Kriti Agrawal
About
Research
Publications
2026
T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B
Johnson J, Agrawal K, Al-Lamki R, Zhang F, Wang X, Tobiasova Z, Taleb S, Liburd S, Rodriguez L, Martins A, Flavell R, Robert M, Sefik E, Pober J. T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2525433123. PMID: 41642982, PMCID: PMC12890992, DOI: 10.1073/pnas.2525433123.Peer-Reviewed Original Research
2025
Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody
Newton N, Agrawal K, Odell A, Tracy T, Hacket C, Eldrup A, Whitfield M, Martyanov V, Girardi M, Sefik E, Flavell R, Odell I. Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody. Blood 2025, 146: 3201-3212. PMID: 40961242, PMCID: PMC12643462, DOI: 10.1182/blood.2025029836.Peer-Reviewed Original ResearchHumanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow
Sefik E, Philbrick W, Zhang F, Agrawal K, Van Lee B, Sam J, Karatepe K, Zheng Y, Liang K, Peng S, Mirza H, Rangavajhula A, Simon P, Arun N, Babu P, Eynon E, Chiorazzi M, Shan L, Halene S, Luo H, Rongvaux A, Kluger Y, Flavell R. Humanization of CD47 enables development of functional human neutrophils via postirradiation remodeling of the bone marrow. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2426546122. PMID: 40956886, PMCID: PMC12478129, DOI: 10.1073/pnas.2426546122.Peer-Reviewed Original ResearchEngineering Mice to Study Human Immunity
Sefik E, Xiao T, Chiorazzi M, Odell I, Zhang F, Agrawal K, Micevic G, Flavell R. Engineering Mice to Study Human Immunity. Annual Review Of Immunology 2025, 43: 451-487. PMID: 40020225, DOI: 10.1146/annurev-immunol-082523-124415.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
The single-cell opioid responses in the context of HIV (SCORCH) consortium
Ament S, Campbell R, Lobo M, Receveur J, Agrawal K, Borjabad A, Byrareddy S, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton K, Giglio M, Giorgi F, Gok B, Guda C, Hadas E, Herb B, Hu W, Huttner A, Ishmam M, Jacobs M, Kelschenbach J, Kim D, Lee C, Liu S, Liu X, Madras B, Mahurkar A, Mash D, Mukamel E, Niu M, O’Connor R, Pagan C, Pang A, Pillai P, Repunte-Canonigo V, Ruzicka W, Stanley J, Tickle T, Tsai S, Wang A, Wills L, Wilson A, Wright S, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng C, Corley M, Fox H, Gerstein M, Gummuluru S, Heiman M, Ho Y, Kellis M, Kenny P, Kluger Y, Milner T, Moore D, Morgello S, Ndhlovu L, Rana T, Sanna P, Satterlee J, Sestan N, Spector S, Spudich S, Tilgner H, Volsky D, White O, Williams D, Zeng H. The single-cell opioid responses in the context of HIV (SCORCH) consortium. Molecular Psychiatry 2024, 29: 3950-3961. PMID: 38879719, PMCID: PMC11609103, DOI: 10.1038/s41380-024-02620-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2023
Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation
Lyu F, Burzynski C, Fang Y, Tal A, Chen A, Kisa J, Agrawal K, Kluger Y, Taylor H, Tal R. Maternal CXCR4 deletion results in placental defects and pregnancy loss mediated by immune dysregulation. JCI Insight 2023, 8: e172216. PMID: 37815869, PMCID: PMC10721256, DOI: 10.1172/jci.insight.172216.Peer-Reviewed Original ResearchIL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original Research
2021
Cellular diversity of human cerebral organoids revealed by single cell RNA-seq
Dang J, Tiwari S, Agrawal K, Hui H, Qin Y, Rana T. Cellular diversity of human cerebral organoids revealed by single cell RNA-seq. Molecular Psychiatry 2021, 26: 1043-1043. DOI: 10.1038/s41380-021-01064-7.Peer-Reviewed Original ResearchRapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity
Tang M, Tiwari S, Agrawal K, Tan M, Dang J, Tam T, Tian J, Wan X, Schimelman J, You S, Xia Q, Rana T, Chen S. Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity. Small 2021, 17: e2006050-e2006050. PMID: 33502104, PMCID: PMC8049977, DOI: 10.1002/smll.202006050.Peer-Reviewed Original Research
2020
m6A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy
Wang L, Hui H, Agrawal K, Kang Y, Li N, Tang R, Yuan J, Rana T. m6A RNA methyltransferases METTL3/14 regulate immune responses to anti‐PD‐1 therapy. The EMBO Journal 2020, 39: embj2020104514. PMID: 32964498, PMCID: PMC7560214, DOI: 10.15252/embj.2020104514.Peer-Reviewed Original ResearchAdenosineAnimalsCD8-Positive T-LymphocytesCell Line, TumorCell ProliferationChemokine CXCL10Chemokine CXCL9Colorectal NeoplasmsCytokinesHumansImmune Checkpoint InhibitorsImmunohistochemistryImmunotherapyInterferon Regulatory Factor-1Interferon-gammaMelanomaMethyltransferasesMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 ReceptorRNA-Binding ProteinsRNA-SeqSTAT1 Transcription FactorTumor Microenvironment