Publications

• LRRK2, lysosome damage, and Parkinson's disease.Bentley-DeSousa A, Clegg D, Ferguson SM. Curr Opin Cell Biol. 2025 Apr; 2025 Feb 20. PMID: 39983584.
• Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology.Gould E, Fraser HS, Parker TH, Nakagawa S, Griffith SC, Vesk PA, Fidler F, Hamilton DG, Abbey-Lee RN, Abbott JK, Aguirre LA, Alcaraz C, Aloni I, Altschul D, Arekar K, Atkins JW, Atkinson J, Baker CM, Barrett M, Bell K, Bello SK, Beltrán I, Berauer BJ, Bertram MG, Billman PD, Blake CK, Blake S, Bliard L, Bonisoli-Alquati A, Bonnet T, Bordes CNM, Bose APH, Botterill-James T, Boyd MA, Boyle SA, Bradfer-Lawrence T, Bradham J, Brand JA, Brengdahl MI, Bulla M, Bussière L, Camerlenghi E, Campbell SE, Campos LLF, Caravaggi A, Cardoso P, Carroll CJW, Catanach TA, Chen X, Chik HYJ, Choy ES, Christie AP, Chuang A, Chunco AJ, Clark BL, Contina A, Covernton GA, Cox MP, Cressman KA, Crotti M, Crouch CD, D'Amelio PB, de Sousa AA, Döbert TF, Dobler R, Dobson AJ, Doherty TS, Drobniak SM, Duffy AG, Duncan AB, Dunn RP, Dunning J, Dutta T, Eberhart-Hertel L, Elmore JA, Elsherif MM, English HM, Ensminger DC, Ernst UR, Ferguson SM, Fernandez-Juricic E, Ferreira-Arruda T, Fieberg J, Finch EA, Fiorenza EA, Fisher DN, Fontaine A, Forstmeier W, Fourcade Y, Frank GS, Freund CA, Fuentes-Lillo E, Gandy SL, Gannon DG, García-Cervigón AI, Garretson AC, Ge X, Geary WL, Géron C, Gilles M, Girndt A, Gliksman D, Goldspiel HB, Gomes DGE, Good MK, Goslee SC, Gosnell JS, Grames EM, Gratton P, Grebe NM, Greenler SM, Griffioen M, Griffith DM, Griffith FJ, Grossman JJ, Güncan A, Haesen S, Hagan JG, Hager HA, Harris JP, Harrison ND, Hasnain SS, Havird JC, Heaton AJ, Herrera-Chaustre ML, Howard TJ, Hsu BY, Iannarilli F, Iranzo EC, Iverson ENK, Jimoh SO, Johnson DH, Johnsson M, Jorna J, Jucker T, Jung M, Kačergytė I, Kaltz O, Ke A, Kelly CD, Keogan K, Keppeler FW, Killion AK, Kim D, Kochan DP, Korsten P, Kothari S, Kuppler J, Kusch JM, Lagisz M, Lalla KM, Larkin DJ, Larson CL, Lauck KS, Lauterbur ME, Law A, Léandri-Breton DJ, Lembrechts JJ, L'Herpiniere K, Lievens EJP, de Lima DO, Lindsay S, Luquet M, MacLeod R, Macphie KH, Magellan K, Mair MM, Malm LE, Mammola S, Mandeville CP, Manhart M, Manrique-Garzon LM, Mäntylä E, Marchand P, Marshall BM, Martin CA, Martin DA, Martin JM, Martinig AR, McCallum ES, McCauley M, McNew SM, Meiners SJ, Merkling T, Michelangeli M, Moiron M, Moreira B, Mortensen J, Mos B, Muraina TO, Murphy PW, Nelli L, Niemelä P, Nightingale J, Nilsonne G, Nolazco S, Nooten SS, Novotny JL, Olin AB, Organ CL, Ostevik KL, Palacio FX, Paquet M, Parker DJ, Pascall DJ, Pasquarella VJ, Paterson JH, Payo-Payo A, Pedersen KM, Perez G, Perry KI, Pottier P, Proulx MJ, Proulx R, Pruett JL, Ramananjato V, Randimbiarison FT, Razafindratsima OH, Rennison DJ, Riva F, Riyahi S, Roast MJ, Rocha FP, Roche DG, Román-Palacios C, Rosenberg MS, Ross J, Rowland FE, Rugemalila D, Russell AL, Ruuskanen S, Saccone P, Sadeh A, Salazar SM, Sales K, Salmón P, Sánchez-Tójar A, Santos LP, Santostefano F, Schilling HT, Schmidt M, Schmoll T, Schneider AC, Schrock AE, Schroeder J, Schtickzelle N, Schultz NL, Scott DA, Scroggie MP, Shapiro JT, Sharma N, Shearer CL, Simón D, Sitvarin MI, Skupien FL, Slinn HL, Smith GP, Smith JA, Sollmann R, Whitney KS, Still SM, Stuber EF, Sutton GF, Swallow B, Taff CC, Takola E, Tanentzap AJ, Tarjuelo R, Telford RJ, Thawley CJ, Thierry H, Thomson J, Tidau S, Tompkins EM, Tortorelli CM, Trlica A, Turnell BR, Urban L, Van de Vondel S, van der Wal JEM, Van Eeckhoven J, van Oordt F, Vanderwel KM, Vanderwel MC, Vanderwolf KJ, Vélez J, Vergara-Florez DC, Verrelli BC, Vieira MV, Villamil N, Vitali V, Vollering J, Walker J, Walker XJ, Walter JA, Waryszak P, Weaver RJ, Wedegärtner REM, Weller DL, Whelan S, White RL, Wolfson DW, Wood A, Yanco SW, Yen JDL, Youngflesh C, Zilio G, Zimmer C, Zimmerman GM, Zitomer RA. BMC Biol. 2025 Feb 6; 2025 Feb 6. PMID: 39915771.
• A STING-CASM-GABARAP pathway activates LRRK2 at lysosomes.Bentley-DeSousa A, Roczniak-Ferguson A, Ferguson SM. J Cell Biol. 2025 Feb 3; 2025 Jan 15. PMID: 39812709.
• Lysosomal TBK1 responds to amino acid availability to relieve Rab7-dependent mTORC1 inhibition.Talaia G, Bentley-DeSousa A, Ferguson SM. EMBO J. 2024 Sep; 2024 Aug 5. PMID: 39103493.
• Intracellular calcium links milk stasis to lysosome-dependent cell death during early mammary gland involution.Jeong J, Lee J, Talaia G, Kim W, Song J, Hong J, Yoo K, Gonzalez DG, Athonvarangkul D, Shin J, Dann P, Haberman AM, Kim LK, Ferguson SM, Choi J, Wysolmerski J. Cell Mol Life Sci. 2024 Jan 12; 2024 Jan 12. PMID: 38212474.
• Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition.Talaia G, Bentley-DeSousa A, Ferguson SM. bioRxiv. 2023 Dec 17; 2023 Dec 17. PMID: 38168426.
• A kinesin-1 adaptor complex controls bimodal slow axonal transport of spectrin in Caenorhabditis elegans.Glomb O, Swaim G, Munoz LLancao P, Lovejoy C, Sutradhar S, Park J, Wu Y, Cason SE, Holzbaur ELF, Hammarlund M, Howard J, Ferguson SM, Gramlich MW, Yogev S. Dev Cell. 2023 Oct 9; 2023 Sep 25. PMID: 37751746.
• LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition.Yadavalli N, Ferguson SM. Proc Natl Acad Sci U S A. 2023 Aug; 2023 Jul 24. PMID: 37487100.
• Cab45 deficiency leads to the mistargeting of progranulin and prosaposin and aberrant lysosomal positioning.Tran ML, Tüshaus J, Kim Y, Ramazanov BR, Devireddy S, Lichtenthaler SF, Ferguson SM, von Blume J. Traffic. 2023 Jan. PMID: 36398980.
• ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling.Hancock-Cerutti W, Wu Z, Xu P, Yadavalli N, Leonzino M, Tharkeshwar AK, Ferguson SM, Shadel GS, De Camilli P. J Cell Biol. 2022 Jul 4; 2022 Jun 3. PMID: 35657605.
• Efficient progranulin exit from the ER requires its interaction with prosaposin, a Surf4 cargo.Devireddy S, Ferguson SM. J Cell Biol. 2022 Feb 7; 2021 Dec 17. PMID: 34919127.
• JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton.Rafiq NM, Lyons LL, Gowrishankar S, De Camilli P, Ferguson SM. Commun Biol. 2022 Jan 10; 2022 Jan 10. PMID: 35013510.
• TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.Alesi N, Akl EW, Khabibullin D, Liu HJ, Nidhiry AS, Garner ER, Filippakis H, Lam HC, Shi W, Viswanathan SR, Morroni M, Ferguson SM, Henske EP. Nat Commun. 2021 Jul 12; 2021 Jul 12. PMID: 34253722.
• Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons.Gowrishankar S, Lyons L, Rafiq NM, Roczniak-Ferguson A, De Camilli P, Ferguson SM. Mol Biol Cell. 2021 May 15; 2021 Mar 31. PMID: 33788575.
• PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer's disease.Nackenoff AG, Hohman TJ, Neuner SM, Akers CS, Weitzel NC, Shostak A, Ferguson SM, Mobley B, Bennett DA, Schneider JA, Jefferson AL, Kaczorowski CC, Schrag MS. PLoS Genet. 2021 Apr; 2021 Apr 8. PMID: 33830999.
• Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids.Talaia G, Amick J, Ferguson SM. Proc Natl Acad Sci U S A. 2021 Feb 23. PMID: 33597295.
• Coordination of Rheb lysosomal membrane interactions with mTORC1 activation.Angarola B, Ferguson SM. F1000Res. 2020; 2020 May 27. PMID: 32518628.
• PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation.Amick J, Tharkeshwar AK, Talaia G, Ferguson SM. J Cell Biol. 2020 Jan 6. PMID: 31851326.
• Weak membrane interactions allow Rheb to activate mTORC1 signaling without major lysosome enrichment.Angarola B, Ferguson SM. Mol Biol Cell. 2019 Oct 15; 2019 Sep 18. PMID: 31532697.
• Pleiotropic requirements for human TDP-43 in the regulation of cell and organelle homeostasis.Roczniak-Ferguson A, Ferguson SM. Life Sci Alliance. 2019 Oct; 2019 Sep 16. PMID: 31527135.
• Neuronal lysosomes.Ferguson SM. Neurosci Lett. 2019 Apr 1; 2018 Apr 4. PMID: 29626653.
• Lysosomes Dare Cells to be Different(iated).Roczniak-Ferguson A, Ferguson SM. Cell Stem Cell. 2019 Feb 7. PMID: 30735644.
• WDR41 supports lysosomal response to changes in amino acid availability.Amick J, Tharkeshwar AK, Amaya C, Ferguson SM. Mol Biol Cell. 2018 Sep 1; 2018 Jul 11. PMID: 29995611.
• GATOR1-dependent recruitment of FLCN-FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids.Meng J, Ferguson SM. J Cell Biol. 2018 Aug 6; 2018 May 30. PMID: 29848618.
• Axonal transport and maturation of lysosomes.Ferguson SM. Curr Opin Neurobiol. 2018 Aug; 2018 Mar 9. PMID: 29529416.
• The complex relationship between TFEB transcription factor phosphorylation and subcellular localization.Puertollano R, Ferguson SM, Brugarolas J, Ballabio A. EMBO J. 2018 Jun 1; 2018 May 15. PMID: 29764979.
• Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr. Proc Natl Acad Sci U S A. 2018 Mar 20; 2018 Mar 6. PMID: 29511098.
• Organelles in metabolism and stress responses.Ferguson SM, Henne WM. Mol Biol Cell. 2018 Mar 15. PMID: 29535175.
• Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology.Gowrishankar S, Wu Y, Ferguson SM. J Cell Biol. 2017 Oct 2; 2017 Aug 7. PMID: 28784610.
• B-cell non-Hodgkin lymphoma: Selective vulnerability to PIKFYVE inhibition.Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Xu T, Rothberg J, Lichenstein H. Autophagy. 2017 Jun 3; 2017 Mar 28. PMID: 28350209.
• C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.Amick J, Ferguson SM. Traffic. 2017 May; 2017 Mar 23. PMID: 28266105.
• Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.Gayle S, Landrette S, Beeharry N, Conrad C, Hernandez M, Beckett P, Ferguson SM, Mandelkern T, Zheng M, Xu T, Rothberg J, Lichenstein H. Blood. 2017 Mar 30; 2017 Jan 19. PMID: 28104689.
• A lentiviral system for efficient knockdown of proteins in neuronal cultures [version 1; referees: 2 approved].Ritter B, Ferguson SM, De Camilli P, McPherson PS. MNI Open Res. 2017; 2017 Dec 5. PMID: 29355247.
• C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling.Amick J, Roczniak-Ferguson A, Ferguson SM. Mol Biol Cell. 2016 Oct 15; 2016 Aug 24. PMID: 27559131.
• Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB.Gray MA, Choy CH, Dayam RM, Ospina-Escobar E, Somerville A, Xiao X, Ferguson SM, Botelho RJ. Curr Biol. 2016 Aug 8; 2016 Jul 7. PMID: 27397893.
• Lysosomes relax in the cellular suburbs.Gowrishankar S, Ferguson SM. J Cell Biol. 2016 Mar 14. PMID: 26975848.
• MEDICINE. Membrane traffic en route to cancer.Ferguson SM. Science. 2015 Oct 9. PMID: 26450197.
• Beyond indigestion: emerging roles for lysosome-based signaling in human disease.Ferguson SM. Curr Opin Cell Biol. 2015 Aug; 2015 May 15. PMID: 25950843.
• Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.Gowrishankar S, Yuan P, Wu Y, Schrag M, Paradise S, Grutzendler J, De Camilli P, Ferguson SM. Proc Natl Acad Sci U S A. 2015 Jul 14; 2015 Jun 29. PMID: 26124111.
• Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes.Willinger T, Staron M, Ferguson SM, De Camilli P, Flavell RA. Proc Natl Acad Sci U S A. 2015 Apr 7; 2015 Mar 23. PMID: 25831514.
• Dynamin and endocytosis are required for the fusion of osteoclasts and myoblasts.Shin NY, Choi H, Neff L, Wu Y, Saito H, Ferguson SM, De Camilli P, Baron R. J Cell Biol. 2014 Oct 13; 2014 Oct 6. PMID: 25287300.
• A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P. Elife. 2014 Jun 24; 2014 Jun 24. PMID: 24963135.
• Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling.Willinger T, Ferguson SM, Pereira JP, De Camilli P, Flavell RA. J Exp Med. 2014 Apr 7; 2014 Mar 17. PMID: 24638168.
• Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis.Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Development. 2014 Apr; 2014 Mar 5. PMID: 24598168.
• Essential function of dynamin in the invasive properties and actin architecture of v-Src induced podosomes/invadosomes.Destaing O, Ferguson SM, Grichine A, Oddou C, De Camilli P, Albiges-Rizo C, Baron R. PLoS One. 2013; 2013 Dec 9. PMID: 24348990.
• Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.Park RJ, Shen H, Liu L, Liu X, Ferguson SM, De Camilli P. J Cell Sci. 2013 Nov 15; 2013 Sep 17. PMID: 24046449.
• Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.Petit CS, Roczniak-Ferguson A, Ferguson SM. J Cell Biol. 2013 Sep 30. PMID: 24081491.
• Role of dynamin, synaptojanin, and endophilin in podocyte foot processes.Soda K, Balkin DM, Ferguson SM, Paradise S, Milosevic I, Giovedi S, Volpicelli-Daley L, Tian X, Wu Y, Ma H, Son SH, Zheng R, Moeckel G, Cremona O, Holzman LB, De Camilli P, Ishibe S. J Clin Invest. 2012 Dec; 2012 Nov 26. PMID: 23187129.
• The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis.Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM. Sci Signal. 2012 Jun 12; 2012 Jun 12. PMID: 22692423.
• Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.Sousa LP, Lax I, Shen H, Ferguson SM, De Camilli P, Schlessinger J. Proc Natl Acad Sci U S A. 2012 Mar 20; 2012 Feb 27. PMID: 22371560.
• Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger LL, Ferguson SM, De Camilli P. Proc Natl Acad Sci U S A. 2012 Feb 21; 2012 Jan 30. PMID: 22308498.
• Dynamin, a membrane-remodelling GTPase.Ferguson SM, De Camilli P. Nat Rev Mol Cell Biol. 2012 Jan 11; 2012 Jan 11. PMID: 22233676.
• Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.Raimondi A, Ferguson SM, Lou X, Armbruster M, Paradise S, Giovedi S, Messa M, Kono N, Takasaki J, Cappello V, O'Toole E, Ryan TA, De Camilli P. Neuron. 2011 Jun 23. PMID: 21689597.
• Constitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynamin.Shen H, Ferguson SM, Dephoure N, Park R, Yang Y, Volpicelli-Daley L, Gygi S, Schlessinger J, De Camilli P. Mol Biol Cell. 2011 Feb 15; 2010 Dec 17. PMID: 21169560.
• Coordinated actions of actin and BAR proteins upstream of dynamin at endocytic clathrin-coated pits.Ferguson SM, Raimondi A, Paradise S, Shen H, Mesaki K, Ferguson A, Destaing O, Ko G, Takasaki J, Cremona O, O' Toole E, De Camilli P. Dev Cell. 2009 Dec. PMID: 20059951.
• Selective saturation of slow endocytosis at a giant glutamatergic central synapse lacking dynamin 1.Lou X, Paradise S, Ferguson SM, De Camilli P. Proc Natl Acad Sci U S A. 2008 Nov 11; 2008 Nov 5. PMID: 18987309.
• Cell- and stimulus-dependent heterogeneity of synaptic vesicle endocytic recycling mechanisms revealed by studies of dynamin 1-null neurons.Hayashi M, Raimondi A, O'Toole E, Paradise S, Collesi C, Cremona O, Ferguson SM, De Camilli P. Proc Natl Acad Sci U S A. 2008 Feb 12; 2008 Feb 4. PMID: 18250322.
• A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.Ferguson SM, Brasnjo G, Hayashi M, Wölfel M, Collesi C, Giovedi S, Raimondi A, Gong LW, Ariel P, Paradise S, O'toole E, Flavell R, Cremona O, Miesenböck G, Ryan TA, De Camilli P. Science. 2007 Apr 27. PMID: 17463283.