2021
Regulation of intercellular biomolecule transfer–driven tumor angiogenesis and responses to anticancer therapies
Lu Z, Ortiz A, Verginadis I, Peck A, Zahedi F, Cho C, Yu P, DeRita R, Zhang H, Kubanoff R, Sun Y, Yaspan A, Krespan E, Beiting D, Radaelli E, Ryeom S, Diehl J, Rui H, Koumenis C, Fuchs S. Regulation of intercellular biomolecule transfer–driven tumor angiogenesis and responses to anticancer therapies. Journal Of Clinical Investigation 2021, 131: e144225. PMID: 33998600, PMCID: PMC8121529, DOI: 10.1172/jci144225.Peer-Reviewed Original ResearchConceptsTumor growthEndothelial cellsMetastatic diseaseAnticancer therapyPoor disease outcomeColorectal cancerIntratumoral angiogenesisAngiostatic effectsDisease outcomeTherapeutic effectSide effectsOverall efficacyPharmacologic inhibitionTumor angiogenesisCH25HTherapyBenign cellsAngiogenesisDiseaseLow levelsCellsRegimensPatientsReserpineCancer
2020
Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis
Cho C, Mukherjee R, Peck AR, Sun Y, McBrearty N, Katlinski KV, Gui J, Govindaraju PK, Puré E, Rui H, Fuchs SY. Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis. Oncogene 2020, 39: 6129-6137. PMID: 32807917, PMCID: PMC7502515, DOI: 10.1038/s41388-020-01424-7.Peer-Reviewed Original ResearchConceptsCancer-associated fibroblastsFibroblast activation proteinType I interferon receptorTumor growthPancreatic ductal adenocarcinoma tumorsInterferon receptorKnockdown of Smad7Human colorectal cancerGrowth of tumorsSA miceColorectal cancerAdenocarcinoma tumorsSolid tumorsIFNAR1 downregulationGenetic ablationTumorsActivation proteinElevated levelsExtracellular matrixInverse correlationMiceStromagenesisIFNAR1IFNAR1 chainFAP levels