DiMaio Lab Research

Our research focuses on the papillomaviruses and polyomaviruses, small DNA viruses that transform cells in culture and play an important role in several forms of human cancer and other diseases. Our current studies aim to determine at the molecular level how viral oncogenes transform cells and cause cancer and how these viruses use cellular machinery to enter cells.


BPV E5 Protein

The laboratory is studying the mechanism of action of the smallest known naturally occurring oncoprotein, the 44-amino acid E5 protein expressed by bovine papillomavirus. We showed that the...


Artificial Small Transmembrane Proteins as Novel Agents to Modulate Cell Behavior and Study Protein-protein Interactions

Based on our analysis of the BPV E5 protein, we devised a genetic approach to construct and identify small transmembrane proteins that can alter cell behavior. We have isolated artificial...

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Tumor Virus Entry

Entry of tumor viruses into cells is the first step in viral-mediated tumorigenesis. Virus entry is a complex, multi-step process that requires numerous cellular proteins. We are using...


Studies of Cervical Carcinoma and Senescence

The laboratory is investigating the role of the human papillomavirus E6 and E7 proteins in cervical cancer and oropharyngeal cancer, with particular attention to their ability to inhibit...