheimer's diseaseRegional cerebral glucose metabolismSignificant clinical improvementCognitive functioningClinical improvementMost patientsIntravenous administrationPatientsDiseasePhysostigmineTomographyBrain activityPreliminary findingsMetabolismPronounced improvementPathophysiologyIllnessEffects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography
Cascella N, Pearlson G, Wong D, Broussolle E, Nagoshi C, Margolin R, London E. Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography. The British Journal Of Psychiatry 1991, 159: 217-221. PMID: 1773237, DOI: 10.1192/bjp.159.2.217.Peer-Reviewed Original ResearchConceptsSubstance abuseSulcal measuresCocaine useSulcal widthWider third ventriclesEffect of ageBrain atrophyBrain ratioChronic useComputerised tomographyThird ventricleNormal controlsAlcohol consumptionBrain morphologyAlcohol usePolydrug abusersSignificant predictorsAgeVentricleSeverityTomographyPositive correlationAbusePossible effectsVentricular
1986
Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics
Wong D, Wagner H, Tune L, Dannals R, Pearlson G, Links J, Tamminga C, Broussolle E, Ravert H, Wilson A, Toung J, Malat J, Williams J, O'Tuama L, Snyder S, Kuhar M, Gjedde A. Positron Emission Tomography Reveals Elevated D2 Dopamine Receptors in Drug-Naive Schizophrenics. Science 1986, 234: 1558-1563. PMID: 2878495, DOI: 10.1126/science.2878495.Peer-Reviewed Original ResearchConceptsD2 dopamine receptorsD2 dopamine receptor densityPositron emission tomographyGroup of patientsDopamine receptor densityDopamine receptorsCaudate nucleusReceptor densityNormal volunteersEmission tomographyDrug-naive schizophrenicsNumber of receptorsMost patientsBasal gangliaNeuroleptic drugsPostmortem studiesBiochemical abnormalitiesPatientsPsychiatric diseasesSchizophreniaReceptorsDrugsVolunteersTomographyGroup