Dixit Lab Publications

• Enhanced paracrine action of FGF21 in stromal cells delays thymic aging.Youm YH, Gliniak C, Zhang Y, Dlugos T, Scherer PE, Dixit VD. Nat Aging. 2025 Apr; 2025 Feb 19. PMID: 39972172.
• Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida.Rogina B, Anderson R, Lebrasseur N, Curan S, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean Iii D, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Ralmundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. J Gerontol A Biol Sci Med Sci. 2025 Feb 11; 2025 Feb 11. PMID: 39932386.
• Defying "IL-11ness" by inhibiting inflammation: Strategy for health and longevity.Kim HH, Dixit VD. Cell Metab. 2024 Sep 3. PMID: 39232279.
• Cysteine depletion triggers adipose tissue thermogenesis and weight-loss.Lee AH, Orliaguet L, Youm YH, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey S, Smith SR, Ravussin E, Stadler K, Hyder F, Artyomov MN, Sugiura Y, Dixit VD. bioRxiv. 2024 Aug 8; 2024 Aug 8. PMID: 39149397.
• Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023.Burak MF, Stanley TL, Lawson EA, Campbell SL, Lynch L, Hasty AH, Domingos AI, Dixit VD, Hotamışlıgil GS, Sheedy FJ, Dixon AE, Brinkley TE, Hill JA, Donath MY, Grinspoon SK. Am J Clin Nutr. 2024 Jul; 2024 May 3. PMID: 38705359.
• Reduction of SPARC protects mice against NLRP3 inflammasome activation and obesity.Ryu S, Spadaro O, Sidorov S, Lee AH, Caprio S, Morrison C, Smith SR, Ravussin E, Shchukina I, Artyomov MN, Youm YH, Dixit VD. J Clin Invest. 2023 Oct 2; 2023 Oct 2. PMID: 37781916.
• When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging.Mihaylova MM, Chaix A, Delibegovic M, Ramsey JJ, Bass J, Melkani G, Singh R, Chen Z, Ja WW, Shirasu-Hiza M, Latimer MN, Mattison JA, Thalacker-Mercer AE, Dixit VD, Panda S, Lamming DW. Cell Metab. 2023 Jul 11; 2023 Jun 30. PMID: 37392742.
• [WITHDRAWN] Activation of transsulfuration pathway to maintain cysteine is a thermogenic checkpoint for the conservation of energy.Lee AH, Sugiura Y, Youm YH, Dlugos T, Maeda R, Coman D, Spadaro O, Sidorov S, Shchukina I, Andhey S, Smith SR, Ravussin E, Hyder F, Artyomov MN, Dixit VD. Res Sq. 2023 Jun 30; 2023 Jun 30. PMID: 37461682.
• Innate immune cell-intrinsic ketogenesis is dispensable for organismal metabolism and age-related inflammation.Goldberg EL, Letian A, Dlugos T, Leveau C, Dixit VD. J Biol Chem. 2023 Mar; 2023 Feb 10. PMID: 36775129.
• Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds.Schuppe AW, Liu Y, Gonzalez-Hurtado E, Zhao Y, Jiang X, Ibarraran S, Huang D, Wang E, Lee J, Loria JP, Dixit VD, Li X, Newhouse TR. Chem. 2022 Oct 13; 2022 Oct 4. PMID: 37396824.
• The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging.Ryu S, Sidorov S, Ravussin E, Artyomov M, Iwasaki A, Wang A, Dixit VD. Immunity. 2022 Sep 13; 2022 Aug 12. PMID: 35963236.
• Caloric restriction in humans reveals immunometabolic regulators of health span.Spadaro O, Youm Y, Shchukina I, Ryu S, Sidorov S, Ravussin A, Nguyen K, Aladyeva E, Predeus AN, Smith SR, Ravussin E, Galban C, Artyomov MN, Dixit VD. Science. 2022 Feb 11; 2022 Feb 10. PMID: 35143297.
• IL-27 signalling promotes adipocyte thermogenesis and energy expenditure.Wang Q, Li D, Cao G, Shi Q, Zhu J, Zhang M, Cheng H, Wen Q, Xu H, Zhu L, Zhang H, Perry RJ, Spadaro O, Yang Y, He S, Chen Y, Wang B, Li G, Liu Z, Yang C, Wu X, Zhou L, Zhou Q, Ju Z, Lu H, Xin Y, Yang X, Wang C, Liu Y, Shulman GI, Dixit VD, Lu L, Yang H, Flavell RA, Yin Z. Nature. 2021 Dec; 2021 Nov 24. PMID: 34819664.
• Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Proc Natl Acad Sci U S A. 2021 Nov 23. PMID: 34782454.
• IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2.Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. Cell Metab. 2021 Nov 2; 2021 Sep 1. PMID: 34473956.
• Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice.Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov M, Wang A, Dixit VD. Elife. 2021 Jun 21; 2021 Jun 21. PMID: 34151773.
• Adiponectin preserves metabolic fitness during aging.Li N, Zhao S, Zhang Z, Zhu Y, Gliniak CM, Vishvanath L, An YA, Wang MY, Deng Y, Zhu Q, Shan B, Sherwood A, Onodera T, Oz OK, Gordillo R, Gupta RK, Liu M, Horvath TL, Dixit VD, Scherer PE. Elife. 2021 Apr 27; 2021 Apr 27. PMID: 33904399.
• Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome.Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Nat Aging. 2021 Jan; 2020 Nov 23. PMID: 34796338.
• Dietary Regulation of Immunity.Lee AH, Dixit VD. Immunity. 2020 Sep 15. PMID: 32937152.
• Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue.Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. Nat Metab. 2020 Jan; 2020 Jan 20. PMID: 32694683.
• Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Cell Metab. 2019 Dec 3; 2019 Nov 14. PMID: 31735593.
• Ketogenic diet activates protective γδ T cell responses against influenza virus infection.Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. Sci Immunol. 2019 Nov 15. PMID: 31732517.
• Bone Marrow: An Immunometabolic Refuge during Energy Depletion.Goldberg EL, Dixit VD. Cell Metab. 2019 Oct 1. PMID: 31577929.
• Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance.Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. J Physiol. 2019 Aug; 2019 Jul 4. PMID: 31206703.
• Gaining Weight: Insulin-Eating Islet Macrophages.Spadaro O, Dixit VD. Immunity. 2019 Jan 15. PMID: 30650372.
• Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity.Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Cell Rep. 2018 Jul 31. PMID: 30067966.
• Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms.Ferrandino G, Kaspari RR, Spadaro O, Reyna-Neyra A, Perry RJ, Cardone R, Kibbey RG, Shulman GI, Dixit VD, Carrasco N. Proc Natl Acad Sci U S A. 2017 Oct 24; 2017 Oct 10. PMID: 29073114.
• Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. Nature. 2017 Oct 5; 2017 Sep 27. PMID: 28953873.
• Energy Sparing Orexigenic Inflammation of Obesity.Lee A, Dixit VD. Cell Metab. 2017 Jul 5. PMID: 28683278.
• IGF1 Shapes Macrophage Activation in Response to Immunometabolic Challenge.Spadaro O, Camell CD, Bosurgi L, Nguyen KY, Youm YH, Rothlin CV, Dixit VD. Cell Rep. 2017 Apr 11. PMID: 28402847.
• β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares.Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. Cell Rep. 2017 Feb 28. PMID: 28249154.
• Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation.Goldberg EL, Dixit VD. Mol Metab. 2017 Feb; 2017 Jan 3. PMID: 28180063.
• Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L. Aging (Albany NY). 2016 Jul. PMID: 27410480.
• A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents.Kursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. Diabetes. 2016 Mar; 2015 Dec 30. PMID: 26718495.
• Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. Cell Rep. 2016 Feb 23; 2016 Feb 11. PMID: 26876170.
• Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.Youm YH, Horvath TL, Mangelsdorf DJ, Kliewer SA, Dixit VD. Proc Natl Acad Sci U S A. 2016 Jan 26; 2016 Jan 11. PMID: 26755598.
• Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity.Camell CD, Nguyen KY, Jurczak MJ, Christian BE, Shulman GI, Shadel GS, Dixit VD. J Biol Chem. 2015 Dec 4; 2015 Oct 5. PMID: 26438821.
• Editorial: "Crowning" eosinophils in adipose tissue: does location matter?Goldberg EL, Dixit VD. J Leukoc Biol. 2015 Oct. PMID: 26429777.
• Drivers of age-related inflammation and strategies for healthspan extension.Goldberg EL, Dixit VD. Immunol Rev. 2015 May. PMID: 25879284.
• The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. Nat Med. 2015 Mar; 2015 Feb 16. PMID: 25686106.
• Inactivation of C/ebp homologous protein-driven immune-metabolic interactions exacerbate obesity and adipose tissue leukocytosis.Grant R, Nguyen KY, Ravussin A, Albarado D, Youm YH, Dixit VD. J Biol Chem. 2014 May 16; 2014 Mar 24. PMID: 24662293.
• Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity.Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ, Murphy AJ. Cell Metab. 2014 May 6. PMID: 24807222.