Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis
Cho C, Mukherjee R, Peck AR, Sun Y, McBrearty N, Katlinski KV, Gui J, Govindaraju PK, Puré E, Rui H, Fuchs SY. Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis. Oncogene 2020, 39: 6129-6137. PMID: 32807917, PMCID: PMC7502515, DOI: 10.1038/s41388-020-01424-7.Peer-Reviewed Original ResearchConceptsCancer-associated fibroblastsFibroblast activation proteinType I interferon receptorTumor growthPancreatic ductal adenocarcinoma tumorsInterferon receptorKnockdown of Smad7Human colorectal cancerGrowth of tumorsSA miceColorectal cancerAdenocarcinoma tumorsSolid tumorsIFNAR1 downregulationGenetic ablationTumorsActivation proteinElevated levelsExtracellular matrixInverse correlationMiceStromagenesisIFNAR1IFNAR1 chainFAP levelsFibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells
Cho C, Horzempa C, Longo CM, Peters DM, Jones DM, McKeown-Longo PJ. Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells. Journal Of Cancer 2020, 11: 3099-3105. PMID: 32231714, PMCID: PMC7097952, DOI: 10.7150/jca.39771.Peer-Reviewed Original ResearchType III domainExtracellular matrixLung cancer cellsFibronectin type III domainTumor-associated extracellular matrixCancer cellsFibronectin-rich extracellular matrixTLR4-dependent inflammatory responsesRich extracellular matrixFirst Type III domainIL-8Secondary structureStrained conformationMatrix fibronectinNF-κB pathwayEssential roleFibrotic microenvironmentTumor metastasisPathwayConformational labilityStromal cellsTumor progressionCytokine releaseLung cancerInflammatory response