2024
Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity
Zhang T, Yu W, Cheng X, Yeung J, Ahumada V, Norris P, Pearson M, Yang X, van Deursen W, Halcovich C, Nassar A, Vesely M, Zhang Y, Zhang J, Ji L, Flies D, Liu L, Langermann S, LaRochelle W, Humphrey R, Zhao D, Zhang Q, Zhang J, Gu R, Schalper K, Sanmamed M, Chen L. Up-regulated PLA2G10 in cancer impairs T cell infiltration to dampen immunity. Science Immunology 2024, 9: eadh2334. PMID: 38669316, DOI: 10.1126/sciimmunol.adh2334.Peer-Reviewed Original ResearchConceptsT cell infiltrationT cell exclusionT cellsResistance to anti-PD-1 immunotherapyPoor T-cell infiltrationAnti-PD-1 immunotherapyImmunogenic mouse tumorsT cell mobilizationHuman cancer tissuesTherapeutic immunotherapyCancer immunotherapyMouse tumorsChemokine systemImmunotherapyTumor tissuesImpaired infiltrationTumorLipid metabolitesHuman cancersCancer tissuesInfiltrationA2 groupCancerPLA2G10Up-regulated
2022
Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept
Tang S, Holle J, Lesslar O, Teo C, Sughrue M, Yeung J. Improving quality of life post-tumor craniotomy using personalized, parcel-guided TMS: safety and proof of concept. Journal Of Neuro-Oncology 2022, 160: 413-422. PMID: 36308593, DOI: 10.1007/s11060-022-04160-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainCraniotomyHumansNeoplasmsQuality of LifeTranscranial Magnetic StimulationTreatment OutcomeConceptsRepetitive transcranial magnetic stimulationNeuro-cognitive dysfunctionRTMS treatmentBeck Depression InventoryFunctional deficitsNeurological disordersDepression InventoryPost-operative depressionTranscranial magnetic stimulationNeuro-cognitive deficitsNeuro-cognitive functionsMultiple cortical targetsFunctional connectivity approachNon-invasive toolEuroQol qualityNeuropsychiatric questionnaireResultsNine patientsAdverse eventsRetrospective reviewSurgical removalTMS treatmentCortical targetsShort-term memory difficultiesBrain tumorsDepressive symptoms