Publications

Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils.Hastings AK, Uraki R, Gaitsch H, Dhaliwal K, Stanley S, Sproch H, Williamson E, MacNeil T, Marin-Lopez A, Hwang J, Wang Y, Grover JR, Fikrig E. J Virol. 2019 Jul 1; 2019 Jun 14. PMID: 30971475.
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice.Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Nat Microbiol. 2019 Jun; 2019 Mar 11. PMID: 30858571.
A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission.Schleicher TR, Yang J, Freudzon M, Rembisz A, Craft S, Hamilton M, Graham M, Mlambo G, Tripathi AK, Li Y, Cresswell P, Sinnis P, Dimopoulos G, Fikrig E. Nat Commun. 2018 Jul 25; 2018 Jul 25. PMID: 30046053.
Immunization with AgTRIO, a Protein in Anopheles Saliva, Contributes to Protection against Plasmodium Infection in Mice.Dragovic SM, Agunbiade TA, Freudzon M, Yang J, Hastings AK, Schleicher TR, Zhou X, Craft S, Chuang YM, Gonzalez F, Li Y, Hrebikova G, Tripathi A, Mlambo G, Almeras L, Ploss A, Dimopoulos G, Fikrig E. Cell Host Microbe. 2018 Apr 11. PMID: 29649443.
Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E. Nat Commun. 2017 Aug 4; 2017 Aug 4. PMID: 28775250.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nature. 2017 Jun 29; 2017 Jun 21. PMID: 28636595.
Zika virus causes testicular atrophy.Uraki R, Hwang J, Jurado KA, Householder S, Yockey LJ, Hastings AK, Homer RJ, Iwasaki A, Fikrig E. Sci Adv. 2017 Feb; 2017 Feb 22. PMID: 28261663.
Pathogen-mediated manipulation of arthropod microbiota to promote infection.Abraham NM, Liu L, Jutras BL, Yadav AK, Narasimhan S, Gopalakrishnan V, Ansari JM, Jefferson KK, Cava F, Jacobs-Wagner C, Fikrig E. Proc Natl Acad Sci U S A. 2017 Jan 31; 2017 Jan 17. PMID: 28096373.
Genetics of War and Truce between Mosquitos and Emerging Viruses.Hwang J, Jurado KA, Fikrig E. Cell Host Microbe. 2016 May 11. PMID: 27173926.
Nlrp6 regulates intestinal antiviral innate immunity.Wang P, Zhu S, Yang L, Cui S, Pan W, Jackson R, Zheng Y, Rongvaux A, Sun Q, Yang G, Gao S, Lin R, You F, Flavell R, Fikrig E. Science. 2015 Nov 13; 2015 Oct 22. PMID: 26494172.
Antivirulence properties of an antifreeze protein.Heisig M, Abraham NM, Liu L, Neelakanta G, Mattessich S, Sultana H, Shang Z, Ansari JM, Killiam C, Walker W, Cooley L, Flavell RA, Agaisse H, Fikrig E. Cell Rep. 2014 Oct 23; 2014 Oct 16. PMID: 25373896.
Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the Lyme disease spirochete.Narasimhan S, Rajeevan N, Liu L, Zhao YO, Heisig J, Pan J, Eppler-Epstein R, Deponte K, Fish D, Fikrig E. Cell Host Microbe. 2014 Jan 15. PMID: 24439898.
ELF4 is critical for induction of type I interferon and the host antiviral response.You F, Wang P, Yang L, Yang G, Zhao YO, Qian F, Walker W, Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. Nat Immunol. 2013 Dec; 2013 Nov 3. PMID: 24185615.
The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity.Silver AC, Arjona A, Walker WE, Fikrig E. Immunity. 2012 Feb 24. PMID: 22342842.
A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent.Schuijt TJ, Coumou J, Narasimhan S, Dai J, Deponte K, Wouters D, Brouwer M, Oei A, Roelofs JJ, van Dam AP, van der Poll T, Van't Veer C, Hovius JW, Fikrig E. Cell Host Microbe. 2011 Aug 18. PMID: 21843870.
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, LeBlanc PM, Doiron K, Saleh M, Fikrig E. Nat Immunol. 2010 Oct; 2010 Sep 5. PMID: 20818395.
A C-type lectin collaborates with a CD45 phosphatase homolog to facilitate West Nile virus infection of mosquitoes.Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. Cell. 2010 Sep 3. PMID: 20797779.
Anaplasma phagocytophilum induces actin phosphorylation to selectively regulate gene transcription in Ixodes scapularis ticks.Sultana H, Neelakanta G, Kantor FS, Malawista SE, Fish D, Montgomery RR, Fikrig E. J Exp Med. 2010 Aug 2; 2010 Jul 26. PMID: 20660616.
Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent.Dai J, Wang P, Adusumilli S, Booth CJ, Narasimhan S, Anguita J, Fikrig E. Cell Host Microbe. 2009 Nov 19. PMID: 19917502.
RNA interference screen for human genes associated with West Nile virus infection.Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, Xavier RJ, Agaisse H, Fikrig E. Nature. 2008 Sep 11. PMID: 18690214.
Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis.Pal U, Wang P, Bao F, Yang X, Samanta S, Schoen R, Wormser GP, Schwartz I, Fikrig E. J Exp Med. 2008 Jan 21; 2007 Dec 31. PMID: 18166585.
A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector.Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, Fikrig E. Cell Host Microbe. 2007 Jul 12. PMID: 18005713.
An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands.Sukumaran B, Narasimhan S, Anderson JF, DePonte K, Marcantonio N, Krishnan MN, Fish D, Telford SR, Kantor FS, Fikrig E. J Exp Med. 2006 Jun 12; 2006 May 22. PMID: 16717118.
The Lyme disease agent exploits a tick protein to infect the mammalian host.Ramamoorthi N, Narasimhan S, Pal U, Bao F, Yang XF, Fish D, Anguita J, Norgard MV, Kantor FS, Anderson JF, Koski RA, Fikrig E. Nature. 2005 Jul 28. PMID: 16049492.
TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi.Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, Desilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF, Fikrig E. Cell. 2004 Nov 12. PMID: 15537536.
Molecular adaptation of Borrelia burgdorferi in the murine host.Liang FT, Nelson FK, Fikrig E. J Exp Med. 2002 Jul 15. PMID: 12119353.
Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation.Anguita J, Ramamoorthi N, Hovius JW, Das S, Thomas V, Persinski R, Conze D, Askenase PW, Rincón M, Kantor FS, Fikrig E. Immunity. 2002 Jun. PMID: 12121666.