Fengrui Zhang
Research Associate 2, MSAbout
Copy Link
Titles
Research Associate 2, MS
Departments & Organizations
- Sefik Lab
Research
Copy Link
Research at a Glance
Yale Co-Authors
Frequent collaborators of Fengrui Zhang's published research.
Publications Timeline
A big-picture view of Fengrui Zhang's research output by year.
Peiying Shan
6Publications
109Citations
Publications
2021
Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells
Ye X, Zhang F, Zhou L, Wei Y, Zhang L, Wang L, Tang H, Chen Z, Kerr W, Zheng T, Zhu Z. Selective deletion of SHIP-1 in hematopoietic cells in mice leads to severe lung inflammation involving ILC2 cells. Scientific Reports 2021, 11: 9220. PMID: 33911168, PMCID: PMC8080607, DOI: 10.1038/s41598-021-88677-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsILC2 cellsLung inflammationPulmonary inflammationAllergic inflammationDendritic cellsLung homeostasisGroup 2 innate lymphoid cellsType 2 immune responsesWild-type control miceSHIP-1IL-5/ILResponsible cell typesSevere lung inflammationSpontaneous pulmonary inflammationType 2 inflammationInnate lymphoid cellsInnate immune cellsWhole-body deletionSpontaneous type 2Hematopoietic cellsPI3K pathwayAllergen stimulationControl miceImmune cellsT cells
2019
SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis
Tang H, Mao J, Ye X, Zhang F, Kerr W, Zheng T, Zhu Z. SHIP‐1, a target of miR‐155, regulates endothelial cell responses in lung fibrosis. The FASEB Journal 2019, 34: 2011-2023. PMID: 31907997, PMCID: PMC7449602, DOI: 10.1096/fj.201902063r.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsMouse lung endothelial cellsLung fibrosisFibrotic responseHuman umbilical vein endothelial cellsMiR-155Endothelial cellsKnockout miceMiR-155 knockout micePrimary mouse lung endothelial cellsMiR-155KO miceSHIP-1Spontaneous lung inflammationPro-inflammatory factorsLung fibrosis modelEndothelial-mesenchymal transitionLung endothelial cellsUmbilical vein endothelial cellsPI3K/AktTGF-β1 stimulationJAK/STAT3Lung inflammationVein endothelial cellsInositol phosphatase-1BLM challengeFibrosis model
2018
Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice
Wei Y, Chhiba K, Zhang F, Ye X, Wang L, Zhang L, Robida P, Moreno-Vinasco L, Schnaar R, Roers A, Hartmann K, Lee C, Demers D, Zheng T, Bochner B, Zhu Z. Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice. International Journal Of Molecular Sciences 2018, 20: 19. PMID: 30577572, PMCID: PMC6337227, DOI: 10.3390/ijms20010019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman Siglec-8Mast cellsSiglec-8Tissue-derived mast cellsSpecific glycan ligandsBone marrow-derived mast cellsSiglec-8 expressionMarrow-derived mast cellsMast cell degranulationMulticolor flow cytometryEmbryonic stem cellsPeritoneal mast cellsCell-specific expressionDifferent cell typesC57BL/6 embryonic stem cellsNovel mouse strainMouse genomeTransgenic linesCell degranulationHomologous recombinationPreclinical studiesTherapeutic targetingChimeric miceEosinophil deathFlow cytometryProtective Functions of Siglec-E and Siglec-9 and Expression of Their Ligands in Mouse Airway Inflammation and Lung Emphysema
Chen Z, Zhang F, Tang H, Porell R, Schnaar R, Kumagai T, Tiemeyer M, Bochner B, Zhou L, Fang C, Zheng T, Zhu Z. Protective Functions of Siglec-E and Siglec-9 and Expression of Their Ligands in Mouse Airway Inflammation and Lung Emphysema. American Journal Of Respiratory And Critical Care Medicine 2018, 197: a7160-a7160. DOI: 10.1164/ajrccm-conference.2018.197.1_meetingabstracts.a7160.Peer-Reviewed Original ResearchFrontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils
O’Sullivan J, Wei Y, Carroll DJ, Moreno-Vinasco L, Cao Y, Zhang F, Lee JJ, Zhu Z, Bochner BS. Frontline Science: Characterization of a novel mouse strain expressing human Siglec-8 only on eosinophils. Journal Of Leukocyte Biology 2018, 104: 11-19. PMID: 29601103, PMCID: PMC6013361, DOI: 10.1002/jlb.2hi0917-391r.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSiglec-8 expressionSiglec-8C motif chemokine receptor 3Mast cell mediator releaseAllergic eosinophilic inflammationAllergic lung inflammationChemokine receptor 3Human Siglec-8Sialic acid-binding immunoglobulin-like lectinsPromising therapeutic targetHuman cell-surface proteinsHuman blood eosinophilsImmunoglobulin-like lectinsAirway challengeOvalbumin sensitizationEosinophilic inflammationLung inflammationMediator releaseBlood eosinophilsMarker CPreclinical studiesMast cellsLittermate controlsTherapeutic targetBone marrow
2017
Sialic Acid-Binding Immunoglobulin-Like Lectin E (Siglec-E) Plays an Important Role in Inflammatory and Emphysematous Responses in Mice
Chen Z, Shan P, Kumagai T, Zhang L, Lee P, Zhang F, Tiemeyer M, Mei Z, Wang Y, Zhou L, Bochner B, Crocker P, Zheng T, Zhu Z. Sialic Acid-Binding Immunoglobulin-Like Lectin E (Siglec-E) Plays an Important Role in Inflammatory and Emphysematous Responses in Mice. American Journal Of Respiratory And Critical Care Medicine 2017, 195: a7368-a7368. DOI: 10.1164/ajrccm-conference.2017.195.1_meetingabstracts.a7368.Peer-Reviewed Original Research