Publications

2023

Imaging the brain's immune response to alcohol with [(11)C]PBR28 TSPO Positron Emission Tomography.Raval NR, Angarita G, Matuskey D, Miller R, Drake LR, Kapinos M, Nabulsi N, Huang Y, Carson RE, O'Malley SS, Cosgrove KP, Hillmer AT. Mol Psychiatry. 2023 Aug 2; 2023 Aug 2. PMID: 37532797.
Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs.Zakiniaeiz Y, Peltier MR, Mineur YS, Gueorguieva R, Picciotto MR, Petrakis I, Cosgrove KP, McKee SA. J Womens Health (Larchmt). 2023 Aug. PMID: 37585509.
Sex steroid hormone levels associated with dopamine D(2/3) receptor availability in people who smoke cigarettes.Zakiniaeiz Y, Gueorguieva R, Peltier MR, Verplaetse TL, Roberts W, McKee SA, Cosgrove KP. Front Behav Neurosci. 2023; 2023 Jun 9. PMID: 37358969.
Clustering of KOR PET images separates people with AUD into distinct responses to naltrexone.Hoye J, Key J, de Laat B, Cosgrove KP, Krishnan-Sarin S, Papademetris X, Morris ED. Brain Imaging Behav. 2023 Jun; 2023 Jan 25. PMID: 36695971.
Lower Dopamine D2/3 Receptor Availability is Associated With Worse Verbal Learning and Memory in People Who Smoke Cigarettes.Zakiniaeiz Y, Gueorguieva R, Peltier MR, Roberts W, Verplaetse TL, Burke C, Morris ED, McKee SA, Cosgrove KP. Nicotine Tob Res. 2023 Apr 6. PMID: 36107715.
Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[(18)F]flubatine PET study.Calakos KC, Hillmer AT, Anderson JM, LeVasseur B, Baldassarri SR, Angarita GA, Matuskey D, Kapinos M, Zheng MQ, Huang Y, Cosgrove KP. Neuropsychopharmacology. 2023 Mar; 2023 Jan 21. PMID: 36681758.

2022

Systemic inflammation enhances stimulant-induced striatal dopamine elevation in tobacco smokers.Zakiniaeiz Y, Hoye J, Ryan Petrulli J, LeVasseur B, Stanley G, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Chen MK, Matuskey D, Barron DS, Kelmendi B, Fulbright RK, Hampson M, Cosgrove KP, Morris ED. Brain Behav Immun. 2022 Nov; 2022 Sep 1. PMID: 36058419.
Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response.Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Tob Res. 2022 Oct 17. PMID: 35100429.
A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Bonomi RE, Girgenti M, Krystal JH, Cosgrove KP. Complex Psychiatry. 2022 Sep; 2022 Mar 15. PMID: 36545044.
Why language matters in alcohol research: Reducing stigma.Shi HD, McKee SA, Cosgrove KP. Alcohol Clin Exp Res. 2022 Jun; 2022 Jun 21. PMID: 35727299.
Multimodal neuroimaging of metabotropic glutamate 5 receptors and functional connectivity in alcohol use disorder.Smart K, Worhunsky PD, Scheinost D, Angarita GA, Esterlis I, Carson RE, Krystal JH, O'Malley SS, Cosgrove KP, Hillmer AT. Alcohol Clin Exp Res. 2022 May; 2022 Apr 21. PMID: 35342968.
Recently Abstinent Smokers Exhibit Mood-Associated Dopamine Dysfunction in the Ventral Striatum Compared to Nonsmokers: A [11C]-(+)-PHNO PET Study.Calakos KC, Hillmer AT, Angarita GA, Baldassarri SR, Najafzadeh S, Emery PR, Matuskey D, Huang Y, Cosgrove KP. Nicotine Tob Res. 2022 Mar 26. PMID: 34628508.
Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.Calakos KC, Rusowicz A, Pittman B, Gallezot JD, Potenza MN, Cosgrove KP, Matuskey D. Neurosci Lett. 2022 Feb 6; 2022 Jan 17. PMID: 35051435.

2021

Imaging brain cortisol regulation in PTSD with a target for 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Hillmer AT, Rusowicz A, Nabulsi N, Matuskey D, Angarita GA, Najafzadeh S, Kapinos M, Southwick SM, Krystal JH, Carson RE, Huang Y, Cosgrove KP. J Clin Invest. 2021 Oct 15. PMID: 34651587.
Assessment of transient dopamine responses to smoked cannabis.Calakos KC, Liu H, Lu Y, Anderson JM, Matuskey D, Nabulsi N, Ye Y, Skosnik PD, D'Souza DC, Morris ED, Cosgrove KP, Hillmer AT. Drug Alcohol Depend. 2021 Oct 1; 2021 Jul 29. PMID: 34399137.
PET Imaging Estimates of Regional Acetylcholine Concentration Variation in Living Human Brain.Smart K, Naganawa M, Baldassarri SR, Nabulsi N, Ropchan J, Najafzadeh S, Gao H, Navarro A, Barth V, Esterlis I, Cosgrove KP, Huang Y, Carson RE, Hillmer AT. Cereb Cortex. 2021 May 10. PMID: 33442731.
Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders.Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Neuropharmacology. 2021 Apr 1; 2021 Feb 16. PMID: 33600842.
FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study.Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. J Nucl Cardiol. 2021 Apr; 2019 May 9. PMID: 31073848.
Nondisplaceable Binding Is a Potential Confounding Factor in (11)C-PBR28 Translocator Protein PET Studies.Laurell GL, Plavén-Sigray P, Jucaite A, Varrone A, Cosgrove KP, Svarer C, Knudsen GM, Ogden RT, Zanderigo F, Cervenka S, Hillmer AT, Schain M. J Nucl Med. 2021 Mar; 2020 Jul 17. PMID: 32680926.
Acute neuroimmune stimulation impairs verbal memory in adults: A PET brain imaging study.Woodcock EA, Hillmer AT, Sandiego CM, Maruff P, Carson RE, Cosgrove KP, Pietrzak RH. Brain Behav Immun. 2021 Jan; 2020 Sep 28. PMID: 33002632.
Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence.Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley SSO, Cosgrove KP. Neuropsychopharmacology. 2021 Jan; 2020 Sep 12. PMID: 32919411.
Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Verplaetse TL, Cosgrove KP, Tanabe J, McKee SA. J Neurosci Res. 2021 Jan; 2020 Apr 24. PMID: 32333417.

2020

Designing Neuroimaging Studies to Help Inform the Clinical Treatment of Addiction.Zakiniaeiz Y, Cosgrove KP. Biol Psychiatry. 2020 Nov 15. PMID: 33092691.
Accuracy of arterial [(18)F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. J Nucl Cardiol. 2020 Oct; 2020 Feb 10. PMID: 32043239.
Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study.Hillmer AT, Matuskey D, Huang Y, Nabulsi N, Ropchan J, Carson RE, O'Malley SS, Cosgrove KP. J Nucl Med. 2020 Aug; 2020 Jan 31. PMID: 32005773.
PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies.Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman RS, Carson RE, Krystal JH, Pietrzak RH, Cosgrove KP. Nat Commun. 2020 May 12; 2020 May 12. PMID: 32398677.
First in-human PET study and kinetic evaluation of [(18)F]AS2471907 for imaging 11β-hydroxysteroid dehydrogenase type 1.Bhatt S, Nabulsi NB, Li S, Cai Z, Matuskey D, Bini J, Najafzadeh S, Kapinos M, Ropchan JR, Carson RE, Cosgrove KP, Huang Y, Hillmer AT. J Cereb Blood Flow Metab. 2020 Apr; 2019 Mar 21. PMID: 30895878.
Quantification of [(11)C]PBR28 data after systemic lipopolysaccharide challenge.Woodcock EA, Schain M, Cosgrove KP, Hillmer AT. EJNMMI Res. 2020 Mar 12; 2020 Mar 12. PMID: 32166497.
Sex and the dopaminergic system: Insights from addiction studies.Woodcock EA, Zakiniaeiz Y, Morris ED, Cosgrove KP. Handb Clin Neurol. 2020. PMID: 33008522.

2019

Sex differences in amphetamine-induced dopamine release in the dorsolateral prefrontal cortex of tobacco smokers.Zakiniaeiz Y, Hillmer AT, Matuskey D, Nabulsi N, Ropchan J, Mazure CM, Picciotto MR, Huang Y, McKee SA, Morris ED, Cosgrove KP. Neuropsychopharmacology. 2019 Dec; 2019 Jul 3. PMID: 31269510.
Effects of age, BMI and sex on the glial cell marker TSPO - a multicentre [(11)C]PBR28 HRRT PET study.Tuisku J, Plavén-Sigray P, Gaiser EC, Airas L, Al-Abdulrasul H, Brück A, Carson RE, Chen MK, Cosgrove KP, Ekblad L, Esterlis I, Farde L, Forsberg A, Halldin C, Helin S, Kosek E, Lekander M, Lindgren N, Marjamäki P, Rissanen E, Sucksdorff M, Varrone A, Collste K, Gallezot JD, Hillmer A, Huang Y, Höglund CO, Johansson J, Jucaite A, Lampa J, Nabulsi N, Pittman B, Sandiego CM, Stenkrona P, Rinne J, Matuskey D, Cervenka S. Eur J Nucl Med Mol Imaging. 2019 Oct; 2019 Jul 30. PMID: 31363804.
Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study.Verplaetse TL, Moore KE, Pittman BP, Roberts W, Oberleitner LM, Peltier MKR, Hacker R, Cosgrove KP, McKee SA. Nicotine Tob Res. 2019 Sep 19. PMID: 30239953.
Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review.Woodcock EA, Hillmer AT, Mason GF, Cosgrove KP. Mol Neuropsychiatry. 2019 Jun; 2019 May 9. PMID: 31312635.
Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex.Liu H, Zakiniaeiz Y, Cosgrove KP, Morris ED. Brain Imaging Behav. 2019 Apr. PMID: 29071465.
Sex differences in stress-related alcohol use.Peltier MR, Verplaetse TL, Mineur YS, Petrakis IL, Cosgrove KP, Picciotto MR, McKee SA. Neurobiol Stress. 2019 Feb; 2019 Feb 8. PMID: 30949562.

2018

Sex differences in the nicotinic acetylcholine and dopamine receptor systems underlying tobacco smoking addiction.Verplaetse TL, Morris ED, McKee SA, Cosgrove KP. Curr Opin Behav Sci. 2018 Oct; 2018 Apr 26. PMID: 31341936.
Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study.Moran-Santa Maria MM, Vanderweyen DC, Camp CC, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Nicotine Tob Res. 2018 Jun 7. PMID: 29059410.
The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [(11)C]FLB457 PET Study.Sandiego CM, Matuskey D, Lavery M, McGovern E, Huang Y, Nabulsi N, Ropchan J, Picciotto MR, Morris ED, McKee SA, Cosgrove KP. Neuropsychopharmacology. 2018 Apr; 2017 Sep 25. PMID: 28944773.
Use of Electronic Cigarettes Leads to Significant Beta2-Nicotinic Acetylcholine Receptor Occupancy: Evidence From a PET Imaging Study.Baldassarri SR, Hillmer AT, Anderson JM, Jatlow P, Nabulsi N, Labaree D, Cosgrove KP, O'Malley SS, Eissenberg T, Krishnan-Sarin S, Esterlis I. Nicotine Tob Res. 2018 Mar 6. PMID: 28460123.
Evaluation of (-)-[(18) F]Flubatine-specific binding: Implications for reference region approaches.Bhatt S, Hillmer AT, Nabulsi N, Matuskey D, Lim K, Lin SF, Esterlis I, Carson RE, Huang Y, Cosgrove KP. Synapse. 2018 Mar; 2017 Nov 17. PMID: 29105121.
Intersection of stress and gender in association with transitions in past year DSM-5 substance use disorder diagnoses in the United States.Verplaetse TL, Moore KE, Pittman BP, Roberts W, Oberleitner LM, Smith PH, Cosgrove KP, McKee SA. Chronic Stress (Thousand Oaks). 2018 Jan-Dec; 2018 Jan 17. PMID: 29527591.

2017

Mechanisms Underlying Sex Differences in Cannabis Use.Calakos KC, Bhatt S, Foster DW, Cosgrove KP. Curr Addict Rep. 2017 Dec; 2017 Oct 19. PMID: 29503790.
Microglial depletion and activation: A [(11)C]PBR28 PET study in nonhuman primates.Hillmer AT, Holden D, Fowles K, Nabulsi N, West BL, Carson RE, Cosgrove KP. EJNMMI Res. 2017 Dec; 2017 Jul 24. PMID: 28741281.
In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.Hillmer AT, Sandiego CM, Hannestad J, Angarita GA, Kumar A, McGovern EM, Huang Y, O'Connor KC, Carson RE, O'Malley SS, Cosgrove KP. Mol Psychiatry. 2017 Dec; 2017 Feb 28. PMID: 28242869.
Does Telescoping Exist in Male and Female Gamblers? Does It Matter?Zakiniaeiz Y, Cosgrove KP, Mazure CM, Potenza MN. Front Psychol. 2017; 2017 Sep 5. PMID: 28928697.
Cholinergic activity and levodopa-induced dyskinesia: a multitracer molecular imaging study.Brumberg J, Küsters S, Al-Momani E, Marotta G, Cosgrove KP, van Dyck CH, Herrmann K, Homola GA, Pezzoli G, Buck AK, Volkmann J, Samnick S, Isaias IU. Ann Clin Transl Neurol. 2017 Sep; 2017 Aug 11. PMID: 28904985.
PET imaging of α(7) nicotinic acetylcholine receptors: a comparative study of [(18)F]ASEM and [(18)F]DBT-10 in nonhuman primates, and further evaluation of [(18)F]ASEM in humans.Hillmer AT, Li S, Zheng MQ, Scheunemann M, Lin SF, Nabulsi N, Holden D, Pracitto R, Labaree D, Ropchan J, Teodoro R, Deuther-Conrad W, Esterlis I, Cosgrove KP, Brust P, Carson RE, Huang Y. Eur J Nucl Med Mol Imaging. 2017 Jun; 2017 Jan 24. PMID: 28120003.
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking.Wang S, Kim S, Cosgrove KP, Morris ED. Neuroimage. 2017 Feb 1; 2016 Oct 13. PMID: 27743899.

2016

Elevated Dopamine D(2/3) Receptor Availability in Obese Individuals: A PET Imaging Study with [(11)C](+)PHNO.Gaiser EC, Gallezot JD, Worhunsky PD, Jastreboff AM, Pittman B, Kantrovitz L, Angarita GA, Cosgrove KP, Potenza MN, Malison RT, Carson RE, Matuskey D. Neuropsychopharmacology. 2016 Dec; 2016 Jul 4. PMID: 27374277.
Imaging of cerebral α4β2* nicotinic acetylcholine receptors with (-)-[(18)F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain.Hillmer AT, Esterlis I, Gallezot JD, Bois F, Zheng MQ, Nabulsi N, Lin SF, Papke RL, Huang Y, Sabri O, Carson RE, Cosgrove KP. Neuroimage. 2016 Nov 1; 2016 Jul 15. PMID: 27426839.
CHRNA4 and ANKK1 Polymorphisms Influence Smoking-Induced Nicotinic Acetylcholine Receptor Upregulation.Esterlis I, Hillmer AT, Bois F, Pittman B, McGovern E, O'Malley SS, Picciotto MR, Yang BZ, Gelernter J, Cosgrove KP. Nicotine Tob Res. 2016 Sep; 2016 Mar 31. PMID: 27611310.
A Need for Longitudinal Studies in the Addiction Field.Cosgrove KP. Biol Psychiatry. 2016 Aug 1. PMID: 27402471.
Balance of the Sexes: Addressing Sex Differences in Preclinical Research.Zakiniaeiz Y, Cosgrove KP, Potenza MN, Mazure CM. Yale J Biol Med. 2016 Jun; 2016 Jun 27. PMID: 27354851.
Nicotine and Nicotine Abstinence Do Not Interfere with GABAA Receptor Neuroadaptations During Alcohol Abstinence.Hillmer AT, Kloczynski T, Sandiego CM, Pittman B, Anderson JM, Labaree D, Gao H, Huang Y, Deluliis G, O'Malley SS, Carson RE, Cosgrove KP. Alcohol Clin Exp Res. 2016 Apr; 2016 Mar 12. PMID: 26971694.

2015

How Imaging Glutamate, γ-Aminobutyric Acid, and Dopamine Can Inform the Clinical Treatment of Alcohol Dependence and Withdrawal.Hillmer AT, Mason GF, Fucito LM, O'Malley SS, Cosgrove KP. Alcohol Clin Exp Res. 2015 Dec; 2015 Oct 28. PMID: 26510169.
Imaging robust microglial activation after lipopolysaccharide administration in humans with PET.Sandiego CM, Gallezot JD, Pittman B, Nabulsi N, Lim K, Lin SF, Matuskey D, Lee JY, O'Connor KC, Huang Y, Carson RE, Hannestad J, Cosgrove KP. Proc Natl Acad Sci U S A. 2015 Oct 6; 2015 Sep 18. PMID: 26385967.
A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.Matuskey D, Gaiser EC, Gallezot JD, Angarita GA, Pittman B, Nabulsi N, Ropchan J, MaCleod P, Cosgrove KP, Ding YS, Potenza MN, Carson RE, Malison RT. Drug Alcohol Depend. 2015 Sep 1; 2015 Jun 30. PMID: 26164205.
Evaluation of [(18)F]-(-)-norchlorofluorohomoepibatidine ([(18)F]-(-)-NCFHEB) as a PET radioligand to image the nicotinic acetylcholine receptors in non-human primates.Bois F, Gallezot JD, Zheng MQ, Lin SF, Esterlis I, Cosgrove KP, Carson RE, Huang Y. Nucl Med Biol. 2015 Jun; 2014 Aug 8. PMID: 25858513.
Targeting the noradrenergic system for gender-sensitive medication development for tobacco dependence.Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Nicotine Tob Res. 2015 Apr; 2015 Mar 11. PMID: 25762760.
Systematic and meta-analytic review of research examining the impact of menstrual cycle phase and ovarian hormones on smoking and cessation.Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, Gray KM, Mazure CM, Wetherington CL, McKee SA. Nicotine Tob Res. 2015 Apr. PMID: 25762750.
Opposing relationships of BMI with BOLD and dopamine D2/3 receptor binding potential in the dorsal striatum.Cosgrove KP, Veldhuizen MG, Sandiego CM, Morris ED, Small DM. Synapse. 2015 Apr; 2015 Mar 11. PMID: 25664726.
A case series on the heightened autonomic response due to guanfacine and amphetamine interaction.Gaiser EC, Matuskey D, Perkins E, D'Amico C, Abdelghany O, McKee SA, Cosgrove KP. J Clin Psychopharmacol. 2015 Apr. PMID: 25634160.
Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PET.Sandiego CM, Gallezot JD, Lim K, Ropchan J, Lin SF, Gao H, Morris ED, Cosgrove KP. J Cereb Blood Flow Metab. 2015 Mar 31; 2015 Mar 31. PMID: 25564239.
Comparison of standardized uptake values with volume of distribution for quantitation of [(11)C]PBR28 brain uptake.Yoder KK, Territo PR, Hutchins GD, Hannestad J, Morris ED, Gallezot JD, Normandin MD, Cosgrove KP. Nucl Med Biol. 2015 Mar; 2014 Nov 15. PMID: 25487553.
Imaging Tobacco Smoking with PET and SPECT.Cosgrove KP, Esterlis I, Sandiego C, Petrulli R, Morris ED. Curr Top Behav Neurosci. 2015. PMID: 25638332.

2014

Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Proc Natl Acad Sci U S A. 2014 Dec 16; 2014 Dec 1. PMID: 25453062.
Sex differences in the brain's dopamine signature of cigarette smoking.Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. J Neurosci. 2014 Dec 10. PMID: 25505336.
Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys.Gallezot JD, Esterlis I, Bois F, Zheng MQ, Lin SF, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Synapse. 2014 Nov; 2014 Jul 28. PMID: 25043426.
In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia.Esterlis I, Ranganathan M, Bois F, Pittman B, Picciotto MR, Shearer L, Anticevic A, Carlson J, Niciu MJ, Cosgrove KP, D'Souza DC. Biol Psychiatry. 2014 Sep 15; 2013 Nov 13. PMID: 24360979.
Voxelwise lp-ntPET for detecting localized, transient dopamine release of unknown timing: sensitivity analysis and application to cigarette smoking in the PET scanner.Kim SJ, Sullivan JM, Wang S, Cosgrove KP, Morris ED. Hum Brain Mapp. 2014 Sep; 2014 Apr 3. PMID: 24700424.
Nicotinic acetylcholine receptor density in cognitively intact subjects at an early stage of Parkinson's disease.Isaias IU, Spiegel J, Brumberg J, Cosgrove KP, Marotta G, Oishi N, Higuchi T, Küsters S, Schiller M, Dillmann U, van Dyck CH, Buck A, Herrmann K, Schloegl S, Volkmann J, Lassmann M, Fassbender K, Lorenz R, Samnick S. Front Aging Neurosci. 2014; 2014 Aug 14. PMID: 25177294.
How to design PET experiments to study neurochemistry: application to alcoholism.Morris ED, Lucas MV, Petrulli JR, Cosgrove KP. Yale J Biol Med. 2014 Mar; 2014 Mar 5. PMID: 24600335.
Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.Gallezot JD, Kloczynski T, Weinzimmer D, Labaree D, Zheng MQ, Lim K, Rabiner EA, Ridler K, Pittman B, Huang Y, Carson RE, Morris ED, Cosgrove KP. Neuropsychopharmacology. 2014 Mar; 2013 Oct 15. PMID: 24220025.

2013

Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography.Hannestad JO, Cosgrove KP, DellaGioia NF, Perkins E, Bois F, Bhagwagar Z, Seibyl JP, McClure-Begley TD, Picciotto MR, Esterlis I. Biol Psychiatry. 2013 Nov 15; 2013 Jun 14. PMID: 23773793.
Creating dynamic images of short-lived dopamine fluctuations with lp-ntPET: dopamine movies of cigarette smoking.Morris ED, Kim SJ, Sullivan JM, Wang S, Normandin MD, Constantinescu CC, Cosgrove KP. J Vis Exp. 2013 Aug 6; 2013 Aug 6. PMID: 23963311.
Limitations of SRTM, Logan graphical method, and equilibrium analysis for measuring transient dopamine release with [(11)C]raclopride PET.Sullivan JM, Kim SJ, Cosgrove KP, Morris ED. Am J Nucl Med Mol Imaging. 2013; 2013 Apr 9. PMID: 23638336.
Effect of a nicotine vaccine on nicotine binding to β2*-nicotinic acetylcholine receptors in vivo in human tobacco smokers.Esterlis I, Hannestad JO, Perkins E, Bois F, D'Souza DC, Tyndale RF, Seibyl JP, Hatsukami DM, Cosgrove KP, O'Malley SS. Am J Psychiatry. 2013 Apr. PMID: 23429725.
In vivo evaluation of [(123)I]MNI-420: a novel single photon emission computed tomography radiotracer for imaging of adenosine 2A receptors in brain.Tavares AA, Batis J, Barret O, Alagille D, Vala C, Kudej G, Koren A, Cosgrove KP, Nice K, Kordower JH, Seibyl J, Tamagnan GD. Nucl Med Biol. 2013 Apr; 2013 Jan 16. PMID: 23332393.
Test-retest reproducibility of [11C]-(+)-propyl-hexahydro-naphtho-oxazin positron emission tomography using the bolus plus constant infusion paradigm.Lee DE, Gallezot JD, Zheng MQ, Lim K, Ding YS, Huang Y, Carson RE, Morris ED, Cosgrove KP. Mol Imaging. 2013 Mar-Apr. PMID: 23415395.
Sex-specific differences in GABA(A) -benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving.Esterlis I, McKee SA, Kirk K, Lee D, Bois F, Stiklus SM, Seibyl JP, Krishnan-Sarin S, O'Malley SS, Staley JK, Cosgrove KP. Addict Biol. 2013 Mar; 2012 Feb 21. PMID: 22353491.
Imaging changes in synaptic acetylcholine availability in living human subjects.Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. J Nucl Med. 2013 Jan; 2012 Nov 15. PMID: 23160789.
Kinetic modeling and occupancy measures of the norepinephrine transporters in baboons using single photon emission computed tomography with (123)I-INER.Tavares AA, Barret O, Batis J, Alagille D, Koren A, Papin C, Kudej G, Nice K, Kordower JH, Cosgrove KP, Kloczynski T, Brenner E, Seibyl J, Tamagnan G. Synapse. 2013 Jan; 2012 Oct 31. PMID: 23042643.

2012

Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates.Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP. Neuroimage. 2012 Oct 15; 2012 Jul 6. PMID: 22776451.
Persistent β2*-nicotinic acetylcholinergic receptor dysfunction in major depressive disorder.Saricicek A, Esterlis I, Maloney KH, Mineur YS, Ruf BM, Muralidharan A, Chen JI, Cosgrove KP, Kerestes R, Ghose S, Tamminga CA, Pittman B, Bois F, Tamagnan G, Seibyl J, Picciotto MR, Staley JK, Bhagwagar Z. Am J Psychiatry. 2012 Aug. PMID: 22772158.
Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers.Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O'Malley SS. Arch Gen Psychiatry. 2012 Apr. PMID: 22474108.

2011

Assessing the sensitivity of [¹¹C]p943, a novel 5-HT1B radioligand, to endogenous serotonin release.Cosgrove KP, Kloczynski T, Nabulsi N, Weinzimmer D, Lin SF, Staley JK, Bhagwagar Z, Carson RE. Synapse. 2011 Oct; 2011 May 3. PMID: 21484884.
Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Biol Psychiatry. 2011 Sep 15; 2011 Jun 17. PMID: 21683344.
Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence.Cosgrove KP, Esterlis I, Mason GF, Bois F, O'Malley SS, Krystal JH. Neuropharmacology. 2011 Jun; 2011 Jan 27. PMID: 21276806.
Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler.Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Int J Neuropsychopharmacol. 2011 Apr; 2010 Oct 29. PMID: 21029513.

2010

Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study.Cosgrove KP, Tellez-Jacques K, Pittman B, Petrakis I, Baldwin RM, Tamagnan G, Seibyl J, Kosten T, Staley JK. Psychiatry Res. 2010 Dec 30; 2010 Nov 3. PMID: 21050726.
Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates.Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH, Staley JK. Synapse. 2010 Sep. PMID: 20340174.
Quantification of smoking-induced occupancy of beta2-nicotinic acetylcholine receptors: estimation of nondisplaceable binding.Esterlis I, Cosgrove KP, Batis JC, Bois F, Stiklus SM, Perkins E, Seibyl JP, Carson RE, Staley JK. J Nucl Med. 2010 Aug; 2010 Jul 21. PMID: 20660383.
SPECT imaging with the serotonin transporter radiotracer [123I]p ZIENT in nonhuman primate brain.Cosgrove KP, Staley JK, Baldwin RM, Bois F, Plisson C, Al-Tikriti MS, Seibyl JP, Goodman MM, Tamagnan GD. Nucl Med Biol. 2010 Jul; 2010 May 6. PMID: 20610163.
Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers.Cosgrove KP, Esterlis I, McKee S, Bois F, Alagille D, Tamagnan GD, Seibyl JP, Krishnan-Sarin S, Staley JK. Nicotine Tob Res. 2010 May; 2010 Apr 6. PMID: 20371741.
SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals.Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. Drug Alcohol Depend. 2010 Apr 1; 2010 Jan 13. PMID: 20074869.
Imaging receptor changes in human drug abusers.Cosgrove KP. Curr Top Behav Neurosci. 2010. PMID: 21161754.

2009

GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression.Esterlis I, Cosgrove KP, Batis JC, Bois F, Kloczynski TA, Stiklus SM, Perry E, Tamagnan GD, Seibyl JP, Makuch R, Krishnan-Sarin S, O'Malley S, Staley JK. Synapse. 2009 Dec. PMID: 19642218.
Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking.Cosgrove KP, Krantzler E, Frohlich EB, Stiklus S, Pittman B, Tamagnan GD, Baldwin RM, Bois F, Seibyl JP, Krystal JH, O'Malley SS, Staley JK. Neuropsychopharmacology. 2009 Sep; 2009 May 13. PMID: 19440191.
Age-related decline in nicotinic receptor availability with [(123)I]5-IA-85380 SPECT.Mitsis EM, Cosgrove KP, Staley JK, Bois F, Frohlich EB, Tamagnan GD, Estok KM, Seibyl JP, van Dyck CH. Neurobiol Aging. 2009 Sep; 2008 Feb 1. PMID: 18242781.
beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking.Cosgrove KP, Batis J, Bois F, Maciejewski PK, Esterlis I, Kloczynski T, Stiklus S, Krishnan-Sarin S, O'Malley S, Perry E, Tamagnan G, Seibyl JP, Staley JK. Arch Gen Psychiatry. 2009 Jun. PMID: 19487632.