Publications

• Glucagon-Like Peptide-1 Is Prognostic of Mortality in Acute Respiratory Failure.Hansell CE, Aneis HA, Kitsios GD, Bain WG, Zhao Y, Suber TL, Evankovich JW, Sharma L, Ramakrishnan SK, Prendergast NT, Hensley MK, Malik S, Petro N, Patel JJ, Nouraie SM, Dela Cruz CS, Zhang Y, McVerry BJ, Shah FA. Crit Care Explor. 2025 Apr 1; 2025 Mar 24. PMID: 40126931.
• Questions and Answers about Measles.Pasnick S, Keller JM, Dela Cruz CS, Gross JE, Carlos Iii WG, Maves R, Jamil S, Collins B, Sundar K. Am J Respir Crit Care Med. 2025 Mar 25; 2025 Mar 25. PMID: 40130871.
• Host-Directed Adjunctive Therapies in Immunocompromised Patients with Pneumonia.Hensley MK, Dela Cruz CS. Clin Chest Med. 2025 Mar; 2024 Dec 9. PMID: 39890291.
• Therapeutic JAK inhibition does not impact lung injury during viral or bacterial pneumonia in male mice.Sharma L, Singh RB, Ngeow C, van der Geest R, Duray AM, Tolman NJ, McVerry BJ, Dela Cruz CS, Alcorn JF, Bain W, Robinson KM. Physiol Rep. 2025 Feb. PMID: 39921246.
• Early antiviral use and supplemental oxygen decrease the risk of secondary bacterial infections: a multi-centre, nested, case-control study.Zhu Y, Hu H, Guo X, Zhang H, Li D, Dela Cruz CS, Xie W, Xie L, Sharma L, Chang D. J Hosp Infect. 2025 Feb; 2024 Dec 17. PMID: 39701496.
• Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection.Kim J, Yuan Y, Agaronyan K, Zhao A, Wang VD, Gau D, Toosi N, Gupta G, Essayas H, Kaminski A, McGovern J, Yu S, Woo S, Lee CJ, Gandhi S, Saber T, Saleh T, Hu B, Sun Y, Ishikawa G, Bain W, Evankovich J, Chen L, Yun H, Herzog EL, Dela Cruz CS, Ryu C, Sharma L. Mucosal Immunol. 2025 Jan 28; 2025 Jan 28. PMID: 39884393.
• Streptococcus pneumoniae Serotype Distribution Among US Adults Hospitalized With Community-Acquired Pneumonia, 2019-2020.Ramirez JA, Hubler RA, Ali M, Gray SL, Carrico R, McNaughton CD, Wunderink RG, Dela Cruz CS, Chilson EL, Cané AD, Isturiz RE, Pride MW, Jodar L, Gessner BD, Grant LR. Open Forum Infect Dis. 2025 Jan; 2024 Dec 17. PMID: 39758745.
• World Pneumonia Day 2024: Fighting Pneumonia and Antimicrobial Resistance.Cilloniz C, Dela Cruz CS, Dy-Agra G, Pagcatipunan RS Jr. Am J Respir Crit Care Med. 2024 Dec 1. PMID: 39530671.
• Prior knowledge-guided vision-transformer-based unsupervised domain adaptation for intubation prediction in lung disease at one week.Yang J, Henao JAG, Dvornek N, He J, Bower DV, Depotter A, Bajercius H, de Mortanges AP, You C, Gange C, Ledda RE, Silva M, Dela Cruz CS, Hautz W, Bonel HM, Reyes M, Staib LH, Poellinger A, Duncan JS. Comput Med Imaging Graph. 2024 Dec; 2024 Oct 15. PMID: 39515190.
• The protein disulfide isomerase A3 and osteopontin axis promotes influenza-induced lung remodelling.Kumar A, Mark ZF, Carbajal MP, DeLima DS, Chamberlain N, Walzer J, Ruban M, Chandrasekaran R, Daphtary N, Aliyeva M, Poynter ME, Janssen-Heininger YMW, Bates JH, Alcorn JF, Britto CJ, Dela Cruz CS, Jegga AG, Anathy V. Br J Pharmacol. 2024 Nov; 2024 Aug 8. PMID: 39118388.
• Context-specific anti-inflammatory roles of type III interferon signaling in the lung in nonviral injuries.Feng J, Kim J, Wang VD, Chang D, Liu H, Bain WG, Robinson KM, Jie Z, Kotenko SV, Dela Cruz CS, Sharma L. Physiol Rep. 2024 Oct. PMID: 39455422.
• Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya JD, Dela Cruz CS, Herzog EL, Kaminski N. Am J Respir Crit Care Med. 2024 Aug 15. PMID: 38717443.
• Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection.Kim J, Yuan Y, Agaronyan K, Zhao A, D Wang V, Gupta G, Essayas H, Kaminski A, McGovern J, Yu S, Woo S, Lee CJ, Gandhi S, Saber T, Saleh T, Hu B, Sun Y, Ishikawa G, Bain W, Evankovich J, Chen L, Yun H, Herzog EL, Dela Cruz CS, Ryu C, Sharma L. bioRxiv. 2024 Aug 12; 2024 Aug 12. PMID: 38496452.
• Clinical features and multiomics profiles indicate coagulation and platelet dysfunction in COVID-19 viral sepsis.Xiao Z, Lin M, Song N, Wu X, Hou J, Wang L, Tian X, An C, Dela Cruz CS, Sharma L, Chang D. iScience. 2024 Jun 21; 2024 May 25. PMID: 38974472.
• A dual role for CRTH2 in acute lung injury.Bhattacharya S, Ristic N, Cohen AJ, Tsang D, Gwin M, Howell R, Young G, Jung E, Dela Cruz CS, Gautam S. bioRxiv. 2024 May 2; 2024 May 2. PMID: 35665001.
• Anti-inflammatory roles of type I interferon signaling in the lung.Feng J, Liu Y, Kim J, Ahangari F, Kaminski N, Bain WG, Jie Z, Dela Cruz CS, Sharma L. Am J Physiol Lung Cell Mol Physiol. 2024 May 1; 2024 Feb 20. PMID: 38375579.
• Developmental changes in lung function of mice are independent of sex as a biological variable.Bärnthaler T, Ramachandra AB, Ebanks S, Guerrera N, Sharma L, Dela Cruz CS, Humphrey JD, Manning EP. Am J Physiol Lung Cell Mol Physiol. 2024 May 1; 2024 Feb 20. PMID: 38375577.
• Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract.Mao T, Kim J, Peña-Hernández MA, Valle G, Moriyama M, Luyten S, Ott IM, Gomez-Calvo ML, Gehlhausen JR, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee CJ, Silva Monteiro V, Lucas C, Dong H, Yang Y, Gopinath S, Wilen CB, Palm N, Dela Cruz CS, Iwasaki A. Proc Natl Acad Sci U S A. 2024 Apr 30; 2024 Apr 22. PMID: 38648490.
• A Multiclass Radiomics Method-Based WHO Severity Scale for Improving COVID-19 Patient Assessment and Disease Characterization From CT Scans.Henao JAG, Depotter A, Bower DV, Bajercius H, Todorova PT, Saint-James H, de Mortanges AP, Barroso MC, He J, Yang J, You C, Staib LH, Gange C, Ledda RE, Caminiti C, Silva M, Cortopassi IO, Dela Cruz CS, Hautz W, Bonel HM, Sverzellati N, Duncan JS, Reyes M, Poellinger A. Invest Radiol. 2023 Dec 1; 2023 Jul 27. PMID: 37493348.
• Distinguishing features of long COVID identified through immune profiling.Klein J, Wood J, Jaycox JR, Dhodapkar RM, Lu P, Gehlhausen JR, Tabachnikova A, Greene K, Tabacof L, Malik AA, Silva Monteiro V, Silva J, Kamath K, Zhang M, Dhal A, Ott IM, Valle G, Peña-Hernández M, Mao T, Bhattacharjee B, Takahashi T, Lucas C, Song E, McCarthy D, Breyman E, Tosto-Mancuso J, Dai Y, Perotti E, Akduman K, Tzeng TJ, Xu L, Geraghty AC, Monje M, Yildirim I, Shon J, Medzhitov R, Lutchmansingh D, Possick JD, Kaminski N, Omer SB, Krumholz HM, Guan L, Dela Cruz CS, van Dijk D, Ring AM, Putrino D, Iwasaki A. Nature. 2023 Nov; 2023 Sep 25. PMID: 37748514.
• The Impact of Coronavirus Disease 2019 on Viral, Bacterial, and Fungal Respiratory Infections.Losier A, Gupta G, Caldararo M, Dela Cruz CS. Clin Chest Med. 2023 Jun; 2023 Feb 26. PMID: 37085229.
• Immunomodulatory Agents for Coronavirus Disease-2019 Pneumonia.McManus D, Davis MW, Ortiz A, Britto-Leon C, Dela Cruz CS, Topal JE. Clin Chest Med. 2023 Jun; 2022 Nov 22. PMID: 37085221.
• Single-cell profiling reveals immune aberrations in progressive idiopathic pulmonary fibrosis.Unterman A, Zhao AY, Neumark N, Schupp JC, Ahangari F, Cosme C Jr, Sharma P, Flint J, Stein Y, Ryu C, Ishikawa G, Sumida TS, Gomez JL, Herazo-Maya J, Dela Cruz CS, Herzog EL, Kaminski N. medRxiv. 2023 Apr 29; 2023 Apr 29. PMID: 37163015.
• Coronaviruses, Lysosomes, and Secondary Bacterial Infections: Coronaviruses Outsmart the Host.Peng X, Dela Cruz CS, Sharma L. DNA Cell Biol. 2023 Apr; 2023 Feb 10. PMID: 36763591.
• Immunocompromised Host Pneumonia: Definitions and Diagnostic Criteria: An Official American Thoracic Society Workshop Report.Cheng GS, Crothers K, Aliberti S, Bergeron A, Boeckh M, Chien JW, Cilloniz C, Cohen K, Dean N, Dela Cruz CS, Dickson RP, Greninger AL, Hage CA, Hohl TM, Holland SM, Jones BE, Keane J, Metersky M, Miller R, Puel A, Ramirez J, Restrepo MI, Sheshadri A, Staitieh B, Tarrand J, Winthrop KL, Wunderink RG, Evans SE. Ann Am Thorac Soc. 2023 Mar. PMID: 36856712.
• microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis.Ahangari F, Price NL, Malik S, Chioccioli M, Bärnthaler T, Adams TS, Kim J, Pradeep SP, Ding S, Cosmos C Jr, Rose KS, McDonough JE, Aurelien NR, Ibarra G, Omote N, Schupp JC, DeIuliis G, Villalba Nunez JA, Sharma L, Ryu C, Dela Cruz CS, Liu X, Prasse A, Rosas I, Bahal R, Fernández-Hernando C, Kaminski N. JCI Insight. 2023 Feb 22; 2023 Feb 22. PMID: 36626225.
• Nonutility of procalcitonin for diagnosing bacterial pneumonia in patients with severe COVID-19.Cohen AJ, Glick LR, Lee S, Kunitomo Y, Tsang DA, Pitafi S, Valda Toro P, Ristic NR, Zhang E, Carey GB, Datta R, Dela Cruz CS, Gautam S. Eur Clin Respir J. 2023; 2023 Feb 8. PMID: 36815942.
• Glucocorticoid Therapy in COVID-19.Amati F, Tonutti A, Huston J, Dela Cruz CS. Semin Respir Crit Care Med. 2023 Feb; 2023 Jan 16. PMID: 36646089.
• COVID-19.Dela Cruz CS, Feldman C. Semin Respir Crit Care Med. 2023 Feb; 2023 Jan 16. PMID: 36646080.
• PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infection.Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein SH, Montgomery RR, Iwasaki A, Dela Cruz CS, Kaminski N, Shaw AC, Hafler DA, Sumida TS. Cell Rep. 2023 Jan 31; 2023 Jan 2. PMID: 36596303.
• Identification of two specific transcriptomic clusters of COVID-19 acute respiratory distress syndrome patients with different immune profiles and different outcomes.Shindo Y, Dela Cruz CS, Witzenrath M. Eur Respir J. 2023 Jan; 2023 Jan 27. PMID: 36517181.
• Adding Insult to Injury: Does COVID-19 Promote Acute Respiratory Distress Syndrome by Inhibiting Surfactant?Richmond BW, Dela Cruz CS. Am J Respir Crit Care Med. 2023 Jan 1. PMID: 35976979.
• Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.Ahangari F, Becker C, Foster DG, Chioccioli M, Nelson M, Beke K, Wang X, Justet A, Adams T, Readhead B, Meador C, Correll K, Lili LN, Roybal HM, Rose KA, Ding S, Barnthaler T, Briones N, DeIuliis G, Schupp JC, Li Q, Omote N, Aschner Y, Sharma L, Kopf KW, Magnusson B, Hicks R, Backmark A, Dela Cruz CS, Rosas I, Cousens LP, Dudley JT, Kaminski N, Downey GP. Am J Respir Crit Care Med. 2022 Dec 15. PMID: 35998281.
• Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. J Immunol. 2022 Oct 1; 2022 Sep 2. PMID: 36165196.
• Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2.Ssenyange G, Kerfoot M, Zhao M, Farhadian S, Chen S, Peng L, Ren P, Dela Cruz CS, Gupta S, Sutton RE. Cell Rep Methods. 2022 Jul 18; 2022 Jun 20. PMID: 35757815.
• Summary for Clinicians: Clinical Practice Guideline for the Use of Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia.Losier A, Harding WC, Dela Cruz CS, Evans S, Ruminjo JK, Thomson C. Ann Am Thorac Soc. 2022 Jul. PMID: 35353672.
• Tissue remodeling by an opportunistic pathogen triggers allergic inflammation.Agaronyan K, Sharma L, Vaidyanathan B, Glenn K, Yu S, Annicelli C, Wiggen TD, Penningroth MR, Hunter RC, Dela Cruz CS, Medzhitov R. Immunity. 2022 May 10; 2022 Apr 27. PMID: 35483356.
• Multiscale PHATE identifies multimodal signatures of COVID-19.Kuchroo M, Huang J, Wong P, Grenier JC, Shung D, Tong A, Lucas C, Klein J, Burkhardt DB, Gigante S, Godavarthi A, Rieck B, Israelow B, Simonov M, Mao T, Oh JE, Silva J, Takahashi T, Odio CD, Casanovas-Massana A, Fournier J, Farhadian S, Dela Cruz CS, Ko AI, Hirn MJ, Wilson FP, Hussin JG, Wolf G, Iwasaki A, Krishnaswamy S. Nat Biotechnol. 2022 May; 2022 Feb 28. PMID: 35228707.
• Nonutility of procalcitonin for diagnosing bacterial pneumonia in COVID-19.Cohen AJ, Glick LR, Lee S, Kunitomo Y, Tsang DA, Pitafi S, Toro PV, Zhang E, Datta R, Dela Cruz CS, Gautam S. medRxiv. 2022 Apr 5; 2022 Apr 5. PMID: 35411344.
• New testing guidelines for community-acquired pneumonia.Losier A, Dela Cruz CS. Curr Opin Infect Dis. 2022 Apr 1. PMID: 35245248.
• Emerging insights in sarcoidosis: moving forward through reverse translational research.Liu A, Sharma L, Yan X, Dela Cruz CS, Herzog EL, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2022 Apr 1; 2022 Feb 23. PMID: 35196896.
• Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report.Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Am J Respir Cell Mol Biol. 2022 Feb. PMID: 35103557.
• Postnatal Sepsis and Bronchopulmonary Dysplasia in Premature Infants: Mechanistic Insights into "New BPD".Salimi U, Dummula K, Tucker MH, Dela Cruz CS, Sampath V. Am J Respir Cell Mol Biol. 2022 Feb. PMID: 34644520.
• Association of circulating cell-free double-stranded DNA and metabolic derangements in idiopathic pulmonary fibrosis.Whalen W, Buyukozkan M, Moore B, Moon JS, Dela Cruz CS, Martinez FJ, Choi AMK, Krumsiek J, Stout-Delgado H, Cho SJ. Thorax. 2022 Feb; 2021 Sep 14. PMID: 34521729.
• Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection.Sharma L, Peng X, Qing H, Hilliard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kim SH, Kang MJ, Ishibe S, Young LH, Kotenko S, Compton S, Wilen CB, Wang A, Dela Cruz CS. J Virol. 2022 Jan 26; 2021 Oct 27. PMID: 34705554.
• Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Nat Commun. 2022 Jan 21; 2022 Jan 21. PMID: 35064122.
• Clinical Epidemiology, Risk Factors, and Control Strategies of Klebsiella pneumoniae Infection.Chang D, Sharma L, Dela Cruz CS, Zhang D. Front Microbiol. 2021; 2021 Dec 22. PMID: 34992583.
• High-resolution epitope mapping and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19.Haynes WA, Kamath K, Bozekowski J, Baum-Jones E, Campbell M, Casanovas-Massana A, Daugherty PS, Dela Cruz CS, Dhal A, Farhadian SF, Fitzgibbons L, Fournier J, Jhatro M, Jordan G, Klein J, Lucas C, Kessler D, Luchsinger LL, Martinez B, Catherine Muenker M, Pischel L, Reifert J, Sawyer JR, Waitz R, Wunder EA Jr, Zhang M, Iwasaki A, Ko A, Shon JC. Commun Biol. 2021 Nov 22; 2021 Nov 22. PMID: 34811480.
• SPLUNC1: a novel marker of cystic fibrosis exacerbations.Khanal S, Webster M, Niu N, Zielonka J, Nunez M, Chupp G, Slade MD, Cohn L, Sauler M, Gomez JL, Tarran R, Sharma L, Dela Cruz CS, Egan M, Laguna T, Britto CJ. Eur Respir J. 2021 Nov; 2021 Nov 11. PMID: 33958427.
• Design and rationale of the colchicine/statin for the prevention of COVID-19 complications (COLSTAT) trial.Shah T, McCarthy M, Nasir I, Archer H, Ragheb E, Kluger J, Kashyap N, Paredes C, Patel P, Lu J, Kandel P, Song C, Khan M, Ul Haq F, Ahmad R, Howes C, Cambi B, Lancaster G, Cleman M, Dela Cruz CS, Parise H, Lansky A. Contemp Clin Trials. 2021 Nov; 2021 Aug 28. PMID: 34461322.
• Community-acquired pneumonia.Aliberti S, Dela Cruz CS, Amati F, Sotgiu G, Restrepo MI. Lancet. 2021 Sep 4. PMID: 34481570.
• Repetitive aeroallergen challenges elucidate maladaptive epithelial and inflammatory traits that underpin allergic airway diseases.Smith AM, Harper N, Meunier JA, Branum AP, Jimenez F, Pandranki L, Carrillo A, Dela Cruz CS, Restrepo MI, Maselli DJ, Rather CG, Heisser AH, Ramirez DA, He W, Clark RA, Andrews CP, Evans SE, Pugh JA, Zhang N, Lee GC, Moreira AG, Segal LN, Ramirez RM, Jacobs RL, Manoharan MS, Okulicz JF, Ahuja SK. J Allergy Clin Immunol. 2021 Aug; 2021 Jan 23. PMID: 33493557.
• Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.Dela Cruz CS, Evans SE, Restrepo MI, Dean N, Torres A, Amara-Elori I, Awasthi S, Caler E, Cao B, Chalmers JD, Chastre J, Cohen TS, Cohen AH, Crothers K, Di YP, Egan ME, Feldman C, Gautam S, Halstead ES, Herold S, Jones BE, Luna C, Niederman MS, Mendez R, Menendez R, Mizgerd JP, Nusrat R, Ramirez J, Shindo Y, Waterer G, Yeligar SM, Wunderink RG. Ann Am Thorac Soc. 2021 Jul. PMID: 34242148.
• Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients.George S, Pal AC, Gagnon J, Timalsina S, Singh P, Vydyam P, Munshi M, Chiu JE, Renard I, Harden CA, Ott IM, Watkins AE, Vogels CBF, Lu P, Tokuyama M, Venkataraman A, Casanovas-Massana A, Wyllie AL, Rao V, Campbell M, Farhadian SF, Grubaugh ND, Dela Cruz CS, Ko AI, Berna Perez AZ, Akaho EH, Moledina DG, Testani J, John AR, Ledizet M, Mamoun CB. Kidney360. 2021 Jun 24; 2021 Apr 14. PMID: 35373072.
• Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2.Zhao M, Su PY, Castro DA, Tripler TN, Hu Y, Cook M, Ko AI, Farhadian SF, Israelow B, Dela Cruz CS, Xiong Y, Sutton RE. PLoS Pathog. 2021 Jun; 2021 Jun 24. PMID: 34166473.
• Cutting Edge: Distinct B Cell Repertoires Characterize Patients with Mild and Severe COVID-19.Hoehn KB, Ramanathan P, Unterman A, Sumida TS, Asashima H, Hafler DA, Kaminski N, Dela Cruz CS, Sealfon SC, Bukreyev A, Kleinstein SH. J Immunol. 2021 Jun 15; 2021 May 28. PMID: 34049971.
• Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes.Minasyan M, Sharma L, Pivarnik T, Liu W, Adams T, Bermejo S, Peng X, Liu A, Ishikawa G, Perry C, Kaminski N, Gulati M, Herzog EL, Dela Cruz CS, Ryu C. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 1; 2021 Apr 14. PMID: 33851886.
• Psychological Impact During the First Outbreak of COVID-19 on Frontline Health Care Workers in Shanghai.Feng J, Xu J, Xu S, Cao H, Zheng C, Sharma L, Dela Cruz CS, Zhang J, Chu D, Yu L, Tu C, Li F, Ren T, Zhang F, Du C, Gu W, Liu H, Qian Y, Shen C, Tang C, Bi Y, Xiao F, Gu K, Zhang J, Ye Z, Zhao L, Zhai J, Hu X, Qu J, Jie Z. Front Public Health. 2021; 2021 May 17. PMID: 34079783.
• Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.Ma L, Sahu SK, Cano M, Kuppuswamy V, Bajwa J, McPhatter J, Pine A, Meizlish ML, Goshua G, Chang CH, Zhang H, Price C, Bahel P, Rinder H, Lei T, Day A, Reynolds D, Wu X, Schriefer R, Rauseo AM, Goss CW, O’Halloran JA, Presti RM, Kim AH, Gelman AE, Dela Cruz CS, Lee AI, Mudd PA, Chun HJ, Atkinson JP, Kulkarni HS. Sci Immunol. 2021 May 13. PMID: 34446527.
• Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Immunity. 2021 May 11; 2021 Apr 13. PMID: 33891889.
• One Size Does Not Fit All: Moving Towards a Personalized Approach for Steroids in COVID-19.Amati F, Dela Cruz CS. Chest. 2021 May. PMID: 33965120.
• Nucleic Acid-based Testing for Noninfluenza Viral Pathogens in Adults with Suspected Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline.Evans SE, Jennerich AL, Azar MM, Cao B, Crothers K, Dickson RP, Herold S, Jain S, Madhavan A, Metersky ML, Myers LC, Oren E, Restrepo MI, Semret M, Sheshadri A, Wunderink RG, Dela Cruz CS. Am J Respir Crit Care Med. 2021 May 1. PMID: 33929301.
• RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection.Huang HR, Cho SJ, Harris RM, Yang J, Bermejo S, Sharma L, Dela Cruz CS, Xu JF, Stout-Delgado HW. Am J Respir Cell Mol Biol. 2021 May. PMID: 33625952.
• PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology.Kim SH, Shin HJ, Yoon CM, Lee SW, Sharma L, Dela Cruz CS, Kang MJ. Am J Respir Cell Mol Biol. 2021 May. PMID: 33577398.
• Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis.Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Eur Respir J. 2021 Apr; 2021 Apr 15. PMID: 33093124.
• Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. medRxiv. 2021 Apr 3; 2021 Apr 3. PMID: 33300011.
• Increased SARS-CoV-2 Testing Capacity with Pooled Saliva Samples.Watkins AE, Fenichel EP, Weinberger DM, Vogels CBF, Brackney DE, Casanovas-Massana A, Campbell M, Fournier J, Bermejo S, Datta R, Dela Cruz CS, Farhadian SF, Iwasaki A, Ko AI, Grubaugh ND, Wyllie AL. Emerg Infect Dis. 2021 Apr. PMID: 33755009.
• Stability of SARS-CoV-2 RNA in Nonsupplemented Saliva.Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. Emerg Infect Dis. 2021 Apr. PMID: 33754989.
• Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults.Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Chest. 2021 Apr; 2020 Nov 18. PMID: 33217418.
• Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection.McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ Jr, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. PLoS One. 2021; 2021 Mar 31. PMID: 33788846.
• Association of Early Inflammation with Age and Asymptomatic Disease in COVID-19.Xie C, Li Q, Li L, Peng X, Ling Z, Xiao B, Feng J, Chen Z, Chang D, Xie L, Dela Cruz CS, Sharma L. J Inflamm Res. 2021; 2021 Mar 30. PMID: 33833543.
• SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity.Vogels CBF, Watkins AE, Harden CA, Brackney DE, Shafer J, Wang J, Caraballo C, Kalinich CC, Ott IM, Fauver JR, Kudo E, Lu P, Venkataraman A, Tokuyama M, Moore AJ, Muenker MC, Casanovas-Massana A, Fournier J, Bermejo S, Campbell M, Datta R, Nelson A, Dela Cruz CS, Ko AI, Iwasaki A, Krumholz HM, Matheus JD, Hui P, Liu C, Farhadian SF, Sikka R, Wyllie AL, Grubaugh ND. Med. 2021 Mar 12; 2020 Dec 26. PMID: 33521748.
• A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY: Learning From the Past, Looking to the Future.Lutchmansingh DD, Knauert MP, Antin-Ozerkis DE, Chupp G, Cohn L, Dela Cruz CS, Ferrante LE, Herzog EL, Koff J, Rochester CL, Ryu C, Singh I, Tickoo M, Winks V, Gulati M, Possick JD. Chest. 2021 Mar; 2020 Nov 4. PMID: 33159907.
• What Does Severe Acute Respiratory Syndrome Coronavirus 2 Mean for Global Pneumonia Prevention, Diagnosis, and Treatment?Awasthi S, Campbell H, Dela Cruz CS, Graham HR, Greenslade L, Jehan F, Zar HJ. Chest. 2021 Feb; 2020 Nov 1. PMID: 33144079.
• Editorial: Outsmarting the Host: How Bacterial Pathogens Modulate Immune Responses in the Lung.Borchers MT, Lau GW, Dela Cruz CS. Front Immunol. 2020; 2021 Jan 18. PMID: 33537037.
• Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, Casanovas-Massana A, Minasyan M, Farhadian S, Ko AI, Dela Cruz CS, Bosio CM. J Immunol. 2021 Jan 15; 2020 Dec 4. PMID: 33277388.
• JAK-inhibitor and type I interferon ability to produce favorable clinical outcomes in COVID-19 patients: a systematic review and meta-analysis.Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. BMC Infect Dis. 2021 Jan 11; 2021 Jan 11. PMID: 33430799.
• Disinfection of Pseudomonas aeruginosa from N95 respirators with ozone: a pilot study.Manning EP, Stephens MD, Dufresne S, Silver B, Gerbarg P, Gerbarg Z, Dela Cruz CS, Sharma L. BMJ Open Respir Res. 2021 Jan. PMID: 33431507.
• The kinetics of humoral response and its relationship with the disease severity in COVID-19.Ren L, Zhang L, Chang D, Wang J, Hu Y, Chen H, Guo L, Wu C, Wang C, Wang Y, Wang Y, Wang G, Yang S, Dela Cruz CS, Sharma L, Wang L, Zhang D, Wang J. Commun Biol. 2020 Dec 11; 2020 Dec 11. PMID: 33311543.
• Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2.Xiao X, Wang C, Chang D, Wang Y, Dong X, Jiao T, Zhao Z, Ren L, Dela Cruz CS, Sharma L, Lei X, Wang J. Front Immunol. 2020; 2020 Nov 25. PMID: 33324406.
• Circulating markers of angiogenesis and endotheliopathy in COVID-19.Pine AB, Meizlish ML, Goshua G, Chang CH, Zhang H, Bishai J, Bahel P, Patel A, Gbyli R, Kwan JM, Won CH, Price C, Dela Cruz CS, Halene S, van Dijk D, Hwa J, Lee AI, Chun HJ. Pulm Circ. 2020 Oct-Dec; 2020 Nov 25. PMID: 33282193.
• Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis.Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Am J Respir Crit Care Med. 2020 Nov 15. PMID: 32603604.
• International Perspective on the New 2019 American Thoracic Society/Infectious Diseases Society of America Community-Acquired Pneumonia Guideline: A Critical Appraisal by a Global Expert Panel.Pletz MW, Blasi F, Chalmers JD, Dela Cruz CS, Feldman C, Luna CM, Ramirez JA, Shindo Y, Stolz D, Torres A, Webb B, Welte T, Wunderink R, Aliberti S. Chest. 2020 Nov; 2020 Aug 25. PMID: 32858009.
• Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia.Gautam S, Cohen AJ, Stahl Y, Valda Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo MI, Dela Cruz CS. Thorax. 2020 Nov; 2020 Aug 21. PMID: 32826284.
• Does inflammation help during COVID-19?Sharma L, Chang D, Dela Cruz CS. ERJ Open Res. 2020 Oct; 2020 Oct 13. PMID: 33083436.
• Detection of SARS-CoV-2 RNA by multiplex RT-qPCR.Kudo E, Israelow B, Vogels CBF, Lu P, Wyllie AL, Tokuyama M, Venkataraman A, Brackney DE, Ott IM, Petrone ME, Earnest R, Lapidus S, Muenker MC, Moore AJ, Casanovas-Massana A, Omer SB, Dela Cruz CS, Farhadian SF, Ko AI, Grubaugh ND, Iwasaki A. PLoS Biol. 2020 Oct; 2020 Oct 7. PMID: 33027248.
• Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia.Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1; 2020 Aug 12. PMID: 32783617.
• Differential effects of the Akt pathway on the internalization of Klebsiella by lung epithelium and macrophages.Chang D, Feng J, Liu H, Liu W, Sharma L, Dela Cruz CS. Innate Immun. 2020 Oct; 2020 Aug 6. PMID: 32762278.
• Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT-qPCR primer-probe sets.Vogels CBF, Brito AF, Wyllie AL, Fauver JR, Ott IM, Kalinich CC, Petrone ME, Casanovas-Massana A, Catherine Muenker M, Moore AJ, Klein J, Lu P, Lu-Culligan A, Jiang X, Kim DJ, Kudo E, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Tokuyama M, Venkataraman A, Weizman OE, Wong P, Yang Y, Cheemarla NR, White EB, Lapidus S, Earnest R, Geng B, Vijayakumar P, Odio C, Fournier J, Bermejo S, Farhadian S, Dela Cruz CS, Iwasaki A, Ko AI, Landry ML, Foxman EF, Grubaugh ND. Nat Microbiol. 2020 Oct; 2020 Jul 10. PMID: 32651556.
• Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2.Wyllie AL, Fournier J, Casanovas-Massana A, Campbell M, Tokuyama M, Vijayakumar P, Warren JL, Geng B, Muenker MC, Moore AJ, Vogels CBF, Petrone ME, Ott IM, Lu P, Venkataraman A, Lu-Culligan A, Klein J, Earnest R, Simonov M, Datta R, Handoko R, Naushad N, Sewanan LR, Valdez J, White EB, Lapidus S, Kalinich CC, Jiang X, Kim DJ, Kudo E, Linehan M, Mao T, Moriyama M, Oh JE, Park A, Silva J, Song E, Takahashi T, Taura M, Weizman OE, Wong P, Yang Y, Bermejo S, Odio CD, Omer SB, Dela Cruz CS, Farhadian S, Martinello RA, Iwasaki A, Grubaugh ND, Ko AI. N Engl J Med. 2020 Sep 24; 2020 Aug 28. PMID: 32857487.
• Pooling saliva to increase SARS-CoV-2 testing capacity.Watkins AE, Fenichel EP, Weinberger DM, Vogels CBF, Brackney DE, Casanovas-Massana A, Campbell M, Fournier J, Bermejo S, Datta R, Dela Cruz CS, Farhadian SF, Iwasaki A, Ko AI, Grubaugh ND, Wyllie AL. medRxiv. 2020 Sep 3; 2020 Sep 3. PMID: 32909003.
• Host tolerance contributes to persistent viral shedding in COVID-19.Chang D, Chen Z, Wang FS, Xie LX, Dela Cruz CS, Sharma L, Qin EQ. EClinicalMedicine. 2020 Sep; 2020 Sep 15. PMID: 32954242.
• Persistent Viral Presence Determines the Clinical Course of the Disease in COVID-19.Chang D, Zhao P, Zhang D, Dong JH, Xu Z, Yang G, Li BY, Liu HX, Li BA, Qin CF, Peng XH, Wang FS, Xie LX, Chen Z, Dela Cruz CS, Sharma L, Qin EQ. J Allergy Clin Immunol Pract. 2020 Sep; 2020 Jun 20. PMID: 32574840.
• JAK-Inhibitor and Type I Interferon Ability to Produce Favorable Clinical Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis.Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. Res Sq. 2020 Aug 26; 2020 Aug 26. PMID: 32869016.
• Rapid decline of seasonal influenza during the outbreak of COVID-19.Young G, Peng X, Rebeza A, Bermejo S, De C, Sharma L, Dela Cruz CS. ERJ Open Res. 2020 Jul; 2020 Aug 17. PMID: 32832527.
• SARS-CoV-2 Transmission and the Risk of Aerosol-Generating Procedures.Pasnick S, Carlos WG, Dela Cruz CS, Gross JE, Garrison G, Jamil S. Am J Respir Crit Care Med. 2020 Aug 15. PMID: 32795140.
• Janus Kinase-Inhibitor and Type I Interferon Ability to Produce Favorable Clinical Outcomes in COVID-19 Patients: A Systematic Review and Meta-Analysis.Walz L, Cohen AJ, Rebaza AP, Vanchieri J, Slade MD, Dela Cruz CS, Sharma L. medRxiv. 2020 Aug 11; 2020 Aug 11. PMID: 32817985.
• Simply saliva: stability of SARS-CoV-2 detection negates the need for expensive collection devices.Ott IM, Strine MS, Watkins AE, Boot M, Kalinich CC, Harden CA, Vogels CBF, Casanovas-Massana A, Moore AJ, Muenker MC, Nakahata M, Tokuyama M, Nelson A, Fournier J, Bermejo S, Campbell M, Datta R, Dela Cruz CS, Farhadian SF, Ko AI, Iwasaki A, Grubaugh ND, Wilen CB, Wyllie AL. medRxiv. 2020 Aug 4; 2020 Aug 4. PMID: 32793924.
• Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ, Dela Cruz CS, Dumont A, Halene S, Hwa J, Koff J, Menninger H, Neparidze N, Price C, Siner JM, Tormey C, Rinder HM, Chun HJ, Lee AI. Lancet Haematol. 2020 Aug; 2020 Jun 30. PMID: 32619411.
• Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19).Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, Dela Cruz CS, Wang Y, Wu C, Xiao Y, Zhang L, Han L, Dang S, Xu Y, Yang QW, Xu SY, Zhu HD, Xu YC, Jin Q, Sharma L, Wang L, Wang J. Clin Infect Dis. 2020 Jul 28. PMID: 32198501.