2017
Upregulation of Epac-1 in hepatic stellate cells by Prostaglandin E2 in liver fibrosis is associated with reduced fibrogenesis.
Schippers M, Beljaars L, Post E, Lotersztajn S, Reker-Smit C, Han B, Munoz-Llancao P, Schmidt M, Poelstra K. Upregulation of Epac-1 in hepatic stellate cells by Prostaglandin E2 in liver fibrosis is associated with reduced fibrogenesis. Journal Of Pharmacology And Experimental Therapeutics 2017, 363: jpet.117.241646. PMID: 28864467, DOI: 10.1124/jpet.117.241646.Peer-Reviewed Original ResearchConceptsEpac-1 activationEpac-1Hepatic stellate cellsNiflumic acidPlatelet-derived growth factor-induced proliferationLiver fibrosisFibrotic livers of miceReduced Rho-kinase activityKupffer cellsIsolated hepatic stellate cellsStellate cellsCAMP-mediated effectsGrowth factor-induced proliferationWeeks carbon tetrachlorideEffect of PGE<sub>2</sub> onEPAC-1 expressionKinase activityProtein kinase A expressionRho-kinase activityWestern blot analysisActivity in vitroProstaglandin E<sub>2</sub>Cyclo-oxygenase productsDownstream targetsCell-specific deliveryMicrotubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation
Muñoz‐Llancao P, de Gregorio C, Heras M, Meinohl C, Noorman K, Boddeke E, Cheng X, Lezoualc'h F, Schmidt M, Gonzalez‐Billault C. Microtubule‐regulating proteins and cAMP‐dependent signaling in neuroblastoma differentiation. Cytoskeleton 2017, 74: 143-158. PMID: 28164467, DOI: 10.1002/cm.21355.Peer-Reviewed Original ResearchConceptsMicrotubule-regulating proteinsN1E-115 cellsMicrotubule-stabilizing factorsDifferentiation of N1E-115 neuroblastoma cellsPKA-AKAP interactionsMicrotubule-destabilizing proteinNeuroblastoma cellsEpac-dependent signalingFunctions of EPACDifferentiated neuroblastoma cellsInduce neuronal differentiationCAMP-dependent signalingN1E-115Analog of cyclic AMPN1E-115 neuroblastoma cellsIntracellular domainMicrotubule stabilityDb-cAMPCell biologyCell differentiationEpac activationNeuroblastoma differentiationNeuronal differentiationDifferentiated cellsNeuronal cells
2014
A‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases
Poppinga W, Muñoz‐Llancao P, González‐Billault C, Schmidt M. A‐kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. British Journal Of Pharmacology 2014, 171: 5603-5623. PMID: 25132049, PMCID: PMC4290705, DOI: 10.1111/bph.12882.Peer-Reviewed Original ResearchConceptsA-kinase anchoring proteinsCAMP compartmentationCAMP effector proteinsCompartmentalized cAMP signalingGs protein-coupled receptorsCellular content of cAMPEffector proteinsCompartmentalization of cAMPAnchoring proteinsCAMP compartmentCellular functionsContent of cAMPA-kinaseCAMP signalingProtein-coupled receptorsActivation of PKAObstructive pulmonary diseaseMessenger cAMPExchange proteinCellular contentAlzheimer's diseaseNeurodegenerative diseasesProteinB2-adrenoceptorsPulmonary disease
2012
The role of small GTPases in neuronal morphogenesis and polarity
Gonzalez‐Billault C, Muñoz‐Llancao P, Henriquez D, Wojnacki J, Conde C, Caceres A. The role of small GTPases in neuronal morphogenesis and polarity. Cytoskeleton 2012, 69: 464-485. PMID: 22605667, DOI: 10.1002/cm.21034.Peer-Reviewed Original ResearchConceptsNeuronal morphogenesisRegulation of cytoskeletal dynamicsParticipation of RhoASmall GTPasesActin cytoskeletonCytoskeletal dynamicsNeuronal polarityDynamic remodelingMorphogenetic eventsGTPaseCross-talkMorphogenesisAxonal elongationFamily membersSynaptic plasticityCdc42CytoskeletonRhoATC10ActinMicrotubulesRacRegulation